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Objective evaluation of the effect that an undernutrition state in anorexia nervosa causes to metabolism and cerebral function

Research Project

Project/Area Number 26460910
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionNational Center for Global Health and Medicine (2016)
Kyushu University (2014-2015)

Principal Investigator

Keisuke Kawai  国立研究開発法人国立国際医療研究センター, その他部局等, 心療内科医長 (80325521)

Co-Investigator(Kenkyū-buntansha) 田中 一成  長崎県立大学, 看護栄養学部, 教授 (20179740)
須藤 信行  九州大学, 医学研究院, 教授 (60304812)
久保 千春  九州大学, その他部局等, 学長 (80117100)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経性やせ症 / グレリン / 中鎖脂肪酸 / Default Mode Network / 極長鎖脂肪酸 / 心肺運動負荷試験 / Nutrition / Ghrelin / Anorexia nervosa / Nutrition / Ghrelin / Fatty Acids / Default Mode Network / Anorexia nervosa / Fatty acids
Outline of Final Research Achievements

The aim of this study is evaluation of the pathology from physical aspect in patients with anorexia nervosa (AN) and development of the effective therapy.
Results:(1) Medium-chain triglycerides(MCT 6g/day) admiration in AN for one month activate ghrelin and increased Neuropeptide Y(NPY), which has appetite improvement efects.These results suggest that MCT may be effective for the patients of malnutrition state.In additon, we proved that there was the abnormality for the metabolism of blood very long chain fatty acid(VLCF) in AN.(2) In the Default Mode Network study, we recognized the enhancement of the activity posterior cingulate cortex and prefrontal cortex in AN. (3) We evaluated the exercise durability ability using cardiopulumonary exercise training(CPX) in AN. The exercise durability ability of AN did not correlate with muscle mass and body weight.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (31 results)

All 2017 2016 2015 2014 Other

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (24 results) (of which Int'l Joint Research: 6 results,  Invited: 7 results) Remarks (1 results)

  • [Journal Article] 1.Ghrelin activation and neuropeptide Y elevation in response to medium chain triglyceride administration in anorexia nervosa patients2017

    • Author(s)
      Kawai K, Nakashima M, M Kojima M, Yamashita S, Takakura S, Shimizu M, Kubo C,Sudo N
    • Journal Title

      Clinical nutrition ESPEN

      Volume: 17 Pages: 100-104

    • DOI

      10.1016/j.clnesp.2016.10.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 摂食障害患者への心療内科病棟での看護師のかかわり2017

    • Author(s)
      松原栄子、河合啓介、上 久美子、黒木絵里、田崎朋子、山下 真、高倉 修、菊武恵子、貴船美保、須藤信行
    • Journal Title

      心身医

      Volume: 57 Pages: 368-375

    • NAID

      130005530272

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ストレス関連疾患を学ぶ―摂食障害2016

    • Author(s)
      河合 啓介
    • Journal Title

      Modern physician

      Volume: 36 Pages: 961-968

    • Related Report
      2016 Annual Research Report
  • [Journal Article] ストレスで悪化する内科疾患2016

    • Author(s)
      河合啓介
    • Journal Title

      Modern Physican

      Volume: 6 Pages: 0-0

    • Related Report
      2015 Research-status Report
  • [Journal Article] 栄養サポートチームの関わりかた2015

    • Author(s)
      河合啓介
    • Journal Title

      精神科臨床サービス

      Volume: 15 Pages: 454-458

    • Related Report
      2015 Research-status Report
  • [Journal Article] 1.神経性食欲不振症患者のRefeeding症候群に対する高リン含有栄養補助食品の利用の試み2014

    • Author(s)
      山下さきの、河合啓介、久保千春、須藤信行
    • Journal Title

      静脈経腸栄養学会

      Volume: 29 Pages: 1379-1383

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 中鎖脂肪酸トリグリセリド経口投与による生体内グレリン活性化研究ー神経性食欲不振症患者での検討2017

    • Author(s)
      河合 啓介
    • Organizer
      第32回日本静脈経腸栄養学会
    • Place of Presentation
      岡山
    • Year and Date
      2017-02-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] ダイエット再考2017

    • Author(s)
      河合 啓介
    • Organizer
      市民公開講座ー第18回日本消化器病学会
    • Place of Presentation
      宮城
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] シンポジウム「摂食障害」心療内科の立場から2017

    • Author(s)
      河合 啓介
    • Organizer
      第22回千葉総合病院精神科研究会
    • Place of Presentation
      千葉
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経性やせ症患者における心肺運動負荷試験を用いた運動耐容能についての検討2016

    • Author(s)
      山下 真 河合啓介 鈴山千恵 波夛伴和 髙倉修 須藤信行
    • Organizer
      第21回日本心療内科学会
    • Place of Presentation
      奈良
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] シンポジウムー働く女性と摂食障害2016

    • Author(s)
      河合啓介
    • Organizer
      第20回日本摂食障害学会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 1.Ghrelin activation and neuropeptide Y elevation in response to medium chain triglyceride administration for anorexia nervosa2016

    • Author(s)
      Keisuke Kawai, Sakino Yamashita, Shu Takakura, Chiharu Kubo, Nobuyuki Sudo
    • Organizer
      The 17th Asian Congress on Psychosomatic Medicine
    • Place of Presentation
      Fukuoka
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Symposium Eating disorders: Clinical Improvement and Changes in Default Mode Network with the Integrated Hospital Treatment for Anorexia Nervosa2016

    • Author(s)
      Motoharu Gondo, Keisuke Kawai, Yoshiya Moriguchi, Akio Hiwatashi, Shu Takakura, Kazufumi Yoshihara, Chihiro Morita, Makoto Yamashita, Sanami Eto, Nobuyuki Sudo
    • Organizer
      The 17th Asian Congress on Psychosomatic Medicine
    • Place of Presentation
      Fukuoka
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the exercise tolerability using cardiopulmonary exercise training in patients with anorexia nervosa2016

    • Author(s)
      Makoto Yamashita, Keisuke Kawai, Chie Suzuyama, Tomokazu Hata, Shu Takakura, Nobuyuki Sudo
    • Organizer
      The 17th Asian Congress on Psychosomatic Medicine
    • Place of Presentation
      Fukuoka
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alterations of default mode network in integrated hospital treatment of anorexia nervosa2016

    • Author(s)
      Motoharu Gondo, Keisuke Kawai, Yoshiya Moriguchi, Akio Hiwatashi, Shu Takakura, Kazufumi Yoshihara, Chihiro Morita, Makoto Yamashita, Sanami Eto, Nobuyuki Sudo
    • Organizer
      The 22nd Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Geneva
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シンポジウム 目に見えるストレス:ニューロイメージング心身医学の新展開 心身医学における安静時機能的MRI研究2016

    • Author(s)
      権藤元治、河合啓介、守口善也、樋渡昭雄、高倉 修、森田千尋、山下 真、吉原一文、江藤紗奈美、須藤信行
    • Organizer
      第57回日本心身医学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-06-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経性やせ症患者における心肺運動負荷試験を用いた運動耐容能の評価2016

    • Author(s)
      山下 真 河合啓介 鈴山千恵 波夛伴和 髙倉修 須藤信行
    • Organizer
      第57回日本心身医学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-06-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経性やせ症患者における心肺運動負荷試験を用いた運動耐容能の評価2016

    • Author(s)
      山下 真、河合啓介、須藤信行
    • Organizer
      第57回日本心身医学総会
    • Place of Presentation
      宮城
    • Year and Date
      2016-06-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 低栄養とメンタルヘルス2016

    • Author(s)
      河合啓介
    • Organizer
      日本心身会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2016-01-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 摂食障害の病態と治療ー最近のトピックス2016

    • Author(s)
      河合 啓介
    • Organizer
      九州大学QRプログラム研究事業
    • Place of Presentation
      福岡
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経性やせ症の安静時の脳機能2015

    • Author(s)
      権藤元治、河合啓介、須藤信行
    • Organizer
      第19回日本摂食障害学会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 神経性やせ症の治療前後における安静時脳機能の変化2015

    • Author(s)
      権藤元治、河合啓介、須藤信行
    • Organizer
      第20回日本心療内科学会
    • Place of Presentation
      盛岡
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] The outcome of treatment for anorexia nervosa inpatients who required urgent hospitalization2015

    • Author(s)
      K Kawai,S Yamashuita, N Sudo
    • Organizer
      23 World congress on Psychosomatic Medicine
    • Place of Presentation
      Glasgow
    • Year and Date
      2015-08-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 身体的要因で緊急入院した神経性やせ症の心理社会的特徴と予後に関する研究2015

    • Author(s)
      河合啓介 山下さきの 高倉 修 須藤信行
    • Organizer
      第56回日本心身医学会総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-06-26 – 2015-06-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 神経性食欲不振症のデフォルトモードネットワーク2015

    • Author(s)
      権藤元治, 河合啓介, 守口善也, 樋渡昭雄, 高倉 修, 須藤信行
    • Organizer
      第56回日本心身医学会総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-06-26 – 2015-06-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 神経性食欲不振症における血中脂肪酸濃度の検討2015

    • Author(s)
      清水 美希、河合啓介、高倉修、須藤信行
    • Organizer
      第56回日本心身医学会総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-06-26 – 2015-06-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 身体的要因で緊急入院した神経性やせ症の心理社会的特徴と予後に関する研究2015

    • Author(s)
      河合啓介、山下さきの、高倉 修、須藤信行
    • Organizer
      第56回日本心身医学総会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Default mode network in Anorexia nervosa2015

    • Author(s)
      M Gondo, K Kawai, N Sudo
    • Organizer
      21st Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Honolulu
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Default mode network in Anorexia nervosa2015

    • Author(s)
      M. Gondo , K Kawai, Y.Moriguchi, N.Sudo
    • Organizer
      Human Brain Mapping 2015
    • Place of Presentation
      Honolulu
    • Year and Date
      2015-06-14 – 2015-06-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 飢餓における脂肪酸代謝ー神経性食欲不振症における検討2014

    • Author(s)
      清水 美希、河合啓介、高倉修、須藤信行
    • Organizer
      第55回日本心身医学会総会
    • Place of Presentation
      幕張メッセ国際会議場(千葉県千葉市)
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Research-status Report
  • [Remarks] 九州大学研究者情報

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K000947/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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