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Effects of l-carnitine and branched-chain amino acids on energy metabolism, body composition and delayed-onset muscle soreness after exercise in normal healthy subjects

Research Project

Project/Area Number 26460917
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionWayo Women's University

Principal Investigator

Sakurai Yoichi  和洋女子大学, 生活科学系, 教授 (60170651)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
KeywordsL-カルニチン / 分岐鎖アミノ酸 / 骨格筋ストレスマーカー / 筋肉痛 / 疲労感 / 骨格筋 / 運動負荷 / 骨格筋酸化ストレス / L-carnitine / 身体組成 / カルニチン
Outline of Final Research Achievements

Young, untrained, healthy women were randomly assigned to two groups who received either 2 weeks of supplementation with L-carnitine (1000 mg/day) and a single dose of BCAAs plus 200 kcal energy (LCAR+BCAA group) or 200 kcal energy alone (control group) before 60 min of exercise. Energy substrate metabolism and body composition were examined before and after exercise. Delayed-onset muscle soreness was evaluated by using a visual analogue scale for 3 days after exercise. There were no significant differences in body composition before or after exercise between the two groups. Although serum free fatty acid levels 120 min after the oral ingestion of BCAAs were significantly lower in the LCAR+BCAA group than in the control group, there were no significant differences in serum free fatty acid levels immediately after and 60 min after exercise. DOMS after exercise was lower in the LCAR+BCAA group than in the control group.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] 健常者におけるカルニチン+BCAA投与後の運動負荷のエネルギー代謝・体組成に対する効果に関する基礎的検討2018

    • Author(s)
      櫻井洋一、長谷川由美、難波秀行、王堂哲
    • Journal Title

      日本静脈経腸栄養学会雑誌

      Volume: 33 Pages: 1-10

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of l-carnitine and branched-chain amino acids on energy metabolism, body composition and delayed-onset muscle soreness after exercise in normal healthy subjects2018

    • Author(s)
      Sakurai Y, Hasegawa Y, Kurosaka Y, Namba H, Odo S
    • Journal Title

      J Nutr Oncol

      Volume: In Press

    • NAID

      130007398680

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 健常者におけるカルニチン+BCAA投与後の運動負荷の体組成、骨格筋保護に対する効果2017

    • Author(s)
      長谷川由美、難波秀行、王堂哲、櫻井洋一
    • Journal Title

      栄養

      Volume: 1 Pages: 42-44

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Presentation] 運動負荷前後における長期的L-カルニチン単独、BCAA併用投与後の蛋白代謝、骨格筋保護に関する検討2018

    • Author(s)
      櫻井洋一, 黒坂由香、長谷川由美, 難波秀行, 王堂哲
    • Organizer
      第33回日本静脈経腸栄養学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of L-carnitine and branched-chain amino acids on energy metabolism, body composition before and after exercise in normal healthy subjects2017

    • Author(s)
      Yoichi Sakurai
    • Organizer
      2017 Chinese International Symposium of Nutritional Oncology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2017-04-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 運動負荷前後における長期的カルニチン単独、カルニチン+BCAA投与後のエネルギー基質代謝に関する検討2017

    • Author(s)
      長谷川由美、黒坂由香、難波秀行、王堂 哲
    • Organizer
      第32回 日本静脈経腸栄養学会学術集会
    • Place of Presentation
      岡山国際交流センター
    • Year and Date
      2017-02-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 運動負荷前後における長期的カルニチン単独、カルニチン+BCAA投与後の蛋白代謝、骨格筋保護に関する検討2017

    • Author(s)
      櫻井洋一、黒坂由香、長谷川由美、難波秀行、王堂 哲
    • Organizer
      第32回 日本静脈経腸栄養学会学術集会
    • Place of Presentation
      岡山国際交流センター
    • Year and Date
      2017-02-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Effects of L-carnitine and branched-chain amino acids on energy metabolism, body composition before and after exercise in normal healthy subjects2017

    • Author(s)
      Sakurai Y
    • Organizer
      2017 Chinese International Symposium of Nutritional Oncology and 5th National Conference on Cancer Nutrition and Supportive Care
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 運動負荷前後における長期的カルニチン単独、カルニチン+BCAA投与後のエネルギー基質代謝に関する検討2017

    • Author(s)
      長谷川由美, 黒坂由香, 難波秀行, 王堂哲, 櫻井洋一
    • Organizer
      第54回 日本外科代謝栄養学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フレイル防止に向けた運動負荷前後における長期的L-カルニチン単独、L-カルニチン+BCAA投与後の蛋白代謝、骨格筋保護に関する検討2017

    • Author(s)
      長谷川由美, 黒坂由香、難波秀行, 王堂哲, 櫻井洋一
    • Organizer
      第39回 日本臨床栄養学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 運動負荷前後における長期的カルニチン単独、カルニチン+BCAA投与後の蛋白代謝、骨格筋保護に関する検討2017

    • Author(s)
      櫻井洋一、黒坂由香、長谷川由美、難波秀行、王堂哲
    • Organizer
      第32回 日本静脈経腸栄養学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 運動負荷前後における長期的カルニチン単独、カルニチン+BCAA投与後のエネルギー基質代謝に関する検討2017

    • Author(s)
      長谷川由美、黒坂由香、難波秀行、王堂哲、櫻井洋一
    • Organizer
      第32回 日本静脈経腸栄養学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カルニチン+BCAA投与後の運動負荷前後におけるグルコース代謝とその制御因子に対する効果2016

    • Author(s)
      長谷川由美、難波秀行、王堂 哲、櫻井洋一
    • Organizer
      第38回 日本臨床栄養学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 健常者におけるカルニチン+BCAA投与後の運動負荷のエネルギー代謝, 体組成, 骨格筋保護に対する効果2016

    • Author(s)
      長谷川由美、難波秀行、櫻井洋一、王堂 哲
    • Organizer
      第53回 日本外科代謝栄養学会学術集会
    • Place of Presentation
      東京大学伊藤国際学術センター
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 健常者におけるカルニチン+BCAA投与後の運動負荷の体組成、骨格筋保護に対する効果2016

    • Author(s)
      長谷川由美、難波秀行、櫻井洋一、王堂 哲
    • Organizer
      第39回日本栄養アセスメント研究会学術集会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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