| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we found that kososan prevents social stress-induced depression-like behaviors by attenuating neuroinflammation in mice, although kososan does not have a recovery effect on the stress-triggered negative cognitive bias. Our preliminary data also suggest that kososan is effective for prevention of relapse in depression. These findings indicate that kososan has potential preventive effects on onset and recurrence of depression. And our verification that neuroinflammation is strongly involved in etiology of depression would be useful for drug discovery research in the future.
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