Efficacy of kososan on social stress - basic research using multi-behavioral battery-
| Project/Area Number |
26460918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kitasato University |
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Principal Investigator |
Ito Naoki 北里大学, 東洋医学総合研究所, 研究員 (00370164)
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| Research Collaborator |
HANAWA TOSHIHIKO 北里大学, 東洋医学総合研究所, 教授 (40164892)
OIKAWA TETSURO 北里大学, 東洋医学総合研究所, 部長 (10370165)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 香蘇散 / 社会的ストレス / 脳内炎症 / うつ / 再燃・再発 / 抑うつ / negative cognitive bias / マイクログリア |
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| Outline of Final Research Achievements |
In this study, we found that kososan prevents social stress-induced depression-like behaviors by attenuating neuroinflammation in mice, although kososan does not have a recovery effect on the stress-triggered negative cognitive bias. Our preliminary data also suggest that kososan is effective for prevention of relapse in depression. These findings indicate that kososan has potential preventive effects on onset and recurrence of depression. And our verification that neuroinflammation is strongly involved in etiology of depression would be useful for drug discovery research in the future.
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Report
(4 results)
Research Products
(5 results)
