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Host-mediated anti-influenza virus activity and action mechanism of a Kampo (traditional Japanese herbal) medicine "shakakusan"

Research Project

Project/Area Number 26460919
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionKitasato University

Principal Investigator

NAGAI Takayuki  北里大学, 大学院感染制御科学府, 准教授 (00172487)

Co-Investigator(Kenkyū-buntansha) 清原 寛章  北里大学, 大学院感染制御科学府, 教授 (70161601)
Co-Investigator(Renkei-kenkyūsha) ODAGUCHI Hiroshi  北里大学, 東洋医学総合研究所, 所長 (40214150)
Research Collaborator TAKAI Ryoichi  
OKAMURA Kazuma  
ITO Hironori  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords漢方薬 / 瀉白散 / 気道炎症 / インフルエンザ / 好中球 / ケモカイン / フラボノイド / 東洋医学 / ウイルス / 感染症 / 薬学 / 薬理学 / 肺炎 / ウィルス
Outline of Final Research Achievements

Hot-water extract of a Kampo (traditional Japanese herbal) medicine "shahakusan" or its constituents (liquiritigenin, morusin) was administered orally to the viral airway inflammation model mice prepared by intranasal inoculation of synthetic viral double-stranded RNA analog, Poly(I:C). The mRNA expression levels of inflammatory cytokines, neutrophil markers, neutrophil chemokines and their receptors in lungs increased by inoculation of Poly(I:C) were decreased by administration of shahakusan extract, and similar effects were observed in liquiritigenin and morusin. The mRNA expression levels of inflammatory cytokines and neutrophil chemokines increased in human bronchial epithelial cell line, BEAS-2B, by addition of Poly(I:C) were decreased by addition of shahakusan extract. Since similar actions were also observed in liquiritigenin and morusin, it was suggested that these constituents are at least a part of the active ingredients of shahakusan extract.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2015 2014 Other

All Presentation (6 results) (of which Invited: 1 results) Remarks (4 results)

  • [Presentation] 構成生薬の異なる補中益気湯煎剤の呼吸器粘膜免疫系調節作用の比較解析2017

    • Author(s)
      出原麻由、出野智史、松井英則、田中遥友、永井隆之、森崎浩、清原寛章
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学川内キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 漢方薬の効き目はどこまで解明されているか?ーインフルエンザと抑うつに対する基礎研究からー2017

    • Author(s)
      永井隆之
    • Organizer
      平成28年度北里大学薬学部生涯学習セミナー(後期)
    • Place of Presentation
      北里大学薬学部(東京都港区)
    • Year and Date
      2017-02-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 医療用補中益気湯エキス製剤の上気道粘膜免疫系賦活化作用成分の解析2015

    • Author(s)
      清原寛章、関谷路子、西本裕紀、施嘯睿、出原麻由、永井隆之、山田陽城
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 漢方方剤「小青竜湯」の抗炎症効果の作用機序の気道炎症モデルマウスを用いた検討2015

    • Author(s)
      高田果奈、永井隆之、高井亮一、清原寛章
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市中央区)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 瀉白散のウイルス性気道炎症に対する抑制作用の機序と活性成分の検討2014

    • Author(s)
      高井亮一、永井隆之、山田陽城、清原寛章
    • Organizer
      第31回和漢医薬学会学術大会
    • Place of Presentation
      幕張メッセ国際会議場(千葉県千葉市美浜区)
    • Year and Date
      2014-08-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 腸管パイエル板の免疫機能への和漢薬由来サポニン類の作用の解析2014

    • Author(s)
      小堀雄貴、永井隆之、白畑辰也、小林義典、清原寛章
    • Organizer
      第31回和漢医薬学会学術大会
    • Place of Presentation
      幕張メッセ国際会議場(千葉県千葉市美浜区)
    • Year and Date
      2014-08-31
    • Related Report
      2014 Research-status Report
  • [Remarks] 北里大学北里生命科学研究所・大学院感染制御科学府 研究室紹介

    • URL

      http://www.kitasato-u.ac.jp/lisci/life/chart/LSI-lab25.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 北里大学 北里生命科学研究所・感染制御科学府 和漢薬物学研究室のホームページ

    • URL

      http://www.lisci.kitasato-u.ac.jp:8080/bio_pharm/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 北里大学 北里生命科学研究所・感染制御科学府 和漢薬物学研究室のホームページ

    • URL

      http://www.lisci.kitasato-u.ac.jp:8080/bio_pharm/

    • Related Report
      2015 Research-status Report 2014 Research-status Report
  • [Remarks] 北里大学北里生命科学研究所・大学院感染制御科学府 研究室紹介

    • URL

      http://www.kitasato-u.ac.jp/lisci/life/chart/LSI-lab25.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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