| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Traditional Japanese herbal medicines (called kampo medicines in Japan, remedies composed of specified mixtures of crude drugs derived from plant, animal and mineral materials) have been applied for variety of diseases including mental diseases. Although some kampo medicines have been used traditionally for stress-related psychoneurogical diseases such as , the precise mechanism by which kampo medicines ameliorate these mental diseases remains unclear. Oral administration of some kampo medicines (kami-untanto, kihito, and its constituent polygalae radix)) ameliorated the stress-induced depression-like behavior of mice. We also found that oral administration of Polygalae Radix-extract increase the expression of GDNF mRNA and the number of dendritic spine.
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