Effect of kampo medicines on brain function
Project/Area Number |
26460925
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine(including psychosomatic medicine)
|
Research Institution | Setsunan University |
Principal Investigator |
YABE TAKESHI 摂南大学, 薬学部, 教授 (40239835)
|
Co-Investigator(Kenkyū-buntansha) |
荒木 良太 摂南大学, 薬学部, 助教 (90710682)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 漢方薬 / うつ様行動 / スパイン / GDNF / 精神疾患 / 加味温胆湯 / 神経新生 |
Outline of Final Research Achievements |
Traditional Japanese herbal medicines (called kampo medicines in Japan, remedies composed of specified mixtures of crude drugs derived from plant, animal and mineral materials) have been applied for variety of diseases including mental diseases. Although some kampo medicines have been used traditionally for stress-related psychoneurogical diseases such as , the precise mechanism by which kampo medicines ameliorate these mental diseases remains unclear. Oral administration of some kampo medicines (kami-untanto, kihito, and its constituent polygalae radix)) ameliorated the stress-induced depression-like behavior of mice. We also found that oral administration of Polygalae Radix-extract increase the expression of GDNF mRNA and the number of dendritic spine.
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Report
(4 results)
Research Products
(6 results)