| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The purpose of the present study is to elucidate the possible relationships among adipokines, endothelial function and membrane fluidity of red blood cells (RBCs) in hypertensive and normotensive subjects using an electron spin resonance (ESR) and spin-labeling method. The ESR study demonstrated that membrane fluidity was significantly decreased in hypertensive subjects compared with normotensive subjects. Furthermore, higher levels of plasma resistin were associated with decreased levels of plasma nitric oxide (NO) metabolites and reduced membrane fluidity of RBCs. On the other hand, bone mineral density was significantly lower in hypertensive elderly women than in normotensive elderly women. We propose that adipokine-mediated changes in membrane function and bone-metabolism might have a crucial role in the pathophysiology
of hypertension and the metabolic syndrome.
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