Defense system against viral infection by maoto through the enhancement of autophagy
| Project/Area Number |
26460929
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | インフルエンザ / 麻黄湯 / オートファジー / 炎症性サイトカイン / アポトーシス / エンドゾーム / インフルエンザウイルス / 漢方薬 / V-ATPase / ライソゾーム / インフラマゾーム |
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| Outline of Final Research Achievements |
This study was objected to clarify the anti-virus mechanism of maoto, the TraditionalJapanese herbal medicine, through autophagy. In vitro study of influenza virus infection showed that influenza caused the disfunction of autophagy and indued apoptosis. Maoto canncelled these disfunction of infected cells. Taken together, maoto strongly reduced the inflammatory cytokines, such as IL1 beta and Il-6 induced by infection through normalizing the autophagy. We also found that maoto inhibited the uncoating of influenza virus by inhibiting the acidification of endosomes, resulting in the blocking of influenza virus infection.
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Report
(5 results)
Research Products
(3 results)
