Cancer cachexia via cancer-nerve closstalk in pancreatic cancer
| Project/Area Number |
26460930
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Mitsunaga Shuichi 国立研究開発法人国立がん研究センター, 東病院, 医長 (20466197)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膵がん / 悪液質 / 神経浸潤 / 疼痛 / IL-6 / マウスモデル |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate the role of IL-6 N-inv in cachexia and pain via neural invasion (N-inv) using experimenral N-inv model of pancreatic cancer. N-inv model was made by the injection of Capan-1, human pancreatic cancer cell, into a left sciatic nerve of severe combined immunodeficiency mice.
N-inv mice showed an increase of human IL-6 level, tumoral IL-6, allodynia and a loss of body weight without appetite loss, which are compatible with an animal model of cancer cachexia. The shIL-6 clones to be originated from Capan-1 was used in N-inv model. A decrease of tumoral IL-6, the improvement of allodynya, and the suppression of N-inv distance were observed in the N-inv model using shIL-6 Capan-1, compared to the N-inv model using shRNA Capan-1. Tumoral IL-6 promotes N-inv and N-inv-related symptom as cachexia in N-inv model of pancreatic cancer.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] C-Reactive Protein Level Is an Indicator of the Aggressiveness of Advanced Pancreatic Cancer.2016
Author(s)
Mitsunaga S, Ikeda M, Shimizu S, Ohno I, Takahashi H, Okuyama H, Ueno H, Morizane C, Kondo S, Sakamoto Y, Okusaka T, Ochiai A.
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Journal Title
Pancreas
Volume: 45
Issue: 1
Pages: 110-116
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic impact of M2 macrophages at neural invasion in patients with invasive ductal carcinoma of the pancreas.2014
Author(s)
Sugimoto M, Mitsunaga S, Yoshikawa K, Kato Y, Gotohda N, Takahashi S, Konishi M, Ikeda M, Kojima M, Ochiai A, Kaneko H.
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Journal Title
Eur J Cancer
Volume: 50(11)
Issue: 11
Pages: 1900-8
DOI
Related Report
Peer Reviewed
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