| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The aim of this study is to elucidate the role of IL-6 N-inv in cachexia and pain via neural invasion (N-inv) using experimenral N-inv model of pancreatic cancer. N-inv model was made by the injection of Capan-1, human pancreatic cancer cell, into a left sciatic nerve of severe combined immunodeficiency mice.
N-inv mice showed an increase of human IL-6 level, tumoral IL-6, allodynia and a loss of body weight without appetite loss, which are compatible with an animal model of cancer cachexia. The shIL-6 clones to be originated from Capan-1 was used in N-inv model. A decrease of tumoral IL-6, the improvement of allodynya, and the suppression of N-inv distance were observed in the N-inv model using shIL-6 Capan-1, compared to the N-inv model using shRNA Capan-1. Tumoral IL-6 promotes N-inv and N-inv-related symptom as cachexia in N-inv model of pancreatic cancer.
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