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Mechanism of vascular endothelial autophagy in metabolic sydrome

Research Project

Project/Area Number 26460931
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Hayashi Shinichiro  国立研究開発法人国立循環器病研究センター, 病院, 医師 (20396740)

Co-Investigator(Kenkyū-buntansha) 里 直行  大阪大学, 医学系研究科, 寄附講座准教授 (70372612)
Co-Investigator(Renkei-kenkyūsha) YAMAMOTO Akitsugu  長浜バイオ大学, バイオサイエンス研究科, 教授 (30174775)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsオートファジー / 血管内皮細胞 / 生活習慣病 / 血管内皮
Outline of Final Research Achievements

The mechanism of endothelial dysfunction in metabolic syndrome, a forerunner of cardiovascular disease and atherosclerosis, still remains uncertain. In this study, we found several endothelial specific molecules whose regulation in the setting of metabolic syndrome could modulate endothelial autophagy. These findings indicate the possibilities that targeting endothelial autophagy would be a novel therapeutic option to prevent up-coming cardiovascular disease and atherosclerosis in patients with metabolic syndrome.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (36 results)

All 2018 2017 2016 2015 2014

All Journal Article (17 results) (of which Peer Reviewed: 16 results,  Open Access: 12 results,  Acknowledgement Compliant: 4 results) Presentation (18 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results) Book (1 results)

  • [Journal Article] Association between renal function and outcomes after percutaneous transluminal renal angioplasty in hypertensive patients with renal artery stenosis2018

    • Author(s)
      Iwashima Yoshio、Fukuda Tetsuya、Horio Takeshi、Hayashi Shin-ichiro、Kusunoki Hiroshi、Kishida Masatsugu、Nakamura Satoko、Kamide Kei、Kawano Yuhei、Yoshihara Fumiki
    • Journal Title

      Journal of Hypertension

      Volume: 36 Issue: 1 Pages: 126

    • DOI

      10.1097/hjh.0000000000001499

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Percutaneous Transluminal Renal Angioplasty on Office and Home Blood Pressure and Home Blood Pressure Variability in Hypertensive Patients with Renal Artery Stenosis2017

    • Author(s)
      Iwashima Y, Hayashi S 他
    • Journal Title

      HYPERTENSION

      Volume: 69 Issue: 1 Pages: 109

    • DOI

      10.1161/hypertensionaha.116.08124

    • URL

      https://pure.teikyo.jp/en/publications/36770e00-3802-41e9-958d-5f977f0c62f3

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effective uric acid-lowering treatment for hypertensive patients with hyperuricemia2017

    • Author(s)
      Ohta Yuko、Ishizuka Azusa、Arima Hisatomi、Hayashi Shinichiro、Iwashima Yoshio、Kishida Masatsugu、Yoshihara Fumiki、Nakamura Satoko、Kawano Yuhei
    • Journal Title

      Hypertension Research

      Volume: 40 Issue: 3 Pages: 259

    • DOI

      10.1038/hr.2016.139

    • URL

      https://pure.teikyo.jp/en/publications/7ff0fac9-e3e7-4341-925e-5297708cc42d

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of cigarette smoking on ambulatory blood pressure, heart rate, and heart rate variability in treated hypertensive patients2016

    • Author(s)
      Ohta Y, Hayashi S 他
    • Journal Title

      CLIN EXP HYPERTENS

      Volume: 38 Issue: 6 Pages: 510

    • DOI

      10.3109/10641963.2016.1148161

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salt intake and eating habits of school-aged children2016

    • Author(s)
      Ohta Y, Hayashi S 他
    • Journal Title

      HYPERTENS RES

      Volume: 39 Issue: 11 Pages: 812

    • DOI

      10.1038/hr.2016.73

    • URL

      https://pure.teikyo.jp/en/publications/10bbdaa4-213d-4f85-9161-86c6bf07d815

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence and risk factors for restenosis, and its impact on blood pressure control after percutaneous transluminal renal angioplasty in hypertensive patients with renal artery stenosis2016

    • Author(s)
      Iwashima Y, Hayashi S 他
    • Journal Title

      J HYPERTENS

      Volume: 34 Issue: 7 Pages: 1407

    • DOI

      10.1097/hjh.0000000000000928

    • URL

      https://pure.teikyo.jp/en/publications/9809df47-1cc4-42a1-b9b3-3fc006f09f76

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 高血圧とアルツハイマー病をつなぐ血管内皮のフェノタイプ変化. 医療と薬剤、生活習慣病予防の作用メカニズム2016

    • Author(s)
      林真一郎
    • Journal Title

      薬事日報 2016秋期 特集号

      Volume: 18

    • Related Report
      2016 Research-status Report
  • [Journal Article] Effects of daily walking on office, home and 24-h blood pressure in hypertensive patients2015

    • Author(s)
      Ohta Y, Hayashi S 他
    • Journal Title

      CLIN EXP HYPERTENS

      Volume: 37 Issue: 5 Pages: 433

    • DOI

      10.3109/10641963.2015.1013115

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Trends in the awareness of salt restriction and actual salt intake in hypertensive patients at a hypertension clinic and general clinic: A one-year follow-up study2015

    • Author(s)
      Ohat Y, Hayashi S 他
    • Journal Title

      CLIN EXP HYPERTENS

      Volume: 37 Issue: 6 Pages: 454

    • DOI

      10.3109/10641963.2015.1057835

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Related factors for worsening renal function following percutaneous transluminal renal angioplasty (PTRA) in patients with atherosclerotic renal artery stenosis2015

    • Author(s)
      Yoshihara F, Hayashi SI 他
    • Journal Title

      CLIN EXP HYPERTENS

      Volume: 37 Issue: 7 Pages: 526

    • DOI

      10.3109/10641963.2015.1013125

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of a selective aldosterone blocker and thiazide-type diuretic on blood pressure and organ damage in hypertensive patients2015

    • Author(s)
      Ohta Y, Hayashi S 他
    • Journal Title

      CLIN EXP HYPERTENS

      Volume: 37 Issue: 7 Pages: 569

    • DOI

      10.3109/10641963.2015.1026041

    • URL

      https://pure.teikyo.jp/en/publications/f4954ec7-4735-4fc2-8073-c83b1a34c7f4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Awareness of salt restriction and actual salt intake in hypertensive patients at a hypertension clinic and general clinic2015

    • Author(s)
      Ohta Y, Hayashi S 他
    • Journal Title

      Clin Exp Hypertens

      Volume: 37 Issue: 2 Pages: 172

    • DOI

      10.3109/10641963.2014.933965

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of daily waliking on office, home and 24-h blood pressure in hypertensive patients2015

    • Author(s)
      Ohta Y, Hayashi S 他
    • Journal Title

      Clin Exp Hypertens

      Volume: E-pub

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Related factors for worsening renal function following percutaneous transluminal renal angioplasty (PTRA) in patients with atherosclerotic renal artery stenosis2015

    • Author(s)
      Yoshihara F, Hayashi S 他
    • Journal Title

      Clin Exp Hypertens

      Volume: E-pub

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of tumor-producing VEGF-A in the recruitment of lymphatic endothelial progenitor cells from bone marrow.2014

    • Author(s)
      Tawada M, Hayashi S 他
    • Journal Title

      Oncol Rep

      Volume: 32 Issue: 6 Pages: 2359-2364

    • DOI

      10.3892/or.2014.3499

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison of efficacy of intensive versus mild pitavastatin therapy on lipid and inflammation biomarkers in hypertensive patients with dyslipidemia2014

    • Author(s)
      Iwashima/Jesmin S et al.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 2 Pages: e89057-e89057

    • DOI

      10.1371/journal.pone.0089057

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trend of office and home blood pressure control in treated hypertensive patients: Changes in antihypertensive medication and salt intake2014

    • Author(s)
      Ohta Y, Hayashi S(他6名)
    • Journal Title

      Clin Exp Hypertens

      Volume: 36 Issue: 2 Pages: 103

    • DOI

      10.3109/10641963.2014.892118

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳血管内皮のフェノタイプ変化とアルツハイマー病.2017

    • Author(s)
      林真一郎、里直行
    • Organizer
      第42回日本脳卒中学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Androgen receptor associated molecule, ARA70, modulates postnatal neovascularization.2017

    • Author(s)
      Hayashi S, ItoH 他
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hypertension interacts with Alzheimer’s disease via autophagy-related phenotypic changes of endothelial cells.2017

    • Author(s)
      Hayashi S.
    • Organizer
      Veterans Affairs Palo Alto Health Care System
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] アンドロゲンレセプター関連分子ARA70の血管内皮における働き2017

    • Author(s)
      林真一郎, 伊藤義晃 他
    • Organizer
      第40回日本高血圧学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 動脈硬化性の腎血管性高血圧患者における腎機能と経皮的腎血管形成術(PTRA)後の心血管・腎予後との関連2017

    • Author(s)
      岩嶋義雄、林真一郎 他
    • Organizer
      第40回日本高血圧学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血圧日内変動性と腎障害との関連:上腕血圧と中心血圧の同時測定による検討2017

    • Author(s)
      楠博、林真一郎 他
    • Organizer
      第40回日本高血圧学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 上腕血圧と中心血圧の日内変動性と腎障害との関連2017

    • Author(s)
      楠博、林真一郎 他
    • Organizer
      第60回日本腎臓学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Autopsy imaging, Ai, により腹部大動脈瘤ステントグラフト近位端の破裂が明らかになった透析の一症例.2016

    • Author(s)
      林真一郎 他
    • Organizer
      第61回日本透析医学会学術集会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 慢性期脳血管障害を有する入院患者の血圧管理の実際と薬物療法について2016

    • Author(s)
      中村敏子、林真一郎 他
    • Organizer
      第5回臨床高血圧フォーラム
    • Place of Presentation
      ステーションカンファレンス東京
    • Year and Date
      2016-05-14
    • Related Report
      2016 Research-status Report
  • [Presentation] NCOA4 transcriptional coactivator regulates vascular endothelial function and neovascularization2015

    • Author(s)
      Hayashi S
    • Organizer
      American Heart Association Scientific Sessions 2015
    • Place of Presentation
      Orland, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
  • [Presentation] Incidence and risk factor of restenosis, and its impact on blood pressure control after percutaneous transluminal renal renal angioplasty in patients with renovascular hypertension2015

    • Author(s)
      Iwashia Y, Hayashi S他
    • Organizer
      American Heart Association Scientific Sessions 2015
    • Place of Presentation
      Orland, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
  • [Presentation] Vascular endothelial growth factor-A and bone-marrow derived lymphatic endothelial precursor cells contribute to postnatal lymphangiogenesis in experimental models with human gastrointestinal adenocarcinoma2015

    • Author(s)
      Hayashi S
    • Organizer
      American Colleague of Gastroenterology
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 高血圧とアルツハイマー病をつなぐ血管内皮細胞のフェノタイプ変化2015

    • Author(s)
      林真一郎
    • Organizer
      第38回日本高血圧学会
    • Place of Presentation
      愛媛県県民文化会館
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 心臓移植患者における血管内皮機能と冠動脈プラークとの関連性2015

    • Author(s)
      渡邊琢也、林真一郎他
    • Organizer
      第63回日本心臓病学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Autophagy in vascular endothelium and diseases2014

    • Author(s)
      Hayashi S
    • Organizer
      Invitation Lecture in VA Palo Alto Hospital
    • Place of Presentation
      VA Palo Alto Hospital, CA, USA
    • Year and Date
      2014-11-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Autophagy in vascular endothelium and diseases2014

    • Author(s)
      Hayashi S
    • Organizer
      Invitaion Lecture in Stanford University
    • Place of Presentation
      Stanford University School of Medicine, CA, USA
    • Year and Date
      2014-11-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Reversal of impaired endothelial function in a patient with malignant hypertension.2014

    • Author(s)
      林真一郎
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] The related factors for the changes in renal function after percutaneous transluminal renal angioplasty(PTRA).2014

    • Author(s)
      Yoshihara F, Hayashi S 他
    • Organizer
      Congress of the European-Society-of- Cardiology
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Book] 血管診療テキスト:血圧測定2015

    • Author(s)
      林真一郎、河野雄平(分担執筆)
    • Total Pages
      378
    • Publisher
      メデイカ出版
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-12-27  

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