[13C]-naproxen breath test can predict the gastric mucosal injury induced by naproxen
| Project/Area Number |
26460935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
FURUTA TAKAHISA 浜松医科大学, 医学部附属病院, 准教授 (10303546)
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| Co-Investigator(Kenkyū-buntansha) |
大澤 恵 浜松医科大学, 医学部附属病院, 講師 (10397391)
松山 幸弘 浜松医科大学, 医学部, 教授 (20312316)
杉本 健 浜松医科大学, 医学部, 准教授 (20529507)
渡邉 裕司 浜松医科大学, 医学部, 教授 (50262803)
難波 宏樹 浜松医科大学, 医学部, 教授 (60198405)
小川 法良 浜松医科大学, 医学部附属病院, 講師 (80308618)
杉本 光繁 浜松医科大学, 医学部附属病院, 助教 (80397398)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 呼気試験 / ナプロキセン / NSAID / 13C / 呼気テスト / NSAIDS / Naproxen / 13CO2 / Prostaglandin / CYP2C9 |
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| Outline of Final Research Achievements |
W examined whether a [13C]-naproxen breath test ([13C]-NBT) could serve as the predictor of the gastric mucosal injuries induced by naproxen. We found that [13C]-NBT reflected metabolic profiles and the effect of naproxen on prostaglandin levels and could serve as a predictive marker of naproxen-induced gastric mucosal injury. We next prospectively tested the usefulness of [13C]-NBT for the tailored prophylaxis therapy for naproxen-induced gastric mucosal injuries. We found that [13C]-NBT was useful to select the subjects who were at the high risk of gastric mucosal injury on naproxen and needed the prophylaxis treatment with a PPI.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Influence of low-dose proton pump inhibitors administered concomitantly or separately on the anti-platelet function of clopidogrel.2017
Author(s)
Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Iwaizumi M, Hamaya Y, Osawa S, Sugimoto K, Umemura K.
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Journal Title
J Thromb Thrombolysis.
Volume: 43
Issue: 3
Pages: 333-342
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Digoxin Attenuates Murine Experimental Colitis by Downregulating Th17-related Cytokines.2017
Author(s)
Tani S, Takano R, Tamura S, Oishi S, Iwaizumi M, Hamaya Y, Takagaki K, Nagata T, Seto S, Horii T, Kosugi I, Iwashita T, Osawa S, Furuta T, Miyajima H, Sugimoto K.
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Journal Title
Inflamm Bowel Dis.
Volume: 23
Issue: 5
Pages: 728-738
DOI
Related Report
Peer Reviewed
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[Journal Article] Influence of Prostate Stem Cell Antigen Gene Polymorphisms on Susceptibility to Helicobacter pylori-associated Diseases: A Case-control Study2015
Author(s)
97.Ichikawa H, Sugimoto M, Uotani T, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Miyajima H, Yamaoka Y, Furuta T.
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Journal Title
Helicobacter
Volume: 20
Issue: 2
Pages: 106-113
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Dosing Schemes of Amoxicillin on Eradication Rates of Helicobacter pylori With Amoxicillin-Based Triple Therapy2014
Author(s)
Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K
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Journal Title
J Clin Pharmacol
Volume: 54
Issue: 3
Pages: 258-266
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Eradication of H. pylori infection in patients allergic to penicillin by the triple therapy with a PPI, metronidazole and sitafloxacin2014
Author(s)
Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K.
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Journal Title
Intern Med
Volume: 53
Pages: 571-575
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Sitafloxacin-based third-line rescue regimens for Helicobacter pylori infection in Japan2014
Author(s)
Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani TSahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K.
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Journal Title
J Gastroenterol Hepatol
Volume: 29
Issue: 3
Pages: 487-493
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Evaluation of the Accuracy of DK14-HP-001, a Novel H. pylori Stool Antigen Test, for the Diagnosis of H. pylori Infection2016
Author(s)
Furuta T, Sugimoto M, Sahara S, Ichikawa H, Kagami T, Uotani T, Yamade M, Hamaya Y, Iwaizumi M, Osawa S, Ken Sugimoto K
Organizer
DDW 2016
Place of Presentation
San Diego, CA, USA
Year and Date
2016-05-21
Related Report
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[Presentation] Our strategy ot eradication of H. pylori in patients with frequent failures of eradication.2015
Author(s)
Furuta T, Sugiimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Hamaya Y, Iwaizumi M, Osawa S, Sugimoto K
Organizer
UEG week 2015
Place of Presentation
Barcelona,Sapin
Year and Date
2015-10-24
Related Report
Int'l Joint Research
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[Presentation] Evaluation of the Accuracy of DB-13-04, a Novel Enzyme Immunoassay KIT, for the Detection of Anti-H. pylori IgG Antibody2015
Author(s)
Furuta T, Sugimoto M,Uotani T, Yamade M, Sahara S, Ichikawa H, Kagami T, Hamaya Y, Iwaizumi M, Osawa S, Sugimoto K
Organizer
DDW, AGA
Place of Presentation
Washington, D.C
Year and Date
2015-05-16
Related Report
Int'l Joint Research
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[Presentation] Personalized Therapy for H. pylori Infection Based on Automated SNP Analysis.2014
Author(s)
Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Iwaizumi M, Yamada T, Osawa S, Sugimoto K
Organizer
DDW 2014
Place of Presentation
Chicago
Year and Date
2014-05-02 – 2014-05-06
Related Report
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