Evaluation of reactivation of Notch signaling in the development and progression of adenocarcinoma in Barrett's esophagus

• Project/Area Number: 26460937
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Shimane University
• Principal Investigator: Ishimura Norihisa 島根大学, 医学部, 講師 (40346383)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: バレット食道 / シグナル伝達 / Notchシグナル / Cdx2 / 上皮間葉移行 / Notch

Outline of Final Research Achievements

The aim of this study was to investigate the relationship between Notch signaling and Cdx2 in the development of adenocarcinoma in Barrett’s esophagus. Inhibition of Notch signaling by Cdx2 has been reported to induce intestinal differentiation of esophageal columnar cells. While, Notch target genes, Hes-1, was significantly enhanced in Barrett’s adenocarcinoma. Likewise, enhanced expression of Hes-1 with decreased Cdx2 expression were found in Barrett’s adenocarcinoma cell lines. In addition, the expression of P27kip1 was related to those expressions. In Barrett’s adenocarcinoma, epithelial mesenchymal transition (EMT) related factors, such as Snail, were abundantly expressed, and those expressions were associated with Hes-1 expression. Collectively, we demonstrated that enhanced expression of Hes-1 with decreased Cdx2 expression played an important role in the development, progression, and invasion of adenocarcinoma in Barrett’s esophagus.

Research Products

• [Journal Article] Surveillance of patients with long-segment Barrett's esophagus: A multicenter prospective cohort study in Japan. (2017)
  • Author(s): Matsuhashi N, Sakai E, Ohata K, Ishimura N, Fujisaki J, Shimizu T, Iijima K, Koike T, Endo T, Kikuchi T, Inayoshi T, Amano Y, Furuta T, Haruma K, Kinoshita Y.
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 32 Issue: 2 Pages: 409-414
  • DOI: 10.1111/jgh.13491
  • Peer Reviewed
• [Journal Article] Mucosal breaks show same circumferential distribution in majority of patients with recurrent reflux esophagitis. (2017)
  • Author(s): Fukuda N, Ishimura N, Okada M, Izumi D, Mikami H, Okimoto E, Aimi M, Mishiro T, Oshima N, Ishihara S, Kinoshita Y
  • Journal Title: Endoscopy International Open Volume: 5 Issue: 03 Pages: E214-E221
  • DOI: 10.1055/s-0043-102401
  • Peer Reviewed / Open Access
• [Journal Article] Eosinophilic esophagitis versus proton pump inhibitor-responsive esophageal eosinophilia: Transcriptome analysis (2017)
  • Author(s): Shoda T, Matsuda A, Nomura I, Okada N, Orihara K, Mikami H, Ishimura N, Ishihara S, Matsumoto K, Kinoshita Y
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: - Issue: 6 Pages: 2010-2013
  • DOI: 10.1016/j.jaci.2016.11.028
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Specific locations of linear furrows in patients with esophageal eosinophilia (2017)
  • Author(s): Okimoto E, Ishimura N, Okada M, Izumi D, Mikami H, Aimi M, Tanimura T, Mishiro T, Oshima N, Ishikawa N, Ishihara S, Adachi K, Maruyama R, Kinoshita Y
  • Journal Title: Digestive Endoscopy Volume: 29 Issue: 1 Pages: 49-56
  • DOI: 10.1111/den.12706
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epidermal differentiation complex protein involucrin is down-regulated in eosinophilic esophagitis. (2017)
  • Author(s): Oshima N, Ishihara S, Fukuba N, Mishima Y, Kawashima K, Ishimura N, Ishikawa N, Maruyama R, Kinoshita Y
  • Journal Title: Esophagus Volume: 14 Issue: 2 Pages: 171-177
  • DOI: 10.1007/s10388-016-0568-y
  • NAID: 40021166323
  • Peer Reviewed
• [Journal Article] Diagnosis and treatment of eosinophilic esophagitis in Japan (2017)
  • Author(s): Kinoshita Y, Ishimura N, Mishiro T, Ishihara S, Adachi K
  • Journal Title: Esophagus Volume: 14 Issue: 1 Pages: 66-75
  • DOI: 10.1007/s10388-016-0550-8
  • NAID: 40021064445
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sustained Acid Suppression by Potassium-Competitive Acid Blocker (P-CAB) May Be An Attractive Treatment Candidate for Patients with Eosinophilic Esophagitis. (2016)
  • Author(s): Ishimura N, Ishihara S, Kinoshita Y
  • Journal Title: American Journal of Gastroenterology Volume: 111 Pages: 1203-4
  • Peer Reviewed
• [Journal Article] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: Comparisons of clinical, endoscopic, and histopathological findings in Japanese patients. (2016)
  • Author(s): Jiao D, Ishimura N, Maruyama R, Ishikawa N, Nagase M, Oshima N, Aimi M, Okimoto E, Mikami H, Izumi D, Okada M, Ishihara S, Kinoshita Y.
  • Journal Title: Journal of Gastroenterology Volume: 52 Issue: 2 Pages: 203-210
  • DOI: 10.1007/s00535-016-1213-1
  • Peer Reviewed / Open Access
• [Journal Article] Bile acids induce Delta-like 1 expression via Cdx2-dependent pathway in the development of Barrett's esophagus. (2016)
  • Author(s): Tamagawa Y, Ishimura N, Uno G, Aimi M, Oshima N, Yuki T, Sato S, Ishihara S, Kinoshita Y
  • Journal Title: Laboratory Investigation Volume: 96 Issue: 3 Pages: 325-337
  • DOI: 10.1038/labinvest.2015.137
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sustained acid suppression by potassium-competitive acid blocker (P-CAB) may be an attractive treatment candidate for patients with eosinophilic esophagitis. (2016)
  • Author(s): Ishimura N, Ishihara S, Kinoshita Y
  • Journal Title: American Journal of Gastroenterology Volume: 111 Issue: 8 Pages: 1203-1204
  • DOI: 10.1038/ajg.2016.167
  • Peer Reviewed / Open Access
• [Journal Article] Recent Progress in the Research of Eosinophilic Esophagitis and Gastroenteritis. (2016)
  • Author(s): Kinoshita Y, Ishimura N, Oshima N, Mikami H, Okimoto E, Jiao DJ, Ishihara S.
  • Journal Title: Digestion Volume: 93 Issue: 1 Pages: 7-12
  • DOI: 10.1159/000441668
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic accuracy of magnification endoscopy with acetic acid enhancement and narrow-band imaging in gastric mucosal neoplasms. (2016)
  • Author(s): Shibagaki K, Amano Y, Ishimura N, Taniguchi H, Fujita H, Adachi S, Kakehi E, Fujita R, Kobayashi K, Kinoshita Y
  • Journal Title: Endoscopy Volume: 48 Issue: 1 Pages: 16-25
  • DOI: 10.5056/jnm15116
  • Peer Reviewed
• [Journal Article] Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers. (2016)
  • Author(s): Mikami H, Ishimura N, Fukazawa K, Okada M, Izumi D, Shimura S, Okimoto E, Aimi M, Ishihara S, Kinoshita Y
  • Journal Title: Journal of Neurogastroenterology and Motility Volume: 22 Issue: 1 Pages: 112-117
  • DOI: 10.5056/jnm15130
  • Peer Reviewed
• [Journal Article] Barrett食道・腺癌の治療・予防をどう行うか (2016)
  • Author(s): 石村典久
  • Journal Title: 消化器の臨床 Volume: 19 Pages: 160-166
• [Journal Article] No increase in gastric acid secretion in healthy Japanese over the past two decades. (2015)
  • Author(s): Ishimura N, Owada Y, Aimi M, Oshima T, Kamada T, Inoue K, Mikami H, Takeuchi T, Miwa H, Higuchi K, Kinoshita Y
  • Journal Title: Journal of Gastroenterology Volume: 50 Issue: 8 Pages: 844-851
  • DOI: 10.1007/s00535-014-1027-y
  • Peer Reviewed
• [Journal Article] Magnification endoscopy with acetic acid enhancement and a narrow-band imaging system for pit pattern diagnosis of colorectal neoplasms. (2015)
  • Author(s): Shibagaki K, Amano Y, Ishimura N, Yuki T, Taniguchi H, Fujita H, Kobayashi K, Kinoshita Y
  • Journal Title: Journal of Clinical Gastroenterology Volume: 49 Issue: 4 Pages: 306-312
  • DOI: 10.1097/mcg.0000000000000148
  • Peer Reviewed
• [Journal Article] Prevalence of gastroesophageal reflux disease in children, adults, and elderly in the same community. (2015)
  • Author(s): Okimoto E, Ishimura N, Morito Y, Mikami H, Shimura S, Uno G, Tamagawa Y, Aimi M, Oshima N, Kawashima K, Kazumori H, Sato S, Ishihara S, Kinoshita Y
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 30 Issue: 7 Pages: 1140-1146
  • DOI: 10.1111/jgh.12899
  • Peer Reviewed
• [Journal Article] Systematic review: Eosinophilic esophagitis in Asian countries. (2015)
  • Author(s): Kinoshita Y, Ishimura N, Oshima N, Ishihara S
  • Journal Title: World Journal of Gastroenterology Volume: 21 Issue: 27 Pages: 8433-8440
  • DOI: 10.3748/wjg.v21.i27.8433
  • Peer Reviewed
• [Journal Article] Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteers. (2015)
  • Author(s): Ishimura N, Mori M, Mikami M, Shimura S, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y
  • Journal Title: BMC Gastroenterlogy Volume: 15 Issue: 1 Pages: 117-117
  • DOI: 10.1186/s12876-015-0346-7
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of gene expression profiles in eosinophilic esophagitis (EoE) between Japan and Western countries (2015)
  • Author(s): Shoda T, Morita H, Nomura I, Ishimura N, Ishihara S, Matsuda A, Matsumoto K, Kinoshita Y
  • Journal Title: Allergology International Volume: 64 Issue: 3 Pages: 260-265
  • DOI: 10.1016/j.alit.2015.03.002
  • NAID: 130005482445
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Circumferential distribution and location of Mallory-Weiss tears: recent trends. (2015)
  • Author(s): Okada M, Ishimura N, Shimura S, Mikami H, Okimoto E, Aimi M, Uno G, Oshima N, Yuki T, Ishihara S, Kinoshita Y
  • Journal Title: Endoscopy International Open Volume: 3 Issue: 05 Pages: E418-E424
  • DOI: 10.1055/s-0034-1392367
  • Peer Reviewed / Open Access
• [Journal Article] バレット食道の診断と治療、そして予防 (2015)
  • Author(s): 木下芳一、石村典久、石原俊治
  • Journal Title: GI FOREFRONT Volume: 11 Pages: 35-38
• [Journal Article] 食道、食道胃接合部のコンプライアンスを調べる：EndoFLIP検査 (2015)
  • Author(s): 三上博信、石村典久、木下芳一
  • Journal Title: G. I. Research Volume: 23 Pages: 9-15
• [Journal Article] PPI治療の課題と展望 (2015)
  • Author(s): 木下芳一、石村典久
  • Journal Title: 消化器の臨床 Volume: 18 Pages: 237-241
• [Journal Article] ボノプラザン登場の意義: 既存の酸分泌抑制薬が残した課題 (2015)
  • Author(s): 木下芳一、石村典久、石原俊治
  • Journal Title: Progress in Medicine Volume: 35 Pages: 1279-1283
• [Journal Article] 生活習慣病とGERD (2015)
  • Author(s): 木下芳一、相見正史、石村典久
  • Journal Title: Modern Physician Volume: 35 Pages: 1177-1182
• [Journal Article] Simplified classification of capillary pattern in Barrett esophagus using magnifying endoscopy with narrow band imaging: implications for malignant potential and interobserver agreement. (2015)
  • Author(s): Uno G, Ishimura N, Tada Y, Tamagawa Y, Yuki T, Matsushita T, Ishihara S, Amano Y, Maruyama R, Kinoshita Y
  • Journal Title: Medicine Volume: 94 Issue: 3 Pages: 521-527
  • DOI: 10.1097/md.0000000000000405
  • Peer Reviewed
• [Journal Article] Clinical features of eosinophilic esophagitis: Differences between Asian and Western populations. (2015)
  • Author(s): Ishimura N, Shimura S, Jiao D, Mikami H, Okimoto E, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y
  • Journal Title: J Gastroenterol Hepatol Volume: Suppl 1 Issue: S1 Pages: 1-7
  • DOI: 10.1111/jgh.12746
  • Peer Reviewed
• [Journal Article] 本邦におけるBarrett食道癌の疫学-現況と展望- (2015)
  • Author(s): 天野祐二、安積貴年、坪井優、本告成淳、石村典久
  • Journal Title: 日本消化器病学会雑誌 Volume: 112 Pages: 219-231
  • NAID: 130004776869
• [Journal Article] Pathophysiology of Barrett's esophagus-associated neoplasia: circumferential spatial predilection (2014)
  • Author(s): shimura N, Okada M, Mikami H, Okimoto E, Fukuda N, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y
  • Journal Title: Digestion Volume: 89 Issue: 4 Pages: 291-298
  • DOI: 10.1159/000365123
  • Peer Reviewed
• [Journal Article] Reliability of symptoms and endoscopic findings for diagnosis of esophageal eosinophilia in a Japanese population (2014)
  • Author(s): Shimura S, Ishimura N, Tanimura T, Yuki T, Miyake T, Kushiyama Y, Sato S, Fujishiro H, Ishihara S, Komatsu T, Kaneto E, Izumi A, Ishikawa N, Maruyama R, Kinoshita Y
  • Journal Title: Digestion Volume: 90 Issue: 1 Pages: 49-57
  • DOI: 10.1159/000365209
  • Peer Reviewed
• [Journal Article] Association between sleep disturbance and abdominal symptoms. (2014)
  • Author(s): Morito Y, Aimi M, Ishimura N, Shimura S, Mikami H, Okimoto E, Sato S, Ishihara S, Kushiyama Y, Katsube T, Adachi K, Kinoshita Y
  • Journal Title: Intern Med Volume: 53 Pages: 2179-2183
  • NAID: 130004694535
  • Peer Reviewed
• [Journal Article] Barrett食道腺癌の疫学―欧米との相違 (2014)
  • Author(s): 石村典久、木下芳一
  • Journal Title: 消化器内視鏡 Volume: 26 Pages: 486-493
• [Journal Article] 本邦におけるLSBE症例の臨床的特徴と長期経過観察 (2014)
  • Author(s): 石村典久、宇野吾一、結城崇史、天野祐二、木下芳一
  • Journal Title: 消化器内科 Volume: 59 Pages: 11-15
• [Journal Article] [PPI抵抗性GERDに使用される薬剤の特徴と使用上の注意] PPIの使用を工夫する (2014)
  • Author(s): 石村典久
  • Journal Title: 医学と薬学 Volume: 71 Pages: 553-561
• [Presentation] SOX2 and ΔNp63 Increase Squamous Cytokeratin Expression and Proliferation in Esophageal Squamous Cells, but Decrease Proliferation in Barrett’s Cells: A Potential Role for SOX2 and ΔNp63 Downregulation in Barrett’s Pathogenesis (2017)
  • Author(s): Tamagawa Y, Ding P, Ishimura N, Kinoshita Y, Zaidi AH, Jobe BA, Spechler SJ, Souza RF, Wang DH
  • Organizer: DDW 2017
  • Place of Presentation: Chicago, USA
  • Year and Date: 2017-05-06
  • Int'l Joint Research
• [Presentation] Barrett食道形成におけるBMPシグナルSMAD標準経路とp38MAPK非標準経路の役割に関する検討 (2017)
  • Author(s): 玉川祐司、石村典久、木下芳一
  • Organizer: 第103回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2017-04-20
• [Presentation] Diagnosis and treatment of eosinophilic esophagitis: current status in Japan (2017)
  • Author(s): Ishimura N
  • Organizer: 第103回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2017-04-20
  • Invited
• [Presentation] Circumferential distribution and clinical characteristics of esophageal cancer in lower esophagus - implications of histological subtype (2017)
  • Author(s): Okada M, Ishimura N, Mikami H, Okimoto E, Oshima N, Miyaoka Y, Fujishiro H, Ishihara S, Kinoshita Y
  • Organizer: 5th ANMA Congress
  • Place of Presentation: Osaka International Covention Center(Osaka, Japan)
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] Genome-wide transcriptome analysis shows no major difference between eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia (2017)
  • Author(s): Ishimura N, Shoda T, Matsuda A, Nomura I, Okada N, Orihara K, Mikami H, Okimoto E, Oshima N, Ishihara S, Matsumoto K, Kinoshita Y
  • Organizer: 5th ANMA Congress
  • Place of Presentation: Osaka International Covention Center（Osaka, Japan）
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] Esophageal triamcinolone acetonide-filling method for the prevention of esophageal stenosis after endoscopic submucosal dissection (2017)
  • Author(s): Shibagaki K, Ishimura N, Kinoshita Y
  • Organizer: The 10th IGICS
  • Place of Presentation: Nagoya Congress Center(Nagoya, Japan)
  • Year and Date: 2017-02-17
  • Int'l Joint Research
• [Presentation] 下部食道に発生する食道癌の周在性と臨床的特徴に関する検討 (2017)
  • Author(s): 岡田真由美，石村典久，三上博信，沖本英子，大嶋直樹，宮岡洋一, 藤代浩史，石原俊治，木下芳一
  • Organizer: 第13回日本消化管学会総会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋市）
  • Year and Date: 2017-02-17
• [Presentation] LSBEの長期経過に関する検討 (2016)
  • Author(s): 石村典久、岡田真由美、三上博信、石原俊治、木下芳一
  • Organizer: 第117回日本消化器内視鏡学会中国支部例会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Year and Date: 2016-11-12
• [Presentation] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients (2016)
  • Author(s): Jiao D, Ishimura N, Okada M, Mikami H, Izumi D, Okimoto E, Oshima N, Ishihara S, Kinosita Y
  • Organizer: APDW 2016
  • Place of Presentation: Kobe Convention Center(Kobe, Japan)
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] Epidermal differentiation complex protein involucrin is down-regulated in eosinophilic esophagitis. (2016)
  • Author(s): Oshima N, Ishihara S, Fukuba N, Mishima Y, Kawashima K, Ishimura N, Ishikawa N, Maruyama R, Kinoshita Y
  • Organizer: APDW 2016
  • Place of Presentation: Kobe Convention Center(Kobe, Japan)
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] Sustained acid suppression by potassium-competitive acid blocker (P-CAB) -possible treatment candidate for patients with eosinophilic esophagitis. (2016)
  • Author(s): Ishimura N, Okada M, Mikami H, Izumi D, Okimoto E, Mishiro T, Oshima N, Ishihara S, Kinoshita Y
  • Organizer: APDW 2016
  • Place of Presentation: Kobe Convention Center(Kobe, Japan)
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] LDN-193189, a BMP Type I Receptor Inhibitor, Reduces SMAD and p38MAPK Signaling and SOX9 Expression in Barrett’s Epithelial Cells: Potential Role for Canonical and Non-Canonical BMP4 Signaling in Barrett’s Pathogenesis (2016)
  • Author(s): Tamagawa Y, Ding P, Gichinga MW, Ishimura N, Kinoshita Y, Spechler SJ, Souza RF, Wang DH
  • Organizer: DDW 2016
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] Barrett食道内視鏡診断の正診率に関する検討～1cm未満のBarrett食道は正しく診断されているか？～ (2016)
  • Author(s): 石村 典久, 結城 崇史, 結城 美佳, 駒澤 慶憲, 串山 義則, 藤代 浩史, 木下 芳一
  • Organizer: 第91回日本消化器内視鏡学会総会
  • Place of Presentation: グランドプリンスホテル新高輪 国際館パミール（東京都港区）
  • Year and Date: 2016-05-12
• [Presentation] Endoscopic characteristics of 59 Japanese eosinophilic esophagitis patients. (2016)
  • Author(s): Okimoto E, Ishmura N, Izumi D, Mikami H, Aimi M, Tanimura T, Oshima N, Ishihara S, Adachi K, Kinoshita Y
  • Organizer: The 9th IGICS
  • Place of Presentation: Tokyo, Japan（京王プラザホテル）
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] 食道疾患の内視鏡診断と治療（Barrett食道・好酸球性食道炎を中心に） (2016)
  • Author(s): 石村典久
  • Organizer: 第25回日本消化器内視鏡学会中国支部セミナー
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2016-01-11
  • Invited
• [Presentation] Barrett食道腺癌の周在性と胃食道逆流の意義 (2016)
  • Author(s): 石村典久、岡田真由美、三上博信、石原俊治、木下芳一
  • Organizer: 第105回日本消化器病学会中国支部例会
  • Place of Presentation: 松江テルサ（松江市）
• [Presentation] 再発性逆流性食道炎の粘膜傷害の周在性についての検討 (2015)
  • Author(s): 福田直樹、石村典久、木下芳一
  • Organizer: JDDW 2015
  • Place of Presentation: グランドプリンスホテル新高輪（東京）
  • Year and Date: 2015-10-10
• [Presentation] 消化管運動機能改善薬の食道運動機能と食道胃接合部のコンプライアンスに及ぼす影響～EndoFLIPによる検討～ (2015)
  • Author(s): 三上博信、石村典久、木下芳一
  • Organizer: JDDW 2015
  • Place of Presentation: グランドプリンスホテル新高輪（東京）
  • Year and Date: 2015-10-09
• [Presentation] 好酸球性食道炎に認められる内視鏡所見についての検討 (2015)
  • Author(s): 沖本英子、泉大輔、三上博信、相見正史、谷村隆志、石村典久、足立経一、木下芳一
  • Organizer: 第69回日本食道学会学術集会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2015-07-03
• [Presentation] 好酸球性食道炎における内視鏡検査の意義-当院で経験した44例の解析 (2015)
  • Author(s): 石村典久、相見正史、木下芳一
  • Organizer: 第89回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2015-05-31
• [Presentation] 好酸球を可視化する～ラマン分光法を用いた好酸球性食道炎の診断～ (2015)
  • Author(s): 大嶋直樹、石村典久、木下芳一
  • Organizer: 第89回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2015-05-29
• [Presentation] Usefulness of CO2 enterography during double-balloon enteroscopy assisted endoscopic retrograde cholangiopancreatography. (2015)
  • Author(s): Moriyama I, Fukuba N, Sonoyama H, Tada Y, Oka A, Mishiro T, Oshima N, Tobita H, Yuki T, Kawashima K, Miyaka T, Ishimura N, Sato S, Ishihara S, Kinoshita Y
  • Organizer: DDW 2015
  • Place of Presentation: Washington, USA
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Presentation] BMP4 induces SOX9 and columnar cytokeratin expression in esophageal squamous cell and increases proliferation in Barrett’s cells through the p38MAPK pathway: potential roles for BMP4-p38MAPK signaling in Barrett’s pathogenesis and carcinogenesis. (2015)
  • Author(s): Tamagawa Y, Ding P, Zhang Q, Pham TH, Cheng E, Ishimura N, Kinoshita Y, Spechler SJ, Souza RF, Wang DH
  • Organizer: DDW 2015
  • Place of Presentation: Washington, USA
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] ⊿Np63 upregulates expression of squamous cytokeratins and increases proliferation in squamous cells, but decreases proliferation in Barrett’s cells: a potential role for downregulation of ⊿Np63 in Barrett’s pathogenesis. (2015)
  • Author(s): Tamagawa Y, Ding P, Zhang Q, Pham TH, Cheng E, Ishimura N, Kinoshita Y, Spechler SJ, Souza RF, Wang DH
  • Organizer: DDW 2015
  • Place of Presentation: Washington, USA
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] 日本人の胃酸分泌能は20年前よりも増えているのか？ (2015)
  • Author(s): 石村典久、大和田康子、相見正史、大島忠之、鎌田智有、井上和彦、三上博信、竹内利寿、三輪洋人、樋口和秀、木下芳一
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（仙台）
  • Year and Date: 2015-04-24
• [Presentation] 好酸球性消化管疾患の血中バイオマーカーの探索 (2015)
  • Author(s): 相見正史、石村典久、岡田真由美、泉大輔、三上博信、清村志乃、沖本英子、福田直樹、大嶋直樹、石原俊治、木下芳一
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（仙台）
  • Year and Date: 2015-04-24
• [Presentation] Clinical characteristics of 36 Japanese patients with eosinophilic esophagitis. (2015)
  • Author(s): Ishimura N, Izumi D, Mikami H, Shimura S, Aimi M, Uno G, Tanimura T, Oshima N, Furuta K, Fujishiro H, Izumi A, Ishihara S, Adachi K, Kinoshita Y
  • Organizer: The 8th IGICS
  • Place of Presentation: （Tokyo, Japan）京王プラザホテル
  • Year and Date: 2015-02-14
• [Presentation] マイクロアレイ解析による好酸球性食道炎の病態解明 (2014)
  • Author(s): 石村典久、石原俊治、木下芳一
  • Organizer: Japan Digestive Disease Week
  • Place of Presentation: （神戸市）神戸国際会議場
  • Year and Date: 2014-10-24
• [Presentation] 当院におけるBarrett腺癌症例の推移とその臨床的特徴 (2014)
  • Author(s): 宇野吾一、石村典久、結城崇史
  • Organizer: Japan Digestive Disease Week
  • Place of Presentation: （神戸市）神戸国際会議場
  • Year and Date: 2014-10-23
• [Presentation] Effects of metoclopramide on esophageal motor activity and esophagogastric junction compliance in healthy volunteers. (2014)
  • Author(s): Mikami H, Ishimura N, Fukazawa K, Aimi M, Uno G, Ishihara S, Kinoshita Y
  • Organizer: United European Gastroenterology Week
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-10-22
• [Presentation] Magnification endoscopy with acetic acid-enhancement and narrow-band imaging for predicting histologic characteristics of gastric mucosa neoplasms. (2014)
  • Author(s): Shibagaki K, Amano Y, Ishimura N, Taniguchi H, Fujita H, Kobayashi K, Kinoshita Y
  • Organizer: United European Gastroenterology Week
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-10-21
• [Presentation] No increase in gastric acid secretion in the Japanese over past two decades. (2014)
  • Author(s): Ishimura N, Owada Y, Aimi M, Oshima T, Kamada T, Inoue K, Mikami H, Takeuchi T, Miwa H, Higuchi K, Kinoshita Y
  • Organizer: United European Gastroenterology Week
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-10-21
• [Presentation] New simplified endoscopic classification of Barrett's esophagus using magnifying endoscopy with narrow band imaging: validation of objectivity and utility compared to histology. (2014)
  • Author(s): Uno G, Ishimura N, Tada Y, Tamagawa Y, Yuki T, Ishihara S, Amano Y, Kinoshita Y
  • Organizer: Digestive Disease Week
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-06
• [Presentation] Atonal homolog 1 (ATOH1) upregulates gastric- and intestinal-type protein expression in esophageal squamous cells, and increases proliferation in Barrett's cells: potential roles for ATOH1 in Barrett's pathogenesis and carcinogenesis. (2014)
  • Author(s): Tamagawa Y, Ishimura N, Tiwari A, Ding P, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y, Spechler SJ, Souza RF, Wang DH
  • Organizer: Digestive Disease Week
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-03