| Project/Area Number |
26460937
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | バレット食道 / シグナル伝達 / Notchシグナル / Cdx2 / 上皮間葉移行 / Notch |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the relationship between Notch signaling and Cdx2 in the development of adenocarcinoma in Barrett’s esophagus. Inhibition of Notch signaling by Cdx2 has been reported to induce intestinal differentiation of esophageal columnar cells. While, Notch target genes, Hes-1, was significantly enhanced in Barrett’s adenocarcinoma. Likewise, enhanced expression of Hes-1 with decreased Cdx2 expression were found in Barrett’s adenocarcinoma cell lines. In addition, the expression of P27kip1 was related to those expressions. In Barrett’s adenocarcinoma, epithelial mesenchymal transition (EMT) related factors, such as Snail, were abundantly expressed, and those expressions were associated with Hes-1 expression. Collectively, we demonstrated that enhanced expression of Hes-1 with decreased Cdx2 expression played an important role in the development, progression, and invasion of adenocarcinoma in Barrett’s esophagus.
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