Study of molecular basis of motilin and growth hormone secretagogue receptor

• Project/Area Number: 26460939
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: Matsuura Bunzo 愛媛大学, 医学系研究科, 寄附講座教授 (80284420)
• Research Collaborator: Kawamura Tomoe 愛媛大学, 大学院生 ; Takano Akiko 愛媛大学, 職員 ; Miller Lawrence J Mayo Clinic Arizona, Professor
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: モチリン受容体 / グレリン受容体 / 受容体活性化機構 / 受容体脱感作機構 / トランスジェニックマウス / BRET

Outline of Final Research Achievements

Motilin, erythromycin and ghrelin are important endogenous regulators of gastrointestinal motor function, mediated by the class A G protein-coupled motilin receptor (MLNR) and growth hormone secretagogue receptor (GHSR). We have clarified MLNR is induced desensitization by motilin, resulting from slow recycling to cell surface, compared to macrolides such as erythromycin. We also clarified in the MLNR-TG mice gastric empty time and small intestine transit time by MLNR agonists are shorter than WT mice.

Research Products

• [Int'l Joint Research] Mayo Clinic in Arizona(米国)
• [Journal Article] Differences in the risk of fatty liver for onset of impaired fasting glucose according to baseline plasma glucose levels (2017)
  • Author(s): Miyake T, Hirooka M, Yoshida O, Furukawa S, Kumagi T, Koizumi M, Yamamoto S, Kuroda T, Arimitsu E, Takeshita E, Abe M, Kitai K, Matsuura B, Hiasa Y
  • Journal Title: J Gastroenterol Volume: 52 Issue: 2 Pages: 237-244
  • DOI: 10.1007/s00535-016-1234-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Upregulated absorption of dietary palmitic acids with changes in intestinal transporters in non-alcoholic steatohepatitis (NASH) (2017)
  • Author(s): Utsunomiya H, Yamamoto Y, Takeshita E, Tokumoto Y, Tada F, Miyake T, Hirooka M, Abe M, Kumagi T, Matsuura B, Ikeda Y, Hiasa Y
  • Journal Title: J Gastroenterol Volume: 印刷中 Issue: 8 Pages: 940-954
  • DOI: 10.1007/s00535-016-1298-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Low alcohol consumption increases the risk of impaired glucose tolerance in patients with non-alcoholic fatty liver disease. (2016)
  • Author(s): Teruki Miyake
  • Journal Title: Journal of Gastroenterology Volume: 印刷中 Issue: 11 Pages: 1090-1100
  • DOI: 10.1007/s00535-016-1194-0
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Characterization of Liver Monocytic Myeloid-Derived Suppressor Cells and Their Role in a Murine Model of Non-Alcoholic Fatty Liver Disease (2016)
  • Author(s): Yao L, Abe M, Kawasaki K, Akbar SM, Matsuura B, Onji M, Hiasa Y.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0149948-e0149948
  • DOI: 10.1371/journal.pone.0149948
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Asian consensus on the relationship between obesity and gastrointestinal and liver diseases. (2016)
  • Author(s): Koh JC, Loo WM, Goh KL, Sugano K, Chan WK, Chiu WY, Choi MG, Gonlachanvit S, Lee WJ, Lee WJ, Lee YY, Lesmana LA, Li YM, Liu CJ, Matsuura B, Nakajima A, Ng EK, Sollano JD, Wong SK, Wong VW, Yang Y, Ho KY, Dan YY; GOASIA Workgroup
  • Journal Title: J Gastroenterol Hepatol Volume: 31 Issue: 8 Pages: 1-25
  • DOI: 10.1111/jgh.13385
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Usefulness of beta-cryptoxanthin for nonalcoholic fatty liver diseases (2016)
  • Author(s): Matsuura B, Miyake T, Yamamoto S, Furukawa S, Hiasa Y
  • Journal Title: J Food Nutr Disor Volume: 5 Issue: 3 Pages: 100196-100196
  • DOI: 10.4172/2324-9323.1000196
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diminished immune response to vaccinations in a murine model of obesity: Role of myeloid-derived suppressor cells. (2015)
  • Author(s): Chen S, Akbar SMF, Miyake T, Abe M, Al-Mahtab M, Furukawa S, Matsuura B, Hiasa Y, Onji M.
  • Journal Title: Obes Res Clin Pract Volume: 9 Issue: 1 Pages: 35-44
  • DOI: 10.1016/j.orcp.2013.12.006
  • Peer Reviewed / Open Access
• [Journal Article] Muscle atrophy as pre-sarcopenia in Japanese patients with chronic liver disease: computed tomography is useful for evaluation. (2015)
  • Author(s): Hiraoka A, Aibiki T, Okudaira T, Toshimori A, Kawamura T, Nakahara H, Suga Y, Azemoto N, Miyata H, Miyamoto Y, Ninomiya T, Hirooka M, Abe M, Matsuura B, Hiasa Y, Michitaka K
  • Journal Title: J Gastroenterol Volume: 50 Issue: 12 Pages: 1206-13
  • DOI: 10.1007/s00535-015-1068-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pancreatic congestion in liver cirrhosis correlates with impaired insulin secretion. (2014)
  • Author(s): Kuroda T, Hirooka M, Koizumi M, Ochi H, Hisano Y, Bando K, Matsuura B, Kumagi T, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: Epub Issue: 6 Pages: 583-9
  • DOI: 10.1007/s00535-014-1001-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 消化管ホルモン相互連関 (2014)
  • Author(s): 松浦文三，栗田ゆきえ，日浅陽一
  • Journal Title: 愛媛医学 Volume: 33 Pages: 176-179
  • Peer Reviewed / Open Access
• [Presentation] Desensitization of the human motilin receptor by motilin and motilides (2017)
  • Author(s): Matsuura B, Kawamura T, Yamamoto S, Senba H, Miyake T, Furukawa S, Abe M, Hiasa Y
  • Organizer: 5th Biennial Congress of the Asian Neurogastroenterology and Motility Association
  • Place of Presentation: 大阪，日本
  • Year and Date: 2017-03-23
• [Presentation] 創薬標的となる膜蛋白質受容体の発現と機能解析 (2017)
  • Author(s): 有光英治，前山一隆，丹下和洋，宇都宮大貴，八木専，山本安則，竹下英次，池田宜央，松浦文三，日浅陽一
  • Organizer: 第13回日本消化管学会総会学術集会
  • Place of Presentation: 名古屋，日本
  • Year and Date: 2017-02-17
• [Book] 内科学第11版 (2017)
  • Author(s): 松浦文三
  • Publisher: 朝倉書店
• [Remarks] 地域生活習慣病・内分泌学講座
  • URL: http://www.m.ehime-u.ac.jp/data/course/list_detail.php?id=201100000071