| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The objective of the present study was to investigate the mechanisms of myogenic tone regulation of lower esophageal sphincter to develop novel treatments for achalasia. The cytosolic Ca2+ concentration ([Ca2+]i) is a key role in maintenance of basal tone of LES. Na+/Ca2+ exchanger (NCX) contributed to controlling the [Ca2+]i more than L type Ca2+ channels. Furthermore, we have found that gasotransmitter hydrogen sulfate (H2S) plays an important role in regulation of NCX. Two H2S-generating enzymes, cystathione-g-synthase (CBS) and 3-mercaptopyruvate (3-MST), were responsible for endogenous H2S production in LES. A H2S/NCX pathway could be a novel therapeutic target for achalasia.
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