Roles and regulation of adipose tissue in the survival, growth, invasion and lipid droplet deposition of gastric cancer cells

• Project/Area Number: 26460941
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Saga University
• Principal Investigator: Shuji Toda 佐賀大学, 医学部, 教授 (80188755)
• Co-Investigator(Kenkyū-buntansha): 大谷 顕史 佐賀大学, 医学部, 客員研究員 (30363443) ; 坂田 資尚 佐賀大学, 医学部, 助教 (50404158)
• Co-Investigator(Renkei-kenkyūsha): SAKATA Yasuhis 佐賀大学, 医学部, 助教 (50404158)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 胃癌 / 脂肪組織 / 脂肪滴 / アポトーシス / 増殖 / 浸潤 / アディポカイン / 培養モデル / 胃癌細胞 / 脂肪滴沈着 / 生存 / 癌間質相互作用 / メタボリックシンドローム

Outline of Final Research Achievements

Adipose tissue is suggested to be associated with the pathogenesis of gastric cancer. The cancer cells generated in the mucosa infiltrate into submucosa, muscular layer and subsrosa, and they results in cancer peritonitis. On the other hand, adipose tissue abundantly exists in the submucosa, subserosa and intraabdominal space. In general, lipid derived from adipose tissue is suggested to actively influence cancer cell behavior. Thus, adipose tissue is expected to actively affect the behavior. However, adipose tissue-cancer interaction remains to be elucidated. Here, we studied the interaction and mechanisms.

Research Products

• [Journal Article] High-density collagen patch prevents stricture after endoscopic circumferential submucosal dissection of the esophagus: a porcine model (2017)
  • Author(s): Aoki S, Sakata Y, Shimoda R, Takezawa T, Oshikata-Miyazaki A, Kimura H, Yamamoto M, Iwakiri R, Fujimoto K, Toda S
  • Journal Title: Gastrointest Endosc Volume: 85 Issue: 5 Pages: 1076-1085
  • DOI: 10.1016/j.gie.2016.10.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Progress in cell culture systems for pathological research.2016 Oct; (2016)
  • Author(s): Aoki S, Takezawa T, Sugihara H, Toda S
  • Journal Title: Pathol Int. Volume: 66 Issue: 10 Pages: 554-562
  • DOI: 10.1111/pin.12443
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Differential effects of adipose tissue stromal cells on the apoptosis, growth and invasion of bladder urothelial carcinoma between the superficial and invasive types. (2016)
  • Author(s): Kawasaki-Nanri M, Aoki S, Uchihashi K, Yamamoto M, Udo K, Nishijima-Matsunobu A, Kakihara N, Noguchi M, Uozumi J, Toda S.
  • Journal Title: Int J Urol. Volume: 印刷中 Issue: 6 Pages: 510-19
  • DOI: 10.1111/iju.13086
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interaction between Esophageal Squamous Cell Carcinoma and Adipose Tissue in Vitro. (2016)
  • Author(s): Nakayama A, Aoki S, Uchihashi K, Nishijima-Matsunobu A, Yamamoto M, Kakihara N, Iwakiri R, Fujimoto K, Toda S
  • Journal Title: Am J Pathol. Volume: 印刷中 Issue: 5 Pages: 1180-94
  • DOI: 10.1016/j.ajpath.2016.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interaction between thyrocytes and adipose tissue in vitro. (2016)
  • Author(s): Yamamoto M, Uchihashi K, Aoki S, Koike E, Kakihara N, Toda S
  • Journal Title: Pathol Int Volume: 印刷中 Issue: 3 Pages: 148-157
  • DOI: 10.1111/pin.12387
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Book] 粥状動脈硬化症（メタボリックシンドロームを理解するための脂肪組織の基礎、血管周囲脂肪組織の特性と病態解析モデル） (2016)
  • Author(s): 柿原奈保子、内橋和芳、山本美保子、青木茂久、杉原甫、戸田修二
  • Total Pages: 354
  • Publisher: アトムス