Prediction of drug sensitivity to gastric cancer using BH3 profiling
| Project/Area Number |
26460943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KAWANO YUTAKA 札幌医科大学, 医学部, 助教 (80398320)
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| Co-Investigator(Kenkyū-buntansha) |
加藤 淳二 札幌医科大学, 医学部, 教授 (20244345)
佐藤 康史 徳島大学, 大学院医歯薬学研究部(医学系), 特任教授 (80343383)
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| Research Collaborator |
Letai Anthony ダナ・ファーバー癌研究所
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 抗癌剤感受性 / 胃癌 / BH3プロファイリング / 全生存期間 / 胃がん |
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| Outline of Final Research Achievements |
Drug sensitivity and BH3 profiling for seven gastric cancer cell lines were examined. BIM BH3 profiling results correlated with docetaxel sensitivity and also BAK protein expression. Patients with higher BAK protein expression in gastric cancer showed improved progression-free survival and overall survival.
BAK expression in gastric cancer is thus predictive of chemotherapeutic response to docetaxel and clinical prognosis in patients with docetaxel including chemotherapy.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer2016
Author(s)
Tomohiro Kubo, Yutaka Kawano, Nobuaki Himuro, Shintaro Sugita, Yasushi Sato, Kazuma Ishikawa, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Takayuki Nobuoka, Koichi Hirata, Tetsuji Takayama, Mitsuru Mori, Tadashi Hasegawa, Junji Kato
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Journal Title
Gastric Cancer
Volume: 19
Issue: 3
Pages: 827-838
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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