p53 family target ncRNAs and gastrointestinal tumorigenesis

• Project/Area Number: 26460944
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Sapporo Medical University
• Principal Investigator: Yasushi Sasaki 札幌医科大学, 医療人育成センター, 教授 (70322328)
• Co-Investigator(Renkei-kenkyūsha): MARUYAMA Reo 公益財団法人がん研究会, がん研究所, 研究員 (60607985)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 消化器癌 / p53 / p73 / p63 / ncRNA / 標的遺伝子 / miRNA / 非コードRNA / 消化器がん / p53ファミリー

Outline of Final Research Achievements

Recent studies revealed that p53 family proteins are important for the regulation of cell invasion and migration. Microarray analysis showed that breast cancer metastasis-suppressor 1- like (BRMS1L) is upregulated by p53 family proteins, specifically p53, TAp63γ, and TAp73β. We identified two responsive elements of p53 family proteins in the first intron and upstream of BRMS1L. These response elements are well conserved among mammals. Functional analysis showed that ectopic expression of BRMS1L inhibited cancer cell invasion and migration; knockdown of BRMS1L by siRNA induced the opposite effect. Importantly, clinical databases revealed that reduced BRMS1L expression correlated with poor prognosis in patients with breast and brain cancer. Altogether, these results strongly indicate that BRMS1L is one of the mediators downstream of the p53 pathway, and inhibits cancer cell invasion and migration, which are essential steps in cancer metastasis.

Research Products

• [Journal Article] Targeted sequencing reveals genetic variants associated with sensitivity of 79 human cancer xenografts to anticancer drugs. (2018)
  • Author(s): Udagawa C, Sasaki Y, Suemizu H, Ohnishi H, Tokino T, Zembutsu H
  • Journal Title: Experimental and Therapeutic Medicine Volume: 15 Pages: 1339-1359
  • DOI: 10.3892/etm.2017.5533
  • Peer Reviewed / Open Access
• [Journal Article] p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN. (2017)
  • Author(s): Tomoko Ohashi, Masashi Idogawa, Yasushi Sasaki, Takashi Tokino
  • Journal Title: Cancer Letters Volume: 390 Pages: 58-66
  • DOI: 10.1016/j.canlet.2016.12.034
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function. (2017)
  • Author(s): Masashi Idogawa, Tomoko Ohashi, Yasushi Sasaki, Hiroshi Nakase, Takashi Tokino
  • Journal Title: International Joural of Cancer Volume: 印刷中 Issue: 12 Pages: 2785-2791
  • DOI: 10.1002/ijc.30689
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation. (2017)
  • Author(s): Einaga N, Yoshida A, Noda H, Suemitsu M, Nakayama Y, Sakurada A, Kawaji Y, Yamaguchi H, Sasaski Y, Tokino T, Esumi M
  • Journal Title: PLoS One Volume: 12 Issue: 5 Pages: e0176280-e0176280
  • DOI: 10.1371/journal.pone.0176280
  • Peer Reviewed / Open Access
• [Journal Article] Fledglings in p53 signaling network. (2017)
  • Author(s): Tokino T, Idogawa M, Sasaki Y
  • Journal Title: Oncotarget Volume: 8 Issue: 34 Pages: 55768-55769
  • DOI: 10.18632/oncotarget.19229
  • Peer Reviewed / Open Access
• [Journal Article] Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing. (2017)
  • Author(s): Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima H, Ohashi T, Idogawa M, Ogi K, Hiratsuka H, Tokino T, Sasaki Y
  • Journal Title: Oncotarget Volume: 8 Issue: 35 Pages: 59113-59122
  • DOI: 10.18632/oncotarget.19262
  • Peer Reviewed / Open Access
• [Journal Article] Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53. (2017)
  • Author(s): Koyama R, Tamura M, Nakagaki T, Ohashi T, Idogawa M, Suzuki H, Tokino T, Sasaki Y
  • Journal Title: Cancer Science Volume: 108 Issue: 12 Pages: 2413-2421
  • DOI: 10.1111/cas.13420
  • Peer Reviewed / Open Access
• [Journal Article] The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy. (2017)
  • Author(s): Matsunaga Y, Adachi Y, Sasaki Y, Koide H, Motoya M, Nosho K, Takagi H, Yamamoto H, Sasaki S, Tokino T, Carbone DP, Imai K, Shinomura Y
  • Journal Title: Molecular Carcinogenesis Volume: VOL. 56 Issue: 2 Pages: 515-526
  • DOI: 10.1002/mc.22513
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells. (2016)
  • Author(s): Kai M, Niinuma T, Kitajima H, Yamamoto E, Harada T, Aoki H, Maruyama R, Toyota M, Sasaki Y, Sugai T, Tokino T, Nakase H, Suzuki H.
  • Journal Title: PLoS One Volume: 11 Issue: 12 Pages: e0168281-e0168281
  • DOI: 10.1371/journal.pone.0168281
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target. (2016)
  • Author(s): Sasaki Y, Tamura M, Takeda K, Ogi K, Nakagaki T, Koyama R, Idogawa M, Hiratsuka H, Tokino T
  • Journal Title: Oncotarget Volume: VOL. 7 Issue: 38 Pages: 61426-61437
  • DOI: 10.18632/oncotarget.11366
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress (2016)
  • Author(s): Hiroshi Saijo, Yoshihiko Hirohashi, et al.
  • Journal Title: Oncotarget Volume: 2;7(31) Issue: 31 Pages: 50043-50056
  • DOI: 10.18632/oncotarget.10571
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing (2016)
  • Author(s): Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T.
  • Journal Title: WORLD JOURNAL OF GASTROENTEROLOGY Volume: 22 Issue: 7 Pages: 2284-2293
  • DOI: 10.3748/wjg.v22.i7.2284
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Systemic Prophylactic Antibiotics for the Modified Introducer Method for Percutaneous Endoscopic Gastrostomy: A Prospective, Randomized, Double-Blind Study (2016)
  • Author(s): Adachi Y, Akino K, Mita H, Kikuchi T, Yamashita K, Sasaki Y, Arimura Y, Endo T
  • Journal Title: J Clin Gastroenterol Volume: 50 Issue: 9 Pages: 727-732
  • DOI: 10.1097/mcg.0000000000000470
  • Peer Reviewed / Open Access
• [Journal Article] Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing. (2015)
  • Author(s): Ikeda H, Ishiguro K, Igarashi T, Aoki Y, Hayashi T, Ishida T, Sasaki Y, Tokino T, Shinomura Y.
  • Journal Title: Onco Targets Ther. Volume: 8 Pages: 2805-2815
  • DOI: 10.2147/ott.s86515
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors (2015)
  • Author(s): Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
  • Journal Title: Oncotarget Volume: 6 Issue: 30 Pages: 29975-90
  • DOI: 10.18632/oncotarget.5034
  • NAID: 130005161526
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CRKL oncogene is downregulated by p53 through miR-200s (2015)
  • Author(s): Tamura M, Sasaki Y, Kobashi K, Takeda K, Nakagaki T, Idogawa M, Tokino T.
  • Journal Title: CANCER SCIENCE Volume: 106 Issue: 8 Pages: 1033-1040
  • DOI: 10.1111/cas.12713
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells (2014)
  • Author(s): Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T.
  • Journal Title: Oncotarget Volume: 15 Pages: 7540-8
  • Peer Reviewed
• [Journal Article] Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites (2014)
  • Author(s): Idogawa M, Ohashi T, Sasaki Y, Maruyama R, Kashima L, Suzuki H, Tokino T
  • Journal Title: Hum Mol Genet Volume: 23 Issue: 11 Pages: 2847-2857
  • DOI: 10.1093/hmg/ddt673
  • Peer Reviewed / Open Access
• [Journal Article] Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness (2014)
  • Author(s): Tamura M, Sasaki Y, Koyama R, Takeda K, Idogawa M, Tokino T
  • Journal Title: Oncogene Volume: (in press) Issue: 40 Pages: 4837-4846
  • DOI: 10.1038/onc.2013.427
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions (2014)
  • Author(s): Ito M, Mitsuhashi K, Igarashi H, Nosho K, Yamamoto H
  • Journal Title: Int J Cancer Volume: (Epub ahead of print) Issue: 11 Pages: 2507-2515
  • DOI: 10.1002/ijc.28920
  • Peer Reviewed / Open Access
• [Presentation] Targeted exome sequences of cancer-related genes in human cancers using amplicon sequencing (2017)
  • Author(s): Sasaki Y, Nakagaki T, Tamura M, Fukushima F, Ikeda H, Koyama R, Idogawa M, Tokino T
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2017
  • Int'l Joint Research
• [Presentation] Mutation detection by target sequence analyses using tissue-specific panels in esophageal squamous cell carcinoma. (2017)
  • Author(s): Iwaya T, Endo F, Kume K, Sasaki Y, Tokino T, Nishizuka S
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2017
  • Int'l Joint Research
• [Presentation] Exome sequencing of cancer-related genes to identify genetic markers for sensitivity to cytotoxic anticancer drugs (2017)
  • Author(s): Idogawa C, Sasaki Y, Suemizu H, Ohnishi Y, Ohnishi H, Tokino T, Zembutsu H
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2017
  • Int'l Joint Research
• [Presentation] Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing (2017)
  • Author(s): Sasaki Y, Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima F, Idogawa M, Ogi K, Hiratsuka H, Tokino T
  • Organizer: The 12th International Workshop on Advanced Genomics
  • Int'l Joint Research
• [Presentation] p53標的遺伝子BRMS1Lの同定と機能解析 (2017)
  • Author(s): 佐々木泰史，小山良太，田村みゆき，中垣貴文，大箸智子，井戸川雅史，時野隆至
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] LIMA1は新規p53標的遺伝子であり癌細胞浸潤を抑制する (2016)
  • Author(s): 大箸智子，井戸川雅史，佐々木泰史，時野隆至
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-02
• [Presentation] 半導体シークエンサーを用いたがん関連遺伝子のターゲットシークエンス解析 (2016)
  • Author(s): 佐々木泰史，中垣貴文，田村みゆき，福島久代，池田博，小山良太，大箸智子，井戸川雅史，仲瀬裕志，時野隆至
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-01
• [Presentation] Identification of somatic mutations and copy number variations in multiple myeloma using next generation sequencin (2016)
  • Author(s): Fukushima H, Sasaki Y, Tamura M, Ikeda H, Ishiguro K, Tokino T, Sakurai A
  • Organizer: The 66th Annual Meeting of The American Society of Human Genetics
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2016-10-19
  • Int'l Joint Research
• [Presentation] がん領域におけるクリニカルシークエンスの現状と未来 (2016)
  • Author(s): 佐々木泰史
  • Organizer: 第１回 道南臨床分子病態研究会
  • Place of Presentation: 函館国際ホテル（北海道函館市）
  • Year and Date: 2016-10-11
  • Invited
• [Presentation] 癌におけるp53および長鎖非コードRNA（lncRNA）による転写ネットワーク解析 (2016)
  • Author(s): 井戸川雅史，大箸智子，佐々木泰史，時野隆至
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-08
• [Presentation] 新規p53標的遺伝子LIMA1は癌細胞浸潤を抑制し低発現が予後不良と相関する (2016)
  • Author(s): 大箸智子，井戸川雅史，田村みゆき，中垣貴文，小山良太，佐々木泰史， 時野隆至
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-08
• [Presentation] p53ファミリー遺伝子の標的としてのBRMS1L (breast cancer metastasis suppressor 1 like, BRMS1-like)の同定と機能解析 (2016)
  • Author(s): 小山良太，佐々木泰史，田村みゆき，中垣貴文，大箸智子，井戸川雅史，時野隆至
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-07
• [Presentation] 口腔扁平上皮癌におけるがん関連50遺伝子の変異解析 (2016)
  • Author(s): 佐々木泰史，中垣貴文，田村みゆき，小山良太，福島久代，大箸智子，井戸川雅史，荻和弘，平塚博義，時野隆至
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] Targeted exome sequencing of cancer-related genes for somatic mutations and copy number variations in human cancer using the semiconductor sequencer (2016)
  • Author(s): Sasaki Y, Koyama R, Nakagaki T, Tamura M, Fukushima H, Ikeda H, Koyama R, Ohashi T, Idogawa M, Tokino T.
  • Organizer: 43th ISOBM Annual Congress of International Society of Oncology and BioMarkers (ISOBM)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] p53 downregulates CRKL oncogene through miR-200 (2016)
  • Author(s): Tokino T, Tamura M, Idogawa M, Sasaki Y
  • Organizer: American Association of Cancer Research (AACR) annual meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-04-19
  • Int'l Joint Research
• [Presentation] Targeted sequencing of 409 cancer-related genes for somatic mutations and copy number variations in human cancer using the semiconductor sequencers (2016)
  • Author(s): Sasaki Y, Koyama R, Nakagaki T, Tamura M, Idogawa M, Tokino T
  • Organizer: American Association of Cancer Research (AACR) annual meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-04-19
  • Int'l Joint Research
• [Presentation] Semiconductor-based next-generation sequencing analysis of 409 cancer-related genes for mutations and copy-number variations in oral squamous cell carcinoma (2016)
  • Author(s): Nakagaki T, Sasaki Y, Idogawa M, Koyama R, Kobashi K, Tamura M, Ohashi T, Ogi K, Hiratsuka H, Tokino. T.
  • Organizer: American Association of Cancer Research (AACR) annual meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-04-19
  • Int'l Joint Research
• [Presentation] Targeted semiconductor sequencing of 409 cancer-related genes for somatic mutations and copy number variations in multiple myeloma (2016)
  • Author(s): Ikeda H, Sasaki Y, Ishiguro K, Ishida T, Aoki Y, Tokino T
  • Organizer: American Association of Cancer Research (AACR) annual meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-04-19
  • Int'l Joint Research
• [Presentation] The identification of p53 target genes and noncoding RNAs through the combined analysis of RNA-seq and ChIP-seq data (2016)
  • Author(s): Idogawa M, Ohashi T, Sasaki Y, Tokino T
  • Organizer: American Association of Cancer Research (AACR) annual meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-04-18
  • Int'l Joint Research
• [Presentation] Targeted semiconductor sequencing of 409 cancer-related genes for somatic mutations and copy number variations in multiple myeloma (2016)
  • Author(s): Fukushima H, Ikeda H, Ishiguro K, Igarashi T, Aoki Y, Hayashi T, Ishida T, Sasaki Y, Sakurai A, Tokino T
  • Organizer: The 13th Annual Meeting of the International Congress of Human Genetics
  • Place of Presentation: 国立京都国際会館（京都市左京区）
  • Year and Date: 2016-04-05
  • Int'l Joint Research
• [Presentation] 次世代シーケンサーを用いたがん関連409遺伝子のターゲットシーケンス解析 (2015)
  • Author(s): 佐々木泰史，小山良太，中垣貴文，田村みゆき，大箸智子，井戸川雅史，時野隆至
  • Organizer: 第38回日本分子生物学会年会（BMB2015）
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] 癌細胞におけるゲノムワイドRNAiスクリーニングを用いたp53誘導性アポトーシス抵抗性を解除するshRNAの探索 (2015)
  • Author(s): 梅田璃子，井戸川雅史，大箸智子，佐々木泰史，時野隆至
  • Organizer: 第38回日本分子生物学会年会（BMB2015）
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] 半導体シーケンサーを用いたがん関連遺伝子のターゲットシーケンス解析 (2015)
  • Author(s): 佐々木泰史，中垣貴文，田村みゆき，竹田康佑，大箸智子，井戸川雅史，時野隆至
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] RNA-seqとChIP-seqの複合解析による非コードRNAを含むp53標的遺伝子の同定 (2015)
  • Author(s): 井戸川雅史，大箸智子，佐々木泰史，時野隆至
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] CRKLはmiR-200ファミリーを介してp53により発現抑制される (2015)
  • Author(s): 田村みゆき，佐々木泰史，竹田康佑，中垣貴文，大箸智子，井戸川雅史，時野隆至
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] p53による癌細胞浸潤の抑制には新規標的遺伝子LIMA1の発現誘導が必要である (2015)
  • Author(s): 大箸智子，井戸川雅史，田村みゆき，竹田康佑，中垣貴文，佐々木泰史，時野隆至
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness. (2015)
  • Author(s): Sasaki Y, Tamura M, Koyama R, Takeda K, Idogawa M, Tokino T
  • Organizer: The 34th Sapporo International Cancer Symposium, 2015
  • Place of Presentation: Sapporo ロイトン札幌（北海道札幌市）
  • Year and Date: 2015-06-25
  • Int'l Joint Research
• [Presentation] The CRKL oncogene is downregulated by p53 through miR-200s (2015)
  • Author(s): Tamura M, Sasaki Y, Kobashi K, Takeda K, Nakagaki T, Idogawa M, Tokino T
  • Organizer: The 34th Sapporo International Cancer Symposium, 2015
  • Place of Presentation: Sapporo ロイトン札幌（北海道札幌市）
  • Year and Date: 2015-06-25
  • Int'l Joint Research
• [Presentation] p53 downregulates CRKL proto-oncogene protein through miR-200 family (2015)
  • Author(s): Sasaki Y, Tamura M, Kobashi K, Takeda K, Nakagaki T, Idogawa M, Tokino T.
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2015
  • Place of Presentation: Pennsylvania, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Comprehensive genomic analyses of oral squamous cell carcinoma tissues by semiconductor-based next-generation sequencing (2015)
  • Author(s): Nakagaki T, Sasaki Y, Kobashi K, Takeda K, Tamura M, Ohashi T, Ogi K, Idogawa M, Hiratsuka H, Tokino. T
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2015
  • Place of Presentation: Pennsylvania, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 family target (2015)
  • Author(s): Takeda K, Sasaki Y, Nakagaki T, Tamura M, Ohashi T, Ogi K, Idogawa M, Hiratsuka H, Tokino T
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2015
  • Place of Presentation: Pennsylvania, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Molecular diagnostics of drug resistant multiple myeloma cases using targeted next generation sequencing (2015)
  • Author(s): Ikeda H, Sasaki Y, Igarashi T, Aoki Y, Hayashi T, Ishida T, Tokino T, Sinomura Y.
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2015
  • Place of Presentation: Pennsylvania, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] The effect of forced expression of k-ras mutation on gastrointestinal cancer cells and IGF-IR targeting therapy (2015)
  • Author(s): Adachi Y, Matsunaga Y, Sasaki Y, Nosho K, Yamamoto Y, Arimura Y, Endo T, Kato Y, Tokino T, Carbone DP, Shinomura Y
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2015
  • Place of Presentation: Pennsylvania, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Ion PGMシーケンサーを用いたがん関連遺伝子の網羅的変異解析 (2014)
  • Author(s): 小橋 建太, 佐々木 泰史, 中垣 貴文, 竹田 康佑, 田村 みゆき, 大箸 智子, 井戸川 雅史, 時野 隆至
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-26
• [Presentation] 半導体シーケンサーを用いたがん関連遺伝子の網羅的解析 (2014)
  • Author(s): 佐々木泰史、中垣貴文、田村みゆき、竹田康佑、井戸川雅史、大箸智子、鈴木拓、篠村恭久、時野隆至
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] p53 のmiR-200 ファミリーを介したCRKL の発現抑制 (2014)
  • Author(s): 田村みゆき、佐々木泰史、竹田康佑、中垣貴文、大箸智子、井戸川雅史、時野隆至
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] Ion PGMシーケンサーを用いたがん関連遺伝子の網羅的変異解析 (2014)
  • Author(s): 佐々木泰史， 中垣貴文， 田村みゆき， 小橋健太， 竹田康佑， 井戸川雅史 ，鈴木拓 ， 篠村恭久， 時野隆至
  • Organizer: 第94回北海道医学大会 腫瘍系分科会
  • Place of Presentation: 札幌
  • Year and Date: 2014-09-13
• [Presentation] p53 negatively regulates the hepatoma growth factor HDGF (2014)
  • Author(s): Sasaki Y, Negishi H, Idogawa M, Koyama R, Kusano M, Suzuki H, Fujita M, Maruyama R, Toyota M, Saito T, Tokino T
  • Organizer: 第79回日本インターフェロン・ サイトカイン学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2014-06-19
• [Presentation] Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53 binding sites (2014)
  • Author(s): Idogawa M, Ohashi T, Sasaki Y, Tokio T
  • Organizer: The 16th International p53 Workshop
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2014-06-14
• [Presentation] p53 family network and tumor suppression (2014)
  • Author(s): Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
  • Organizer: The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
  • Place of Presentation: Zhangjiajie, China
  • Year and Date: 2014-06-12
  • Invited
• [Presentation] Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness (2014)
  • Author(s): Tokino T, Tamura M, Idogawa M, Sasaki Y
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-06
• [Remarks] 札幌医科大学医学部附属フロンティア医学研究所 ゲノム医科学部門
  • URL: http://web.sapmed.ac.jp/canmol/index.html
• [Remarks] 札幌医科大学医学部・付属フロンティア医学研究所・ゲノム医科学部門
  • URL: http://web.sapmed.ac.jp/canmol/index.html