Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Outline of Final Research Achievements |
The analyses in long-term three-dimensional method for primary mouse glandular stomach culture have shown that the gastric mesenchymal myofibroblast (GMF) is important for the differentiation and proliferation of gastric epithelial cell. Growth arrest specific 1(GAS1)expression is higher in GMF, and Homeobox C8(HoxC8)、Notch 1、SRY-box containing gene 10(Sox10) are higher in intestinal mesenchymal myofibroblast, suggesting that these factors play the key roles in the gastric and intestinal differentiation by epithelial-mesenchymal interactions. We consider that the ectopic MUC5AC expression in the intestinal epithelial cells may be a predictive factor of recurrence or remission in the cases of Crohn's disease and intestinal Behçet's disease.
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