| Project/Area Number |
26460947
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KATAOKA Hiromi 名古屋市立大学, 大学院医学研究科, 准教授 (40381785)
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| Co-Investigator(Kenkyū-buntansha) |
矢野 重信 奈良先端科学技術大学院大学, 物質創成科学研究科, 客員教授 (60011186)
鈴木 周五 名古屋市立大学, 大学院医学研究科, 研究員 (60363933)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Testuya 獨協医科大学, 医学部, 教授 (90348029)
TANAKA Mamoru 名古屋市立大学, 大学院医学研究科, 臨床研究医 (80617861)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 光線力学的療法 / 光線力学的診断法 / PDT / PDD / 光感受性物質 / LED / LASER / 光線力学療法 / マンノース受容体 / 腫瘍会合性マクロファージ / M2様マクロファージ |
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| Outline of Final Research Achievements |
Photodynamic therapy (PDT) using mannose-conjugated chlorin (M-chlorin) designed to target tumor-associated macrophages (TAMs) in cancer stroma (which express high level of mannose receptors) showed very strong cytotoxicity against not only TAMs but also cancer cells. We also synthesized oligosaccharide-conjugated chlorin (O-chlorin) with improved water-solubility. O-chlorin showed very excellent photodynamic diagnosis effects as well as PDT effects.
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