Development of a novel photodynamic therapy with sugar-conjugated chlorin targeting tumor-associated macrophages in cancer stroma.
Project/Area Number |
26460947
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Nagoya City University |
Principal Investigator |
KATAOKA Hiromi 名古屋市立大学, 大学院医学研究科, 准教授 (40381785)
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Co-Investigator(Kenkyū-buntansha) |
矢野 重信 奈良先端科学技術大学院大学, 物質創成科学研究科, 客員教授 (60011186)
鈴木 周五 名古屋市立大学, 大学院医学研究科, 研究員 (60363933)
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Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Testuya 獨協医科大学, 医学部, 教授 (90348029)
TANAKA Mamoru 名古屋市立大学, 大学院医学研究科, 臨床研究医 (80617861)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 光線力学的療法 / 光線力学的診断法 / PDT / PDD / 光感受性物質 / LED / LASER / 光線力学療法 / マンノース受容体 / 腫瘍会合性マクロファージ / M2様マクロファージ |
Outline of Final Research Achievements |
Photodynamic therapy (PDT) using mannose-conjugated chlorin (M-chlorin) designed to target tumor-associated macrophages (TAMs) in cancer stroma (which express high level of mannose receptors) showed very strong cytotoxicity against not only TAMs but also cancer cells. We also synthesized oligosaccharide-conjugated chlorin (O-chlorin) with improved water-solubility. O-chlorin showed very excellent photodynamic diagnosis effects as well as PDT effects.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Maltotriose conjugated to a chlorin derivative enhances the antitumor effects of photodynamic therapy in peritoneal dissemination of pancreatic cancer.2017
Author(s)
Kato A, Kataoka H, Yano S, Hayashi K, Hayashi N, Tanaka M, Naitoh I, Ban T, Miyabe K, Kondo H, Yoshida M, Fujita Y, Hori Y, Natsume M, Murakami T, Narumi A, Nomoto A, Naiki-Ito A, Takahashi S, Joh T
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Journal Title
Mol Cnacer Ther
Volume: 印刷中
Issue: 6
Pages: 1124-1132
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Anti-cancer effects of a new aminosugar-conjugated platinum complex agent against cisplatin-resistant gastric cancer.2016
Author(s)
Hayashi N, Kataoka H, Yano S, Kikuchi JI, Tanaka M, Nishie H, Kinoshita Y, Hatano M, Nomoto A, Ogawa A, Inoue M, Mizoshita T, Shimura T, Mori Y, Kubota E, Tanida S, Joh T.
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Journal Title
Anticancer Res
Volume: 36(11)
Pages: 6005-6009
Related Report
Peer Reviewed
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[Journal Article] Immunogenic cell death due to a new photodynamic therapy with glycoconjugated chlorin2016
Author(s)
Tanaka M, Kataoka H, Yano S, Sawada T, Akashi H, Inoue M, Suzuki S, Inagaki Y, Hayashi N, Nishie H, Shimura T, Mizoshita T, Mori Y, Kubota E, Tanida S, Takahashi S, Joh T.
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Journal Title
Oncotarget
Volume: 26; 7(30)
Issue: 30
Pages: 47242-47251
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A phase II prospective study of the trastuzumab combined with 5-weekly S-1 and CDDP therapy for HER2-positive advanced gastric cancer.2016
Author(s)
Kataoka H, Mori Y, Shimura T, Nishie H, Natsume M, Mochizuki H, Hirata Y, Sobue S, Mizushima T, Sano H, Mizuno Y, Nakamura M, Hirano A, Tsuchida K, Adachi K, Seno K, Kitagawa M, Kawai T, Joh T.
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Journal Title
Cancer Chemother Pharmacol.
Volume: 77(5)
Issue: 5
Pages: 957-62
DOI
Related Report
Peer Reviewed
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[Journal Article] Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility.2016
Author(s)
Atsushi Narumi, Takahiro Tsuji, Kosuke Shinohara, Hiromi Yamazaki, Moriya Kikuchi, Seigou Kawaguchi, Timoya Mae, Atsushi Ikeda, Yuichi Sakai, Hiromi Kataoka, Masahiro Inoue, Akihiro Nomoto, Jun-ichi Kikuchi, Shigenobu Yano.
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Journal Title
Org. Biomol. Chem
Volume: 14(14)
Issue: 14
Pages: 3608-13
DOI
Related Report
Peer Reviewed
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[Journal Article] Autonomic nervous responses in colorectal polypectomy: Randomized control trial comparing air and carbon dioxide insufflation.2016
Author(s)
Murakami K, Kataoka H, Hayano J, Fukuta H, Mori Y, Nishiwaki H, Mizoshita T, Tanaka M, Okamoto Y, Shimura T, Hirata Y, Mizushima T, Ebi M, Joh T.
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Journal Title
Dig Endosc.
Volume: 28
Issue: 2
Pages: 203-209
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel photodynamic therapy targeting cancer cells and tumor-associated macrophages.2015
Author(s)
N. Hayashi, H. Kataoka, S. Yano, M. Tanaka, K. Moriwaki, H. Akashi, S. Suzuki, Y. Mori, E. Kubota, S. Tanida, S. Takahashi, T. Joh.
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Journal Title
Mol Cancer Ther.
Volume: 14(2)
Pages: 452-460
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 糖鎖連結クロリンを用いた新規光線力学的がん診断法.2014
Author(s)
Mamoru Tanaka, Hiromi Kataoka, Shingo Hamano, Masahide Ebi, Tsutomu Mizoshita, Yoshinori Mori, Eiji Kubota, Shigenobu Yano and Takashi Joh.
Organizer
第73回日本癌学会学術総会
Place of Presentation
パシフィコ横浜 (神奈川県,横浜市)
Year and Date
2014-09-25 – 2014-09-27
Related Report
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