Analysis of Lgr5-positive cells in the intestinal metaplasia
Project/Area Number |
26460948
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Jichi Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
武藤 弘行 自治医科大学, 医学部, 教授 (50322392)
坂本 博次 自治医科大学, 医学部, 講師 (50536175)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | Lgr5 |
Outline of Final Research Achievements |
Intestinal metaplasia is precancerous lesion of the stomach. We investigated the expression of Lgr5 in intestinal metaplasia and gastric carcinoma. By crossbreeding Cdx2-transgenic mouse and Lgr5-EGFP-ires-CreERT2 mouse, Lgr5-expression in intestinal metaplasia and gastric carcinoma was identified. By crossbreeding Lgr5-EGFP-ires-CreERT2-mouse, ROSA26-Loxp-stop-Loxp-LacZ-mouse, Cdx2-transgenic mouse, it was suggested that Lgr5 is induced by Cdx2.
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Report
(4 results)
Research Products
(2 results)