| Project/Area Number |
26460953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大島 忠之 兵庫医科大学, 医学部, 准教授 (00381814)
渡 二郎 兵庫医科大学, 医学部, 教授 (10311531)
三輪 洋人 兵庫医科大学, 医学部, 教授 (80190833)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 遺伝子 / 再生医学 / 臨床 / 感染症 / 免疫学 |
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| Outline of Final Research Achievements |
Reg protein plays a protective roles against NSAIDs-induced gastrointestinal injury by promoting cell proliferation and anti-apoptosis in the epithelium and endothelium in the gastrointestinal tissues. In addition, Reg protein stimulation increases the expression of tight junction proteins in the epithelial cells by activating Sp1, Akt and ERK signaling, resulting in the enhancement of intercellular barrier function. Gut microbiota plays a pivotal role in the expression of Reg protein, and the induced Reg protein may be involved in the cytokine production and differentiation in immune cells.
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