Development of new treatment with trafficking modulation of colitogenic memory lymphocytes.

• Project/Area Number: 26460963
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: FUJII TOSHIMITSU 東京医科歯科大学, 医学部附属病院, 助教 (30547451)
• Co-Investigator(Kenkyū-buntansha): 永石 宇司 東京医科歯科大学, 医学部附属病院, 助教 (60447464) ; 渡辺 守 (渡邉 守) 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 下部消化管学 / 炎症性腸疾患 / 新規治療 / 腸管免疫 / リンパ球動態制御 / 下部消化管学（小腸、大腸）

Outline of Final Research Achievements

Fingolimod is a sphingosine-1-phosphate receptor modulator, which inhibits T cell egress from lymph nodes, thereby prevents pathogenic T cells from migrating towards disease sites. In inflammatory bowel diseases (IBD), it is thought that colitogenic memory T cells are reactivated in regional lymphoid organs, and return to inflammatory tissues. We demonstrated that fingolimod prevents the development of colitis induced by the adoptive transfer of naive T cells (naive T colitis) and colitogenic effector-memory T cells (memory T colitis) into SCID mice. Next, we demonstrated that fingolimod decreased T cells in peripheral blood, but conversely increased in bone marrow in the mice lacking lymph nodes and spleen. Notably, fingolimod prevented the development of memory T colitis without lymph nodes and spleen. Collectively, fingolimod may offer an additional role to direct trafficking of T cells in bone marrow, resulting in the prevention of memory T cell-mediated diseases including IBD.

Research Products

• [Journal Article] Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy. (2017)
  • Author(s): Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Fujioka T, Araki A, Watanabe M.
  • Journal Title: J Gastroenterol. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Endoscopic features and genetic background of inflammatory bowel disease complicated with Takayasu arteritis. (2017)
  • Author(s): Akiyama S, Fujii T, Matsuoka K, Yusuke E, Negi M, Takenaka K, Nagahori M, Ohtsuka K, Isobe M, Watanabe M.
  • Journal Title: J Gastroenterol Hepatol. Volume: 32 Issue: 5 Pages: 1011-1017
  • DOI: 10.1111/jgh.13640
  • Peer Reviewed
• [Journal Article] Epithelial Nuclear Factor-kB Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis. " (2016)
  • Author(s): Nagaishi T,Watabe T,Jose N, Tokai A, Fujii T, Matsuoka K, Nagahori M, Ohtsuka K
  • Journal Title: Digestion Volume: 93 Issue: 1 Pages: 40-46
  • DOI: 10.1159/000441670
  • Peer Reviewed / Open Access
• [Journal Article] Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn's disease. (2016)
  • Author(s): Ohtsuka K, Takenaka K, Kitazume Y, Fujii T, Matsuoka K, Kimura M, Nagaishi T, Watanabe M.
  • Journal Title: Intest Res. Volume: 14 Issue: 2 Pages: 120-126
  • DOI: 10.5217/ir.2016.14.2.120
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. (2016)
  • Author(s): Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Memoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
  • Journal Title: Sci. Rep. Volume: 6 Issue: 1 Pages: 36780-36780
  • DOI: 10.1038/srep36780
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tacrolimus for the Treatment of Ulcerative Colitis. (2015)
  • Author(s): Matsuoka K, Saito E, Fujii T, Takenaka K, Kimura M, Nagahori M, Ohtsuka K, Watanabe M.
  • Journal Title: Intest Res. Volume: 13 Issue: 3 Pages: 219-226
  • DOI: 10.5217/ir.2015.13.3.219
  • Peer Reviewed
• [Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. (2015)
  • Author(s): Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
  • Journal Title: Autophagy Volume: 11 Issue: 7 Pages: 1052-1062
  • DOI: 10.1080/15548627.2015.1055439
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] クローン病画像モダリティとしてのMRI (2015)
  • Author(s): 藤井俊光、渡辺 守
  • Journal Title: 日本消化器病学会雑誌 Volume: 112 Pages: 15-22
  • NAID: 130005084744
  • Peer Reviewed
• [Journal Article] Correlation of the endoscopic and magnetic resonance scoring systems in the deep small intestine in Crohn’s disease. (2015)
  • Author(s): Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Fujioka T, Matsuoka K, Naganuma M, Watanabe M
  • Journal Title: Inflamm Bowel Dis. Volume: 未
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] New Technology MRIによる腸管評価法 (2015)
  • Author(s): 藤井俊光
  • Journal Title: Medical Science Digest Volume: 41 Pages: 199-200
• [Journal Article] Advancing magnetic resonance imaging in Crohn's disease. (2014)
  • Author(s): Fujii T, Naganuma M, Kitazume Y, Saito E, Nagahori M, Ohtsuka K, Watanabe M.
  • Journal Title: Digestion Volume: 89 Issue: 1 Pages: 24-30
  • DOI: 10.1159/000356210
  • NAID: 130005084744
  • Peer Reviewed
• [Journal Article] Comparison of Magnetic Resonance and Balloon Enteroscopic Examination of Deep Small Intestine in Patients with Crohn's Disease. (2014)
  • Author(s): Takenaka K, Ohtsuka K,Watanabe M et al
  • Journal Title: Gastroenterology Volume: [Epub ahead of print] Issue: 2 Pages: 334-342
  • DOI: 10.1053/j.gastro.2014.04.008
  • Peer Reviewed
• [Journal Article] Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis. (2014)
  • Author(s): Saito E, Nagahori M, Fujii T, Otsuka K, Watanabe M
  • Journal Title: Digestion Volume: 89 Issue: 1 Pages: 55-60
  • DOI: 10.1159/000356221
  • Peer Reviewed
• [Journal Article] Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. (2014)
  • Author(s): Suzuki M, Nagaishi T, Yamazaki M, Onizawa M, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M.
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e88369-e88369
  • DOI: 10.1371/journal.pone.0088369
  • Peer Reviewed / Open Access
• [Journal Article] RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. (2014)
  • Author(s): Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
  • Journal Title: Biochem Biophys Res Commun Volume: 456(1) Issue: 1 Pages: 298-304
  • DOI: 10.1016/j.bbrc.2014.11.075
  • Peer Reviewed / Open Access
• [Journal Article] 炎症性腸疾患の画像診断 modality IV. MRI ―腸管評価の新たなモダリティーはIBD診療を変えるかー (2014)
  • Author(s): 藤井俊光
  • Journal Title: INTESTINE Volume: 18 Pages: 159-166
• [Journal Article] 内科疾患最新の治療 明日への指針 第2章消化器 Crohn病 (2014)
  • Author(s): 藤井俊光, 渡辺守
  • Journal Title: 内科 Volume: 113 Pages: 1062-1065
• [Presentation] MR enterocolonography can detect small bowel strictures and predict surgery in patients with Crohn’s disease: Comparison with balloon enteroscopy. (2016)
  • Author(s): Toshimitsu Fujii, Kento Takenaka, Yoshio Kitazume, Maiko Kimura, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Organizer: APDW 2016 Kobe
  • Place of Presentation: 神戸コンベンションセンター（神戸）
  • Year and Date: 2016-11-03
  • Int'l Joint Research
• [Presentation] MR enterocolonography evaluation for small bowel strictures in patients with Crohn’s disease: comparison with balloon enteroscopy. (2016)
  • Author(s): Toshimitsu Fujii, Kento Takenaka, Yoshio Kitazume, Maiko Kimura, Tadahiko Iwamoto, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Organizer: UEG Week 2016 Vienna
  • Place of Presentation: Vienna（Austria）
  • Year and Date: 2016-10-18
  • Int'l Joint Research
• [Presentation] The evaluation for small bowel strictures on MR enterocolonography in patients with Crohn’s disease. (2016)
  • Author(s): Toshimitsu Fujii, Kento Takenaka, Maiko Kimura, Katsuyoshi Matusoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Organizer: AOCC 2016 The 4th Annual Meeting of Asian Organization for Crohn’s and Colitis
  • Place of Presentation: 国立京都国際会議場（京都府京都市）
  • Year and Date: 2016-06-19
  • Int'l Joint Research
• [Presentation] パネルディスカッション3 IBDモニタリングツールをいかに使いこなすか？ PD3-12 MRenterocolonography（MREC）の開発とクローン病診療における疾患活動性モニタリングツールとしての応用 (2016)
  • Author(s): 藤井俊光、大塚和朗、渡辺守
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2016-04-23
• [Presentation] Efficacy and safety of sequential rescue therapy with infliximab and tacrolimus in patients with corticosteroid-refractory ulcerative colitis. (2016)
  • Author(s): Matsuoka K, Saito E, Fujii T, Takenaka K, Iwamoto F, Kimura M, Nagahori M, Ohtsuka K, Watanabe M
  • Organizer: ECCO2016
  • Place of Presentation: Amsterdam（The Netherlands）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Enteroscopic and MR findings of small intestine in Crohn’s disease (2015)
  • Author(s): Toshimitsu Fujii, Kento Takenaka, Yoshio Kitazume, Maiko Kimura, Tadahiko Iwamoto, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Organizer: UEGW2015（欧州消化器病学会週間）
  • Place of Presentation: Barcelona（Spain）
  • Year and Date: 2015-10-28
  • Int'l Joint Research
• [Presentation] Epithelial TNFR2 signaling in the setting of IBD may be involved in the development of colitis-associated carcinogenesis. (2015)
  • Author(s): Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Kawai R, Totsuka M, Watanabe M
  • Organizer: UEG Week 2015
  • Place of Presentation: Barcelona（Spain）
  • Year and Date: 2015-10-28
  • Int'l Joint Research
• [Presentation] Epithelial type 2 TNF reseptor-specific signaling in the development of colitis-associated carcinogenesis. (2015)
  • Author(s): Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Watanabe M
  • Organizer: ICMI 2015
  • Place of Presentation: Berlin（Germany）
  • Year and Date: 2015-07-16
  • Int'l Joint Research
• [Presentation] TNFR2 signaling in colonic epithelia may be involved in the development of colitisassociated carcinogenesis. (2015)
  • Author(s): Hosoya A, Nagaishi T, Watabe T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Kawai L, Watanabe M
  • Organizer: The 3rd Annual Meeting of Asian Organization for Crohn's and Colitis
  • Place of Presentation: 北京（中国）
  • Year and Date: 2015-06-20
  • Int'l Joint Research
• [Presentation] Modifying and validating endoscopic and magnetic resonance scoring systems for the deep small intestine in Crohn’s disease. (2015)
  • Author(s): Fujii T, Takenaka K, Kitazume Y, Saito E, Matusoka K, Nagahori M, Ohtsuka K, Watanabe M
  • Organizer: The 3rd Annual Meeting of Asian Organization for Crohn’s and Colitis (AOCC)
  • Place of Presentation: 北京（中国）
  • Year and Date: 2015-06-19
  • Int'l Joint Research
• [Presentation] Modifying and validating endoscopic and magnetic resonance scoring systems for the deep small intestine in Crohn’s disease. (2015)
  • Author(s): Fujii T, Takenaka K, Kitazume Y, Saito E, Matusoka K, Nagahori M, Ohtsuka K, Watanabe M
  • Organizer: DDW2015（米国消化器病学会週間）
  • Place of Presentation: Washington, DC（USA）
  • Year and Date: 2015-04-25
  • Int'l Joint Research
• [Presentation] The ulcerative colitis endoscopic Index of severity (UCEIS) is useful to evaluate endoscopic improvement and to predict medium-term prognosis in ulcerative colitis patients treated with tacrolimus. (2015)
  • Author(s): Matsuoka K, Saito E, Fujii T, Takenaka K, Nagahori M, Ohtsuka K, Watanabe M
  • Organizer: European Crohn’s and Colitis Organization 2015
  • Place of Presentation: バルセロナ (スペイン)
  • Year and Date: 2015-02-20
• [Presentation] クローン病における内視鏡的粘膜治癒とMRenterocolonography（MREC）活動性の関係と長期予後についての検討 (2015)
  • Author(s): 藤井俊光、北詰良雄、竹中健人、齊藤詠子、長堀正和、大塚和朗、渡辺守
  • Organizer: 第11回日本消化管学会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2015-02-13
• [Presentation] 潰瘍性大腸炎におけるインフリキシマブ（IFX）濃度と短期の治療効果に関する検討. (2015)
  • Author(s): 齊藤詠子、長堀正和、竹中健人、藤井俊光、大塚和朗、渡辺 守
  • Organizer: 第11回日本消化管学会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2015-02-13
• [Presentation] 大腸上皮細胞特異的なTNFシグナルによるIBD合併大腸癌発生機構の解析. (2015)
  • Author(s): 永石宇司、渡部太郎、鈴木雅博、Jose Nisha、東海有沙、細谷明徳、鬼澤道夫、中村哲也、渡辺守
  • Organizer: 第11回日本消化管学会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2015-02-13
• [Presentation] クローン病におけるMRenterocolonography（MREC）での疾患活動性評価と予後予測 (2014)
  • Author(s): 藤井俊光、北詰良雄、齊藤詠子、竹中健人、松岡克善、長堀正和、大塚和朗、渡辺守
  • Organizer: 第6回日本炎症性腸疾患研究会学術集会
  • Place of Presentation: TKPガーデンシティ品川（東京都）
  • Year and Date: 2014-12-14
• [Presentation] TNFR2 signaling in the epithelia may be involved in the development of colitis-associated tumor. (2014)
  • Author(s): Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Totsuka M, Yagita H, Watanabe M
  • Organizer: 第43回日本免疫学会総会学術集会
  • Place of Presentation: 京都国立国際会議場 (京都府)
  • Year and Date: 2014-12-12
• [Presentation] クローン病におけるMRenterocolonography（MREC）での病態評価と長期予後の関連 (2014)
  • Author(s): 藤井俊光、北詰良雄、齊藤詠子、長堀正和、大塚和朗、渡辺守
  • Organizer: 第52回小腸研究会
  • Place of Presentation: ホテル東京ガーデンパレス（東京都）
  • Year and Date: 2014-11-15
• [Presentation] クローン病におけるMRenterocolonography（MREC）での病態評価と入院・手術予測 (2014)
  • Author(s): 藤井俊光、長堀正和、渡辺守
  • Organizer: JDDW2014 第56回日本消化器病学会大会
  • Place of Presentation: 神戸国際会議場（兵庫県・神戸市）
  • Year and Date: 2014-10-23
• [Presentation] The expression of myosin light chain kinase induced by NF-kB activation is involved in the development of colitis-associated cancer. (2014)
  • Author(s): Jose N, Nagaishi T, Watabe T, Tokai A, Suzuki M, Yamazaki M, Watanabe M
  • Organizer: UEG Week 2014 Vienna
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2014-10-22
• [Presentation] MR enterocolonography can identify patients who need additional treatment by predicting recurrence, hospitalization and surgery of Crohn’s disease patients in remission. (2014)
  • Author(s): Toshimitsu Fujii, Makoto Naganuma, Yoshio Kitazume, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Organizer: UEG Week 2014 Vienna
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2014-10-20
• [Presentation] Magnetic resonance enterocolonography can detect small intestinal active lesions in Crohn’s disease; comparison with balloon enteroscopy. (2014)
  • Author(s): Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Watanabe M
  • Organizer: UEG Week 2014 Vienna
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2014-10-20
• [Presentation] Epithelial MLCK induced via NF-kB activation may be involved in the development of colitis-associated carcinogenesis. (2014)
  • Author(s): Taro Watabe, Takashi Nagaishi1, Masahiro Suzuki1, Motomi Yamazaki, Nisha Jose1, Arisa Tokai1, Mamoru Watanabe
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2014-09-27
• [Presentation] Comparison of magnetic resonance and balloon enteroscopic examination of deep small intestine inpatients with Crohn’s disease. (2014)
  • Author(s): Takenaka K, Otsuka K, Nagahori M, Fujii T, Saito E, Watanabe M
  • Organizer: Asian Organization for Crohn’s and Colitis 2014
  • Place of Presentation: ソウル (韓国)
  • Year and Date: 2014-06-20
• [Presentation] The consecutive salvage therapy of tacrolimus and infliximab is effective in patients with refractory ulcerative colitis accompanied by acceptable adverse operative outcomes. (2014)
  • Author(s): Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Organizer: DDW/AGA 2014 Chicago
  • Place of Presentation: シカゴ（米国）
  • Year and Date: 2014-05-04
• [Presentation] IBD合併大腸癌モデルの発生過程における上皮細胞特異的TNFシグナルの解析. (2014)
  • Author(s): 鈴木雅博、永石宇司、鬼澤道夫、山崎元美、渡辺 守
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2014-04-25
• [Book] JMEDJ治療法便覧2016～私の治療～ 潰瘍性大腸炎 (2017)
  • Author(s): 藤井俊光、渡辺守
  • Publisher: 日本医事新報社
• [Book] 診断・モニタリング・サーベイランス 実臨床に役立つIBD内視鏡 (2016)
  • Author(s): 藤井 俊光
  • Total Pages: 264
  • Publisher: 日本メディカルセンター
• [Book] クローン病のImaging アトラス クローン病典型例 小腸病変 内視鏡・MR 炎症性腸疾患Imaging Atlas－診断の極意と鑑別のポイント (2016)
  • Author(s): 藤井 俊光
  • Total Pages: 230
  • Publisher: 日本メディカルセンター
• [Book] 消化器研修ノート 改訂第2版 第4章 C-1 X線検査―上部消化管・小腸 (2016)
  • Author(s): 藤井 俊光
  • Total Pages: 708
  • Publisher: 診断と治療社
• [Book] Paradigm of T cell differentiation in IBD: Crohn's disease and ulcerative colitis. / Crohn's Disease and Ulcerative Colitis (2016)
  • Author(s): Nagaishi T,Watanabe M
  • Publisher: Springer
• [Book] 炎症性腸疾患―生物学的製剤の課題と展望 / 消化器疾患 最新の治療 2015-2016 (2015)
  • Author(s): 藤井俊光、渡辺 守
  • Total Pages: 512
  • Publisher: 南江堂
• [Book] II.病気・病態に応じた使い方 5.消化器疾患患者に投与するときの注意 / 一冊できわめるステロイド診療ガイド (2015)
  • Author(s): 藤井俊光、中村哲也
  • Total Pages: 304
  • Publisher: 文光堂
• [Book] 2章 消化器疾患別Q＆A 潰瘍性大腸炎、Crohn病 / 消化管疾患診療のギモン・シツモン・アンコモン (2015)
  • Author(s): 藤井俊光、渡辺 守
  • Total Pages: 160
  • Publisher: 日本医事新報社
• [Book] 治療薬の使い方 コツと落とし穴 その他の治療「現在開発中の新規治療」 / チェックリストで分かる! IBD治療薬の選び方・使い方 重症度と患者背景から導く炎症性腸疾患の処方 (2015)
  • Author(s): 藤井俊光、渡辺 守
  • Total Pages: 262
  • Publisher: 羊土社
• [Book] 消化器疾患 最新の治療 2015-2016 （巻頭3. 炎症性腸疾患―生物学的製剤の課題と展望 Page12-17） (2015)
  • Author(s): 藤井俊光、渡辺守
  • Total Pages: 512
  • Publisher: 南江堂
• [Book] 実践！IBD診療 （スーパーバイザー’S アドバイス NSAIDsはIBDを悪くする？ Page184-185） (2014)
  • Author(s): 藤井俊光
  • Total Pages: 224
  • Publisher: 医学出版
• [Book] これで納得！画像で見ぬく消化器疾患 vol.3小腸 （A 正常小腸と診断機器 8 MRI Page50-52） (2014)
  • Author(s): 藤井俊光
  • Total Pages: 168
  • Publisher: 医学出版
• [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物 (2016)
  • Inventor(s): 永石宇司、渡辺守、久場敬司
  • Industrial Property Rights Holder: 東京医科歯科大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-234062
  • Filing Date: 2016-12-01