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Development of new treatment with trafficking modulation of colitogenic memory lymphocytes.

Research Project

Project/Area Number 26460963
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

FUJII TOSHIMITSU  東京医科歯科大学, 医学部附属病院, 助教 (30547451)

Co-Investigator(Kenkyū-buntansha) 永石 宇司  東京医科歯科大学, 医学部附属病院, 助教 (60447464)
渡辺 守 (渡邉 守)  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords下部消化管学 / 炎症性腸疾患 / 新規治療 / 腸管免疫 / リンパ球動態制御 / 下部消化管学(小腸、大腸)
Outline of Final Research Achievements

Fingolimod is a sphingosine-1-phosphate receptor modulator, which inhibits T cell egress from lymph nodes, thereby prevents pathogenic T cells from migrating towards disease sites. In inflammatory bowel diseases (IBD), it is thought that colitogenic memory T cells are reactivated in regional lymphoid organs, and return to inflammatory tissues. We demonstrated that fingolimod prevents the development of colitis induced by the adoptive transfer of naive T cells (naive T colitis) and colitogenic effector-memory T cells (memory T colitis) into SCID mice. Next, we demonstrated that fingolimod decreased T cells in peripheral blood, but conversely increased in bone marrow in the mice lacking lymph nodes and spleen. Notably, fingolimod prevented the development of memory T colitis without lymph nodes and spleen. Collectively, fingolimod may offer an additional role to direct trafficking of T cells in bone marrow, resulting in the prevention of memory T cell-mediated diseases including IBD.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (56 results)

All 2017 2016 2015 2014

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (26 results) (of which Int'l Joint Research: 10 results) Book (12 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy.2017

    • Author(s)
      Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Fujioka T, Araki A, Watanabe M.
    • Journal Title

      J Gastroenterol.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic features and genetic background of inflammatory bowel disease complicated with Takayasu arteritis.2017

    • Author(s)
      Akiyama S, Fujii T, Matsuoka K, Yusuke E, Negi M, Takenaka K, Nagahori M, Ohtsuka K, Isobe M, Watanabe M.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 32 Issue: 5 Pages: 1011-1017

    • DOI

      10.1111/jgh.13640

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial Nuclear Factor-kB Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis. "2016

    • Author(s)
      Nagaishi T,Watabe T,Jose N, Tokai A, Fujii T, Matsuoka K, Nagahori M, Ohtsuka K
    • Journal Title

      Digestion

      Volume: 93 Issue: 1 Pages: 40-46

    • DOI

      10.1159/000441670

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn's disease.2016

    • Author(s)
      Ohtsuka K, Takenaka K, Kitazume Y, Fujii T, Matsuoka K, Kimura M, Nagaishi T, Watanabe M.
    • Journal Title

      Intest Res.

      Volume: 14 Issue: 2 Pages: 120-126

    • DOI

      10.5217/ir.2016.14.2.120

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development.2016

    • Author(s)
      Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Memoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 36780-36780

    • DOI

      10.1038/srep36780

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tacrolimus for the Treatment of Ulcerative Colitis.2015

    • Author(s)
      Matsuoka K, Saito E, Fujii T, Takenaka K, Kimura M, Nagahori M, Ohtsuka K, Watanabe M.
    • Journal Title

      Intest Res.

      Volume: 13 Issue: 3 Pages: 219-226

    • DOI

      10.5217/ir.2015.13.3.219

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.2015

    • Author(s)
      Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
    • Journal Title

      Autophagy

      Volume: 11 Issue: 7 Pages: 1052-1062

    • DOI

      10.1080/15548627.2015.1055439

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] クローン病画像モダリティとしてのMRI2015

    • Author(s)
      藤井俊光、渡辺 守
    • Journal Title

      日本消化器病学会雑誌

      Volume: 112 Pages: 15-22

    • NAID

      130005084744

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation of the endoscopic and magnetic resonance scoring systems in the deep small intestine in Crohn’s disease.2015

    • Author(s)
      Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Fujioka T, Matsuoka K, Naganuma M, Watanabe M
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 未

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] New Technology MRIによる腸管評価法2015

    • Author(s)
      藤井俊光
    • Journal Title

      Medical Science Digest

      Volume: 41 Pages: 199-200

    • Related Report
      2014 Research-status Report
  • [Journal Article] Advancing magnetic resonance imaging in Crohn's disease.2014

    • Author(s)
      Fujii T, Naganuma M, Kitazume Y, Saito E, Nagahori M, Ohtsuka K, Watanabe M.
    • Journal Title

      Digestion

      Volume: 89 Issue: 1 Pages: 24-30

    • DOI

      10.1159/000356210

    • NAID

      130005084744

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of Magnetic Resonance and Balloon Enteroscopic Examination of Deep Small Intestine in Patients with Crohn's Disease.2014

    • Author(s)
      Takenaka K, Ohtsuka K,Watanabe M et al
    • Journal Title

      Gastroenterology

      Volume: [Epub ahead of print] Issue: 2 Pages: 334-342

    • DOI

      10.1053/j.gastro.2014.04.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis.2014

    • Author(s)
      Saito E, Nagahori M, Fujii T, Otsuka K, Watanabe M
    • Journal Title

      Digestion

      Volume: 89 Issue: 1 Pages: 55-60

    • DOI

      10.1159/000356221

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis.2014

    • Author(s)
      Suzuki M, Nagaishi T, Yamazaki M, Onizawa M, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 2 Pages: e88369-e88369

    • DOI

      10.1371/journal.pone.0088369

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.2014

    • Author(s)
      Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 456(1) Issue: 1 Pages: 298-304

    • DOI

      10.1016/j.bbrc.2014.11.075

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 炎症性腸疾患の画像診断 modality IV. MRI ―腸管評価の新たなモダリティーはIBD診療を変えるかー2014

    • Author(s)
      藤井俊光
    • Journal Title

      INTESTINE

      Volume: 18 Pages: 159-166

    • Related Report
      2014 Research-status Report
  • [Journal Article] 内科疾患最新の治療 明日への指針 第2章消化器 Crohn病2014

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      内科

      Volume: 113 Pages: 1062-1065

    • Related Report
      2014 Research-status Report
  • [Presentation] MR enterocolonography can detect small bowel strictures and predict surgery in patients with Crohn’s disease: Comparison with balloon enteroscopy.2016

    • Author(s)
      Toshimitsu Fujii, Kento Takenaka, Yoshio Kitazume, Maiko Kimura, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Organizer
      APDW 2016 Kobe
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MR enterocolonography evaluation for small bowel strictures in patients with Crohn’s disease: comparison with balloon enteroscopy.2016

    • Author(s)
      Toshimitsu Fujii, Kento Takenaka, Yoshio Kitazume, Maiko Kimura, Tadahiko Iwamoto, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Organizer
      UEG Week 2016 Vienna
    • Place of Presentation
      Vienna(Austria)
    • Year and Date
      2016-10-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The evaluation for small bowel strictures on MR enterocolonography in patients with Crohn’s disease.2016

    • Author(s)
      Toshimitsu Fujii, Kento Takenaka, Maiko Kimura, Katsuyoshi Matusoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Organizer
      AOCC 2016 The 4th Annual Meeting of Asian Organization for Crohn’s and Colitis
    • Place of Presentation
      国立京都国際会議場(京都府京都市)
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] パネルディスカッション3 IBDモニタリングツールをいかに使いこなすか? PD3-12 MRenterocolonography(MREC)の開発とクローン病診療における疾患活動性モニタリングツールとしての応用2016

    • Author(s)
      藤井俊光、大塚和朗、渡辺守
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Efficacy and safety of sequential rescue therapy with infliximab and tacrolimus in patients with corticosteroid-refractory ulcerative colitis.2016

    • Author(s)
      Matsuoka K, Saito E, Fujii T, Takenaka K, Iwamoto F, Kimura M, Nagahori M, Ohtsuka K, Watanabe M
    • Organizer
      ECCO2016
    • Place of Presentation
      Amsterdam(The Netherlands)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Enteroscopic and MR findings of small intestine in Crohn’s disease2015

    • Author(s)
      Toshimitsu Fujii, Kento Takenaka, Yoshio Kitazume, Maiko Kimura, Tadahiko Iwamoto, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Organizer
      UEGW2015(欧州消化器病学会週間)
    • Place of Presentation
      Barcelona(Spain)
    • Year and Date
      2015-10-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Epithelial TNFR2 signaling in the setting of IBD may be involved in the development of colitis-associated carcinogenesis.2015

    • Author(s)
      Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Kawai R, Totsuka M, Watanabe M
    • Organizer
      UEG Week 2015
    • Place of Presentation
      Barcelona(Spain)
    • Year and Date
      2015-10-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Epithelial type 2 TNF reseptor-specific signaling in the development of colitis-associated carcinogenesis.2015

    • Author(s)
      Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Watanabe M
    • Organizer
      ICMI 2015
    • Place of Presentation
      Berlin(Germany)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] TNFR2 signaling in colonic epithelia may be involved in the development of colitisassociated carcinogenesis.2015

    • Author(s)
      Hosoya A, Nagaishi T, Watabe T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Kawai L, Watanabe M
    • Organizer
      The 3rd Annual Meeting of Asian Organization for Crohn's and Colitis
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modifying and validating endoscopic and magnetic resonance scoring systems for the deep small intestine in Crohn’s disease.2015

    • Author(s)
      Fujii T, Takenaka K, Kitazume Y, Saito E, Matusoka K, Nagahori M, Ohtsuka K, Watanabe M
    • Organizer
      The 3rd Annual Meeting of Asian Organization for Crohn’s and Colitis (AOCC)
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modifying and validating endoscopic and magnetic resonance scoring systems for the deep small intestine in Crohn’s disease.2015

    • Author(s)
      Fujii T, Takenaka K, Kitazume Y, Saito E, Matusoka K, Nagahori M, Ohtsuka K, Watanabe M
    • Organizer
      DDW2015(米国消化器病学会週間)
    • Place of Presentation
      Washington, DC(USA)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The ulcerative colitis endoscopic Index of severity (UCEIS) is useful to evaluate endoscopic improvement and to predict medium-term prognosis in ulcerative colitis patients treated with tacrolimus.2015

    • Author(s)
      Matsuoka K, Saito E, Fujii T, Takenaka K, Nagahori M, Ohtsuka K, Watanabe M
    • Organizer
      European Crohn’s and Colitis Organization 2015
    • Place of Presentation
      バルセロナ (スペイン)
    • Year and Date
      2015-02-20
    • Related Report
      2014 Research-status Report
  • [Presentation] クローン病における内視鏡的粘膜治癒とMRenterocolonography(MREC)活動性の関係と長期予後についての検討2015

    • Author(s)
      藤井俊光、北詰良雄、竹中健人、齊藤詠子、長堀正和、大塚和朗、渡辺守
    • Organizer
      第11回日本消化管学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2015-02-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 潰瘍性大腸炎におけるインフリキシマブ(IFX)濃度と短期の治療効果に関する検討.2015

    • Author(s)
      齊藤詠子、長堀正和、竹中健人、藤井俊光、大塚和朗、渡辺 守
    • Organizer
      第11回日本消化管学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2015-02-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸上皮細胞特異的なTNFシグナルによるIBD合併大腸癌発生機構の解析.2015

    • Author(s)
      永石宇司、渡部太郎、鈴木雅博、Jose Nisha、東海有沙、細谷明徳、鬼澤道夫、中村哲也、渡辺守
    • Organizer
      第11回日本消化管学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2015-02-13
    • Related Report
      2014 Research-status Report
  • [Presentation] クローン病におけるMRenterocolonography(MREC)での疾患活動性評価と予後予測2014

    • Author(s)
      藤井俊光、北詰良雄、齊藤詠子、竹中健人、松岡克善、長堀正和、大塚和朗、渡辺守
    • Organizer
      第6回日本炎症性腸疾患研究会学術集会
    • Place of Presentation
      TKPガーデンシティ品川(東京都)
    • Year and Date
      2014-12-14
    • Related Report
      2014 Research-status Report
  • [Presentation] TNFR2 signaling in the epithelia may be involved in the development of colitis-associated tumor.2014

    • Author(s)
      Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Totsuka M, Yagita H, Watanabe M
    • Organizer
      第43回日本免疫学会総会学術集会
    • Place of Presentation
      京都国立国際会議場 (京都府)
    • Year and Date
      2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] クローン病におけるMRenterocolonography(MREC)での病態評価と長期予後の関連2014

    • Author(s)
      藤井俊光、北詰良雄、齊藤詠子、長堀正和、大塚和朗、渡辺守
    • Organizer
      第52回小腸研究会
    • Place of Presentation
      ホテル東京ガーデンパレス(東京都)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] クローン病におけるMRenterocolonography(MREC)での病態評価と入院・手術予測2014

    • Author(s)
      藤井俊光、長堀正和、渡辺守
    • Organizer
      JDDW2014 第56回日本消化器病学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2014-10-23
    • Related Report
      2014 Research-status Report
  • [Presentation] The expression of myosin light chain kinase induced by NF-kB activation is involved in the development of colitis-associated cancer.2014

    • Author(s)
      Jose N, Nagaishi T, Watabe T, Tokai A, Suzuki M, Yamazaki M, Watanabe M
    • Organizer
      UEG Week 2014 Vienna
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2014-10-22
    • Related Report
      2014 Research-status Report
  • [Presentation] MR enterocolonography can identify patients who need additional treatment by predicting recurrence, hospitalization and surgery of Crohn’s disease patients in remission.2014

    • Author(s)
      Toshimitsu Fujii, Makoto Naganuma, Yoshio Kitazume, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Organizer
      UEG Week 2014 Vienna
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2014-10-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Magnetic resonance enterocolonography can detect small intestinal active lesions in Crohn’s disease; comparison with balloon enteroscopy.2014

    • Author(s)
      Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Watanabe M
    • Organizer
      UEG Week 2014 Vienna
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2014-10-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Epithelial MLCK induced via NF-kB activation may be involved in the development of colitis-associated carcinogenesis.2014

    • Author(s)
      Taro Watabe, Takashi Nagaishi1, Masahiro Suzuki1, Motomi Yamazaki, Nisha Jose1, Arisa Tokai1, Mamoru Watanabe
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Comparison of magnetic resonance and balloon enteroscopic examination of deep small intestine inpatients with Crohn’s disease.2014

    • Author(s)
      Takenaka K, Otsuka K, Nagahori M, Fujii T, Saito E, Watanabe M
    • Organizer
      Asian Organization for Crohn’s and Colitis 2014
    • Place of Presentation
      ソウル (韓国)
    • Year and Date
      2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] The consecutive salvage therapy of tacrolimus and infliximab is effective in patients with refractory ulcerative colitis accompanied by acceptable adverse operative outcomes.2014

    • Author(s)
      Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Organizer
      DDW/AGA 2014 Chicago
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2014-05-04
    • Related Report
      2014 Research-status Report
  • [Presentation] IBD合併大腸癌モデルの発生過程における上皮細胞特異的TNFシグナルの解析.2014

    • Author(s)
      鈴木雅博、永石宇司、鬼澤道夫、山崎元美、渡辺 守
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Book] JMEDJ治療法便覧2016~私の治療~ 潰瘍性大腸炎2017

    • Author(s)
      藤井俊光、渡辺守
    • Publisher
      日本医事新報社
    • Related Report
      2016 Annual Research Report
  • [Book] 診断・モニタリング・サーベイランス 実臨床に役立つIBD内視鏡2016

    • Author(s)
      藤井 俊光
    • Total Pages
      264
    • Publisher
      日本メディカルセンター
    • Related Report
      2016 Annual Research Report
  • [Book] クローン病のImaging アトラス クローン病典型例 小腸病変 内視鏡・MR 炎症性腸疾患Imaging Atlas-診断の極意と鑑別のポイント2016

    • Author(s)
      藤井 俊光
    • Total Pages
      230
    • Publisher
      日本メディカルセンター
    • Related Report
      2016 Annual Research Report
  • [Book] 消化器研修ノート 改訂第2版 第4章 C-1 X線検査―上部消化管・小腸2016

    • Author(s)
      藤井 俊光
    • Total Pages
      708
    • Publisher
      診断と治療社
    • Related Report
      2016 Annual Research Report
  • [Book] Paradigm of T cell differentiation in IBD: Crohn's disease and ulcerative colitis. / Crohn's Disease and Ulcerative Colitis2016

    • Author(s)
      Nagaishi T,Watanabe M
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Book] 炎症性腸疾患―生物学的製剤の課題と展望 / 消化器疾患 最新の治療 2015-20162015

    • Author(s)
      藤井俊光、渡辺 守
    • Total Pages
      512
    • Publisher
      南江堂
    • Related Report
      2015 Research-status Report
  • [Book] II.病気・病態に応じた使い方 5.消化器疾患患者に投与するときの注意 / 一冊できわめるステロイド診療ガイド2015

    • Author(s)
      藤井俊光、中村哲也
    • Total Pages
      304
    • Publisher
      文光堂
    • Related Report
      2015 Research-status Report
  • [Book] 2章 消化器疾患別Q&A 潰瘍性大腸炎、Crohn病 / 消化管疾患診療のギモン・シツモン・アンコモン2015

    • Author(s)
      藤井俊光、渡辺 守
    • Total Pages
      160
    • Publisher
      日本医事新報社
    • Related Report
      2015 Research-status Report
  • [Book] 治療薬の使い方 コツと落とし穴 その他の治療「現在開発中の新規治療」 / チェックリストで分かる! IBD治療薬の選び方・使い方 重症度と患者背景から導く炎症性腸疾患の処方2015

    • Author(s)
      藤井俊光、渡辺 守
    • Total Pages
      262
    • Publisher
      羊土社
    • Related Report
      2015 Research-status Report
  • [Book] 消化器疾患 最新の治療 2015-2016 (巻頭3. 炎症性腸疾患―生物学的製剤の課題と展望 Page12-17)2015

    • Author(s)
      藤井俊光、渡辺守
    • Total Pages
      512
    • Publisher
      南江堂
    • Related Report
      2014 Research-status Report
  • [Book] 実践!IBD診療 (スーパーバイザー’S アドバイス NSAIDsはIBDを悪くする? Page184-185)2014

    • Author(s)
      藤井俊光
    • Total Pages
      224
    • Publisher
      医学出版
    • Related Report
      2014 Research-status Report
  • [Book] これで納得!画像で見ぬく消化器疾患 vol.3小腸 (A 正常小腸と診断機器 8 MRI Page50-52)2014

    • Author(s)
      藤井俊光
    • Total Pages
      168
    • Publisher
      医学出版
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物2016

    • Inventor(s)
      永石宇司、渡辺守、久場敬司
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-234062
    • Filing Date
      2016-12-01
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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