| Project/Area Number |
26460966
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Ban Hiromitsu 滋賀医科大学, 医学部, 特任助教 (30598363)
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| Co-Investigator(Kenkyū-buntansha) |
馬場 重樹 滋賀医科大学, 医学部, 助教 (40422901)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 炎症性腸疾患 / サイトカイン / アンチセンスオリゴ / Interleukin-17 / DSS腸炎マウス / インターロイキン / 炎症性サイトカイン / 腸炎モデルマウス / 抗炎症作用 |
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| Outline of Final Research Achievements |
IL-17β is highly expressed from Dectin-1 positive cells with IL-1β. In addition, we have studied the introduction of antisense DNA nucleotide sequences into cells using β-1,3-D-gulcan, Schizophyllan as a carrier, in a Dectin-1 dependent manner. Based on these two studies, IL-17F highly expressed from Dectin-1 positive cells in intestinal inflammation model mice was suppressed by intracellular introduction of antisense DNA by using SPG-mediated Drug delivery system We will elucidate the role of IL-17F expressed from Dectin-1 positive cells and aim to develop new therapeutic agents for inflammatory bowel disease.
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