Activation of insulin-like growth factor as a biomarker for cancer development and growth

• Project/Area Number: 26460968
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: Shin'ichi Miyamoto 京都大学, 医学研究科, 助教 (90378761)
• Research Collaborator: SETOYAMA TAKESHI 京都大学, 医学部附属病院がんセンター, 医員 (80760595)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: インスリン様増殖因子 / バイオマーカー / 分子標的治療 / 非膵島細胞腫瘍性低血糖 / 活性型インスリン様増殖因子 / 肝転移 / 非膵島腫瘍性低血糖 / 中和抗体 / 分子標的療法

Outline of Final Research Achievements

We have been reported the usefulness of insulin-like growth factor (IGF) as a therapeutic target using IGF neutralizing antibody. This antibody can neutralize only bioactive IGF activated in the tumor microenvironment and does not affect the physiological molecular form, IGF-IGF binding protein complex. This characteristics of antibody can lead to not only reduction of the systemic adverse effect but also tumor-specific drug delivery. It is essential for the accurate dosage adjustment and prediction of therapeutic and adverse effect to measure the level of bioactive IGF. We successfully develop the novel assay for the detection of bioactive IGF in the blood. Furthermore, we clarified that bioactive IGF-2 was elevated in a case of tumor-associated hypoglycemia except insulin-producing tumor using this assay.

Research Products

• [Journal Article] Esophageal Rupture Associated with Colonoscopy Preparation. (2016)
  • Author(s): Nishikawa Y, Miyamoto S, Horimatsu T, Okabe H, Muto M.
  • Journal Title: J Am Geriatr Soc. Volume: 64 Issue: 3 Pages: 682-683
  • DOI: 10.1111/jgs.14003
  • Peer Reviewed
• [Journal Article] Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma. (2016)
  • Author(s): Kikuchi, O, Ohashi, S, Horibe, T, Kohno, M, Nakai, Y, Miyamoto, S, Chiba, T, Muto, M and Kawakami, K
  • Journal Title: Scientific reports Volume: 6 Issue: 1 Pages: 22452-22452
  • DOI: 10.1038/srep22452
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Multiple White Plaques in the Body of the Stomach in a Patient Undergoing Hemodialysis. (2016)
  • Author(s): Nishikawa Y, Sakurai T, Miyamoto S.
  • Journal Title: Gastroenterology. Volume: 151 Issue: 1 Pages: e18-e19
  • DOI: 10.1053/j.gastro.2016.03.049
  • Peer Reviewed
• [Journal Article] Concomitant Case of Intraductal Papillary Mucinous Neoplasm of the Pancreas and Functioning Pancreatic Neuroendocrine Tumor (Vasoactive Intestinal Polypeptide-Producing Tumor): First Report. (2016)
  • Author(s): Ishizu S, Setoyama T, Ueo T, Ueda Y, Kodama Y, Ida H, Kawaguchi Y, Yoshizawa A, Chiba T, Miyamoto S.
  • Journal Title: Pancreas. Volume: 45 Issue: 6 Pages: e24-e25
  • DOI: 10.1097/mpa.0000000000000578
  • Peer Reviewed
• [Journal Article] Endoscopic laryngo-pharyngeal surgery for superficial laryngo-pharyngeal cancer. (2016)
  • Author(s): Tateya I, Muto M, Morita S, Miyamoto S, Hayashi T, Funakoshi M, Aoyama I, Higuchi H, Hirano S, Kitamura M, Ishikawa S, Kishimoto Y, Morita M, Ito J.
  • Journal Title: Surg Endosc. Volume: 30 Issue: 1 Pages: 323-329
  • DOI: 10.1007/s00464-015-4213-y
  • Peer Reviewed
• [Journal Article] Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression. (2015)
  • Author(s): .Kikuchi O, Ohashi S, Nakai Y, Nakagawa S, Matsuoka K, Kobunai T, Takechi T,
  • Journal Title: Am J Cancer Res Volume: 5 Pages: 2431-2440
  • Peer Reviewed / Open Access
• [Journal Article] Instability of IGF-IGFBP complex as a cause of the different performance of serum and EDTA-plasma after storage: EDTA-plasma is preferable for evaluating bioactive IGF especially in the mouse. (2015)
  • Author(s): Setoyama T, Miyamoto S, Nikaido M, Muto M, Chiba T.
  • Journal Title: Growth Horm IGF Res. Volume: 25 Issue: 5 Pages: 227-231
  • DOI: 10.1016/j.ghir.2015.06.009
  • Peer Reviewed
• [Journal Article] Recent Advances from Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma. (2015)
  • Author(s): Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y, Muto M.
  • Journal Title: Gastroenterology Volume: 149 Issue: 7 Pages: 1700-1715
  • DOI: 10.1053/j.gastro.2015.08.054
  • NAID: 120005848418
  • Peer Reviewed / Open Access
• [Journal Article] Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium (2015)
  • Author(s): Amanuma Y, Ohashi S, Itatani Y, Tsurumaki M, Matsuda S, Kikuchi1 O, Naka Y, Miyamoto S, Oyama T, Kawamoto T, Whelan KA, Nakagawa H, Chiba T, Matsuda T, Muto M
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 14142-14142
  • DOI: 10.1038/srep14142
  • NAID: 120005678158
  • Peer Reviewed / Open Access
• [Journal Article] Prevention of Gastric Volvulus-induced Recurrent Acute Pancreatitis by Percutaneous Endoscopic Gastropexy. (2015)
  • Author(s): Nikaido M, Miyamoto S, Iinuma S.
  • Journal Title: Clin Gastroenterol Hepatol Volume: 13 Issue: 2 Pages: e11-e12
  • DOI: 10.1016/j.cgh.2014.09.035
  • Peer Reviewed / Open Access
• [Journal Article] Multimodal endoscopic treatment for delayed severe esophageal stricture caused by incomplete stent removal (2014)
  • Author(s): Setoyma T, Miyamoto S, Horimatsu T, Morita S, Ezoe Y, Muto M, Watanabe G, Tanaka E, Chiba T
  • Journal Title: Dis Esophagus Volume: 2 Issue: 2 Pages: 7112-115
  • DOI: 10.1111/dote.12041
  • Peer Reviewed
• [Journal Article] Bioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia. (2014)
  • Author(s): Setoyama T, Miyamoto S, Horimatsu T, Funakoshi T, Nikaido M, Kodama Y, Minamiguchi S, Yamabata T, Muto M, Chiba T.
  • Journal Title: Cancer Biol Ther Volume: 15 Issue: 12 Pages: 1588-1592
  • DOI: 10.4161/15384047.2014.961878
  • Peer Reviewed
• [Journal Article] Systemic ulcerative lesions in a patient with ischemic heart disease. (2014)
  • Author(s): Nikaido M, Miyamoto S, Iinuma S.
  • Journal Title: Gastroenterology. Volume: 147 Issue: 6 Pages: e7-e8
  • DOI: 10.1053/j.gastro.2014.06.040
  • Peer Reviewed / Open Access
• [Presentation] 内視鏡治療後に再発を繰り返す胃管がんに光線力学療法が有効であった1例 (2015)
  • Author(s): 玉置将司
  • Organizer: 第95回消化器内視鏡学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-07
• [Presentation] 化学療法中にPeumocystis JiroveciおよびCytomegalovirusの重複肺炎を来した進行胃癌の一例 (2015)
  • Author(s): 伊賀健太朗
  • Organizer: 第53回日本がん治療学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2015-10-31
• [Presentation] 非膵島細胞腫瘍性低血糖に対する活性型インスリン様増殖因子を分子標的とした治療戦略 (2015)
  • Author(s): 瀬戸山健
  • Organizer: 第13回日本臨床腫瘍学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-07-17
• [Presentation] Bioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia (2015)
  • Author(s): 瀬戸山健
  • Organizer: 第13回日本臨床腫瘍学会
  • Place of Presentation: 札幌
  • Year and Date: 2015-07-16 – 2015-07-18
• [Remarks] 京都大学大学院 医学研究科 腫瘍薬物治療学講座
  • URL: http://oncology.kuhp.kyoto-u.ac.jp/research