| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Palmitoleic acid (PO) plays a role in the regulation of inflammation and insulin sensitivity in mice. To investigate its effects in inflammatory bowel disease, we evaluated PO levels in blood and mesenteric adipose tissue in patients with inflammatory bowel disease. Additionally, we evaluated if PO acid inhibited the inflammation associated with dextran sodium sulfate-induced colitis in mice.Serum PO levels (μg/ml) were significantly higher in patients with Crohn’s disease (69.6±7.5) than in patients with ulcerative colitis (51.2±5.1) or healthy volunteers (45.9±3.4); higher PO levels were identified in patients with hypertrophy of the mesenteric adipose tissue in Crohn’s disease (17.8±1.8) than in patients with colon cancer (7.9±1.4). In mice, PO administration significantly reduced the histological inflammatory grade of the colon. PO may be involved in the regulation of intestinal inflammation in inflammatory bowel disease.
|
