| Project/Area Number |
26460974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Shono Takashi 熊本大学, 医学部附属病院, 助教 (40632667)
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| Co-Investigator(Kenkyū-buntansha) |
渡邊 丈久 熊本大学, 大学院生命科学研究部(医), 助教 (20634843)
直江 秀昭 熊本大学, 医学部附属病院, 助教 (30599246)
佐々木 裕 熊本大学, 大学院生命科学研究部(医), 教授 (70235282)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 大腸癌 / 発癌 / 大腸ポリープ / 内視鏡 / 消化器 / miRNA / プロテオミクス / SSAP / 内視鏡治療 / ﾌﾟﾛﾃｵﾐｸｽ |
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| Outline of Final Research Achievements |
We resected 3 SSAPs with cancer in the proximal colon with use of endoscopic submucosal dissection (ESD). These specimens were divided into normal mucosa, SSAP and cancer, using with Laser Micro-Dissection method (LMD). DNA and RNA were extracted from each section, respectively. Especially, microRNA (miRNA) quantification was performed.
We molecularly analyzed extracted miRNAs and detected variable miRNAs in a characteristic manner during the process of carcinogenesis.
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