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Prediction of treatment efficacy for severe ulcerative colitis

Research Project

Project/Area Number 26460977
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKeio University

Principal Investigator

inoue nagamu  慶應義塾大学, 医学部(信濃町), 准教授 (00232546)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords潰瘍性大腸炎 / 炎症性腸疾患 / 治療 / 再燃 / 効果予測 / 内視鏡
Outline of Final Research Achievements

We explored the association of a variety of factors including endoscopic activity of patients in clinical remission with their long-term clinical outcome. Mayo endoscopic score 1 (hazard ratio (HR): 2.86) and score 2 (HR: 3.60) was significant risk factor for clinical relapse against endoscopic score 0. Univariate analysis also identified significant association with relapse for moderate clinical activity of last flare, remission induction with cytapheresis (CAP), maintenance with imuunomodulator, shorter duration of remission and higher histological activity. Cox regression analysis revealed that endoscopic activity, histological activity, duration of remission and remission induction with CAP were found to be independent determinants of relapse. The Kaplan-Meier estimate of non-relapse rate by endoscopic activity groups demonstrated significant difference. While there was significance between score 0 and 1, there were no significance between score 1 and 2.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] The Ulcerative Colitis Endoscopic Index of Severity is Useful to Predict Medium- to Long-Term Prognosis in Ulcerative Colitis Patients with Clinical Remission.2016

    • Author(s)
      Arai M, Naganuma M, Sugimoto S, Kiyohara H, Ono K, Mori K, Saigusa K, Nanki K, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hosoe N, Matsuoka K, Inoue N, Ogata H, Iwao Y, Kanai T
    • Journal Title

      J Crohns Colitis 10

      Volume: 10 Issue: 2 Pages: 1303-9

    • DOI

      10.1007/s00535-016-1209-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors for decreased bone mineral density in inflammatory bowel disease: A cross-sectional study.2015

    • Author(s)
      Wada Y, Hisamatsu T, Naganuma M, Matsuoka K, Okamoto S, Inoue N, Yajima T, Kouyama K, Iwao Y, Ogata H, Hibi T, Abe T, Kanai T
    • Journal Title

      Clin Nutr

      Volume: 34 Issue: 6 Pages: 1202-9

    • DOI

      10.1016/j.clnu.2015.01.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adalimumab for the treatment of Japanese patients with intestinal Behçet's disease.2015

    • Author(s)
      Tanida S, Inoue N, Kobayashi K, Naganuma M, Hirai F, Iizuka B, Watanabe K, Mitsuyama K, Inoue T, Ishigatsubo Y, Suzuki Y, Nagahori M, Motoya S, Nakamura S, Arora V, Robinson AM, Thakkar RB, Hibi T.
    • Journal Title

      Clin Gastroenterol Hepatol

      Volume: 13 Issue: 5 Pages: 940-948

    • DOI

      10.1016/j.cgh.2014.08.042

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk and Management of Intra-Abdominal Abscess in Crohn's Disease Treated with Infliximab2014

    • Author(s)
      Yoneno K, Hisamatsu T, Matsuoka K, Okamoto S, Takayama T, Ichikawa R, Sujino T, Miyoshi J, Takabayashi K, Mikami Y, Mizuno S, Wada Y, Yajima T, Naganuma M, Inoue N, Iwao Y, Ogata H, Hasegawa H, Kitagawa Y, Hibi T, Kanai T
    • Journal Title

      Digestion

      Volume: 89 Issue: 3 Pages: 201-208

    • DOI

      10.1159/000360618

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Aging, current smoking and metabolic factors are independently associated with the prevalence of colorectal neoplasia in Japan: analyses of comprehensive health checkup data2016

    • Author(s)
      Inoue N, Takayama M, Bessho R, Makino K, Shimizu-Hirota R, Yoshida T, Kashiwagi K, Yoshida T, Hirose H, Ogata H, Sugino Y, Iwao Y
    • Organizer
      24th United European Gastroenterology Week 2016
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic factors in addition to aging and current smoking are independently associated with the prevalence of colorectal neoplasia in Japan: Analyses if comprehensive heath checkup data.2016

    • Author(s)
      Inoue N, Takayama M, Makino K, Shiomi E, Shimizu-Hirota R, Yoshida T, Kashiwagi K, Hirose H, Momoshima S, Sugino Y, Iwao Y
    • Organizer
      Digestive Disease Week 2016
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aging, Smoking, Dyslipidemia, and Obesity Are Independently Associated With the Prevalence of Colorectal Neoplasia in Japan: Analyses of Comprehensive Health Checkup Data2015

    • Author(s)
      noue N, Takayama M, Makino K, Matsuzaki J, Shiomi E, Shimizu R, Yoshida T, Kashiwagi K, Hirose H, Momoshima S, Sugino Y, Iwao Y
    • Organizer
      Annual Scientific Meeting of the American College of Gastroenterology
    • Place of Presentation
      ハワイ(アメリカ)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A new, rapid, effective, tolerable, and safe preparation suitable for colonoscopy: a morning-only preparation using reduced-volume polyethylene glycol and electrolyte solution (peg-els) plus ascorbic acid2014

    • Author(s)
      Inoue N, Iwao Y, Matsuzaki J, Yoshida T, Shimizu R, Takayama M, Sugino Y
    • Organizer
      Asian Pacific Digestive Week 2014
    • Place of Presentation
      バリ(インドネシア)
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Research-status Report
  • [Presentation] MRエンテログラフィーによる生物学的製剤2次無効例に対するクローン病治療法の選択2014

    • Author(s)
      長沼誠、久松理一、松岡克善、井上詠、岩男泰、金井隆典、緒方晴彦
    • Organizer
      第69回日本大腸肛門病学会
    • Place of Presentation
      横浜ベイホテル東急・パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸カプセル内視鏡は潰瘍性大腸炎粘膜治癒の評価に有用か.2014

    • Author(s)
      三枝慶一郎、長沼誠、細江直樹、柏木和弘、新井万里、清原裕貴、森清人、竹下梢、南木康作、武下達矢、中里圭宏、松岡克善、久松理一、井上詠、岩男泰、緒方晴彦、金井隆典
    • Organizer
      第98回日本消化器内視鏡学会関東地方会
    • Place of Presentation
      シェーンバッハ・サボー(東京都千代田区)
    • Year and Date
      2014-06-14
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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