Prediction of treatment efficacy for severe ulcerative colitis

• Project/Area Number: 26460977
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: inoue nagamu 慶應義塾大学, 医学部(信濃町), 准教授 (00232546)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 潰瘍性大腸炎 / 炎症性腸疾患 / 治療 / 再燃 / 効果予測 / 内視鏡

Outline of Final Research Achievements

We explored the association of a variety of factors including endoscopic activity of patients in clinical remission with their long-term clinical outcome. Mayo endoscopic score 1 (hazard ratio (HR): 2.86) and score 2 (HR: 3.60) was significant risk factor for clinical relapse against endoscopic score 0. Univariate analysis also identified significant association with relapse for moderate clinical activity of last flare, remission induction with cytapheresis (CAP), maintenance with imuunomodulator, shorter duration of remission and higher histological activity. Cox regression analysis revealed that endoscopic activity, histological activity, duration of remission and remission induction with CAP were found to be independent determinants of relapse. The Kaplan-Meier estimate of non-relapse rate by endoscopic activity groups demonstrated significant difference. While there was significance between score 0 and 1, there were no significance between score 1 and 2.

Research Products

• [Journal Article] The Ulcerative Colitis Endoscopic Index of Severity is Useful to Predict Medium- to Long-Term Prognosis in Ulcerative Colitis Patients with Clinical Remission. (2016)
  • Author(s): Arai M, Naganuma M, Sugimoto S, Kiyohara H, Ono K, Mori K, Saigusa K, Nanki K, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hosoe N, Matsuoka K, Inoue N, Ogata H, Iwao Y, Kanai T
  • Journal Title: J Crohns Colitis 10 Volume: 10 Issue: 2 Pages: 1303-9
  • DOI: 10.1007/s00535-016-1209-x
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for decreased bone mineral density in inflammatory bowel disease: A cross-sectional study. (2015)
  • Author(s): Wada Y, Hisamatsu T, Naganuma M, Matsuoka K, Okamoto S, Inoue N, Yajima T, Kouyama K, Iwao Y, Ogata H, Hibi T, Abe T, Kanai T
  • Journal Title: Clin Nutr Volume: 34 Issue: 6 Pages: 1202-9
  • DOI: 10.1016/j.clnu.2015.01.003
  • Peer Reviewed / Open Access
• [Journal Article] Adalimumab for the treatment of Japanese patients with intestinal Behçet's disease. (2015)
  • Author(s): Tanida S, Inoue N, Kobayashi K, Naganuma M, Hirai F, Iizuka B, Watanabe K, Mitsuyama K, Inoue T, Ishigatsubo Y, Suzuki Y, Nagahori M, Motoya S, Nakamura S, Arora V, Robinson AM, Thakkar RB, Hibi T.
  • Journal Title: Clin Gastroenterol Hepatol Volume: 13 Issue: 5 Pages: 940-948
  • DOI: 10.1016/j.cgh.2014.08.042
  • Peer Reviewed
• [Journal Article] Risk and Management of Intra-Abdominal Abscess in Crohn's Disease Treated with Infliximab (2014)
  • Author(s): Yoneno K, Hisamatsu T, Matsuoka K, Okamoto S, Takayama T, Ichikawa R, Sujino T, Miyoshi J, Takabayashi K, Mikami Y, Mizuno S, Wada Y, Yajima T, Naganuma M, Inoue N, Iwao Y, Ogata H, Hasegawa H, Kitagawa Y, Hibi T, Kanai T
  • Journal Title: Digestion Volume: 89 Issue: 3 Pages: 201-208
  • DOI: 10.1159/000360618
  • Peer Reviewed / Open Access
• [Presentation] Aging, current smoking and metabolic factors are independently associated with the prevalence of colorectal neoplasia in Japan: analyses of comprehensive health checkup data (2016)
  • Author(s): Inoue N, Takayama M, Bessho R, Makino K, Shimizu-Hirota R, Yoshida T, Kashiwagi K, Yoshida T, Hirose H, Ogata H, Sugino Y, Iwao Y
  • Organizer: 24th United European Gastroenterology Week 2016
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] Metabolic factors in addition to aging and current smoking are independently associated with the prevalence of colorectal neoplasia in Japan: Analyses if comprehensive heath checkup data. (2016)
  • Author(s): Inoue N, Takayama M, Makino K, Shiomi E, Shimizu-Hirota R, Yoshida T, Kashiwagi K, Hirose H, Momoshima S, Sugino Y, Iwao Y
  • Organizer: Digestive Disease Week 2016
  • Place of Presentation: San Diego, CA
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] Aging, Smoking, Dyslipidemia, and Obesity Are Independently Associated With the Prevalence of Colorectal Neoplasia in Japan: Analyses of Comprehensive Health Checkup Data (2015)
  • Author(s): noue N, Takayama M, Makino K, Matsuzaki J, Shiomi E, Shimizu R, Yoshida T, Kashiwagi K, Hirose H, Momoshima S, Sugino Y, Iwao Y
  • Organizer: Annual Scientific Meeting of the American College of Gastroenterology
  • Place of Presentation: ハワイ(アメリカ)
  • Year and Date: 2015-10-16
  • Int'l Joint Research
• [Presentation] A new, rapid, effective, tolerable, and safe preparation suitable for colonoscopy: a morning-only preparation using reduced-volume polyethylene glycol and electrolyte solution (peg-els) plus ascorbic acid (2014)
  • Author(s): Inoue N, Iwao Y, Matsuzaki J, Yoshida T, Shimizu R, Takayama M, Sugino Y
  • Organizer: Asian Pacific Digestive Week 2014
  • Place of Presentation: バリ（インドネシア）
  • Year and Date: 2014-11-22 – 2014-11-25
• [Presentation] MRエンテログラフィーによる生物学的製剤2次無効例に対するクローン病治療法の選択 (2014)
  • Author(s): 長沼誠、久松理一、松岡克善、井上詠、岩男泰、金井隆典、緒方晴彦
  • Organizer: 第69回日本大腸肛門病学会
  • Place of Presentation: 横浜ベイホテル東急・パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-11-07
• [Presentation] 大腸カプセル内視鏡は潰瘍性大腸炎粘膜治癒の評価に有用か． (2014)
  • Author(s): 三枝慶一郎、長沼誠、細江直樹、柏木和弘、新井万里、清原裕貴、森清人、竹下梢、南木康作、武下達矢、中里圭宏、松岡克善、久松理一、井上詠、岩男泰、緒方晴彦、金井隆典
  • Organizer: 第98回日本消化器内視鏡学会関東地方会
  • Place of Presentation: シェーンバッハ・サボー（東京都千代田区）
  • Year and Date: 2014-06-14