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MICA expression regulation by small nucleic acids to prevent HCC occurrence

Research Project

Project/Area Number 26460984
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

Sato Masaya  東京大学, 医学部附属病院, 特任臨床医 (30722665)

Co-Investigator(Kenkyū-buntansha) 大塚 基之  東京大学, 医学部附属病院, 助教 (90518945)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsMICA / 免疫療法 / 肝癌 / 自然免疫 / 癌 / NKG2D / NK細胞 / 核酸
Outline of Final Research Achievements

The investigators identified MICA gene as a susceptible gene to hepatocellular carcinoma by GWAS analyses using 1,394 HCV-related patients and 5,486 non-infected patients. In this study, MICA expression could be regulated by microRNA25-106b. Further, using CRISPR-Cas9 and Cas9-VP16 fusion construct, trascription of MICA mRNA could be augmented about te times. These results may lead to the regulation of MICA gene expression, which in turn result in the prevention of hepatocellular carcinoma occurrence.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Remarks (1 results)

  • [Int'l Joint Research] Icahn School of Medicine at Mount Sinai(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Transcriptional activation of the MICA gene with an engineered CRISPR-Cas9 system2017

    • Author(s)
      Sekiba K, Yamagami M, Otsuka M, Suzuki T, Kishikawa T, Ishibashi R, Ohno M, Sato M, Koike K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: - Issue: 2 Pages: 521-525

    • DOI

      10.1016/j.bbrc.2017.03.076

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of a screening method to identify regulators of MICA shedding.2015

    • Author(s)
      Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Sato M, Koike K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 465 Issue: 4 Pages: 764-768

    • DOI

      10.1016/j.bbrc.2015.08.081

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ecreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.2015

    • Author(s)
      Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 8339-8352

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA.2014

    • Author(s)
      Ohno M, Otsuka M, Kishikawa T, Shibata C, Yoshikawa T, Takata A, Muroyama R, Kowatari N, Sato M, Kato N, Kuroda S, Koike K
    • Journal Title

      Oncotarget

      Volume: 5 Pages: 5581-90

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects.2014

    • Author(s)
      Otsuka M, Kishikawa T, Yoshikawa T, Ohno M, Takata A, Shibata C, Koike K.
    • Journal Title

      J Gastroenterol.

      Volume: 49 Issue: 2 Pages: 173-84

    • DOI

      10.1007/s00535-013-0909-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Remarks] 研究グループホームページ

    • URL

      https://sites.google.com/site/225kenncrna/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-01-27  

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