Regulation of liver cancer stem cells by cirrhotic liver microenvironment
| Project/Area Number |
26460994
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肝細胞癌 / 癌幹細胞 / 肝硬変 / 微小環境 / がん幹細胞 / がん微小環境 / エピジェネテッィク制御 / サイトカイン / 抗がん剤感受性 / 肝がん幹細胞 / 可塑性 / エピジェネティック変化 |
|---|
| Outline of Final Research Achievements |
Recent evidences suggest that hepatocellular carcinoma possesses cancer stem cells that play a pivotal role on local recurrence and distant organ metastasis after radical treatment. In this study, we found that fibroblasts secrets TGF-beta and induce the stemness in EpCAM+ hepatocellular carcinoma. This effect was mediated at least in part through the activation of H3K36 demethylase KDM2B to modify epigenetic memories and induce the population of EpCAM+ cancer stem cells. We further identified the six cytokines, potentially reflecting the activation of microenvironment of hepatocellular carcinoma, to predict the survival outcome of hepatocellular carcinoma patients who received sorafenib treatment.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] De Novo Emergence of Mesenchymal Stem-Like CD105+ Cancer Cells by Cytotoxic Agents in Human Hepatocellular Carcinoma.2017
Author(s)
Nomura Y, Yamashita T, Oishi N, Nio K, Hayashi T, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Okada H, Sunagozaka H, Takatori H, Honda M, Kaneko S.
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Journal Title
Transl Oncol.
Volume: -
Issue: 2
Pages: 184-189
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Defeating EpCAM(+) liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma.2015
Author(s)
Nio K, Yamashita T, Okada H, Kondo M, Hayashi T, Hara Y, Nomura Y, Zeng SS, Yoshida M, Hayashi T, Sunagozaka H, Oishi N, Honda M, Kaneko S
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Journal Title
J. Hepatology
Volume: 5
Issue: 5
Pages: 1164-72
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma.2014
Author(s)
Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, Kaneko S
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Journal Title
Hepatology
Volume: in press
Issue: 5
Pages: 1674-85
DOI
Related Report
Peer Reviewed / Open Access
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