Whole-exome sequencing identifies a novel genetic susceptibility locus in autoimmune liver diseases
| Project/Area Number |
26460996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shinshu University |
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Principal Investigator |
UMEMURA Takeji 信州大学, 学術研究院医学系, 准教授 (30419345)
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| Co-Investigator(Renkei-kenkyūsha) |
OTA Masao 信州大学, 学術研究院医学系, 准教授 (50115333)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | AIH / PBC / HLA / PTPN22 / sCD14 / IL-8 / M2BP / 細胞死 |
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| Outline of Final Research Achievements |
The key findings in this study were: (1) HLA, PTPN22, and PRKCB genes are significantly associated with susceptibility and resistance to autoimmune liver diseases (autoimmune hepatitis and primary biliary cholangitis) in Japan; (2) Serum Mac-2-binding protein, cell death, soluble CD14, and IL-8 levels were simple, and reliable noninvasive surrogate marker of liver fibrosis and prognosis in patients with primary biliary cholangitis.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Association between serum soluble CD14 and IL-8 levels and clinical outcome in primary biliary cholangitis2017
Author(s)
Umemura, T. Sekiguchi, T. Joshita, S. Yamazaki, T. Fujimori, N. Shibata, S. Ichikawa, Y. Komatsu, M. Matsumoto, A. Shums, Z. Norman, G. L. Tanaka, E. Ota, M.
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Journal Title
Liver International
Volume: 印刷中
Issue: 6
Pages: 897-905
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Serum Cell Death Biomarkers for Prediction of Liver Fibrosis and Poor Prognosis in Primary Biliary Cirrhosis2015
Author(s)
Sekiguchi T, Umemura T, Fujimori N, Ichikawa Y, Shibata S, Kimura T, Joshita S, Komatsu M, Matsumoto A, Tanaka E, Ota M
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Journal Title
PLOS ONE
Volume: 10
Issue: 6
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis.2014
Author(s)
Joshita S, Umemura T, Nakamura M, Katsuyama Y, Shibata S, Kimura T, Morita S, Komatsu M, Matsumoto A, Yoshizawa K, Ishibashi H, Tanaka E, Ota M.
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Journal Title
Disease Markers
Volume: Epub
Pages: 727393-727393
DOI
NAID
Related Report
Peer Reviewed / Open Access
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