Analysis of pathogenesis of nonalcoholic fatty liver disease from recurrent disease after liver transplantation

• Project/Area Number: 26461000
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: Ueda Yoshihide 京都大学, 医学研究科, 特定講師 (90378662)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 非アルコール性脂肪性肝疾患 / 脂肪肝 / 脂肪肝炎 / 肝移植 / 肝細胞癌 / 膵切除

Outline of Final Research Achievements

1. Recurrence of NAFLD after liver transplantation: Rate of occurrence of fatty liver and NASH after liver transplantation for cryptogenic cirrhosis were 69% and 41%, respectively. No significant risk factor for the occurrence was identified.
2. NAFLD after pancreatectomy: High degree of fatty liver occurred in 43 of 423 patients (10.2%) after pancreatectomy. Risk factors for the fatty liver were pancreatic cancer, and total pancreatectomy or pancreatoduodenectomy.
3. Genetic analysis of hepatocellular carcinoma in patients with NAFLD: TERT promoter mutations and 8p loss were identified as characteristic genetic change in hepatocellular carcinoma in patients with NAFLD.

Research Products

• [Journal Article] TERT promoter mutations and chromosome 8p loss are characteristic of nonalcoholic fatty liver disease-related hepatocellular carcinoma. (2016)
  • Author(s): Ki Kim S, Ueda Y, Hatano E, Kakiuchi N, Takeda H, Goto T, Shimizu T, Yoshida K, Ikura Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Uemoto S, Chiba T, Ogawa S, Marusawa H.
  • Journal Title: Int J Cancer. Volume: 139 Issue: 11 Pages: 2512-2518
  • DOI: 10.1002/ijc.30379
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant