| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In the process of cancer initiation and development, escape from tumor immunosurveillance has been thought to be important. However its molecular mechanisms are still unclear. This study aimed to clarify regulatory mechanisms of the expression of immune target molecules induced by viral infection of human non-cancer hepatocytes by utilizing iPS cell technologies and establish a system for drug discovery targeting it.
In this study, we established a drug-inducible system for forced expression of each proteins encoded by hepatitis C virus in human iPS cell - derived hepatocytes. Using this system, we analyzed the regulatory mechanism of the expression of immune target molecules.
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