| Project/Area Number |
26461006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Okayama University |
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Principal Investigator |
Takaki Akinobu 岡山大学, 医歯薬学総合研究科, 准教授 (80359885)
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| Co-Investigator(Kenkyū-buntansha) |
太田 成男 日本医科大学, 大学院医学研究科, 大学院教授 (00125832)
渡辺 信和 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 細胞治療科医長 (10334278)
恩地 正浩 岡山大学, 医学部, 客員研究員 (20727391)
松下 浩志 岡山大学, 医学部, 客員研究員 (20786107)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肝癌 / 非アルコール性脂肪性肝炎 / 胆管癌 / 酸化ストレス / 抗酸化薬 / 胆管細胞癌 / 脂肪肝 / 肝細胞癌 |
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| Outline of Final Research Achievements |
Oxidative stress is associated with the progression of chronic liver disease. Non-alcoholic steatohepatitis (NASH) is an oxidative stress-related disease. However, the oxidative / anti-oxidative balance has so far not been fully characterized in NASH. The objective of the present study was to investigate the oxidative stress and the anti-oxidative activity in NASH, including concomitant hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCC). NASH-HCC patients exhibited a lower OXY than NASH. In mice, vitamin E administration induced antioxidant hemeoxygenase (HO)-1 protein expression in CCC cancer tissue, while the number of stem-like cells increased. L-Carnitine administration improved intestinal microbiome and biliary acid balance, upregulated the hepatic mitochondrial membrane uptake related gene in non-cancerous tissue, and did not alter stem-like cell numbers. The mitochondrial function-supporting agent L-carnitine is a good candidate to control oxidative stress conditions.
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