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Enhancement of the effect of hepatic arterial infusion chemotherapy by introducing microRNA

Research Project

Project/Area Number 26461007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionOkayama University

Principal Investigator

Nakamura Shinichiro  岡山大学, 大学病院, 助教 (70514230)

Co-Investigator(Kenkyū-buntansha) 能祖 一裕  岡山大学, 医学部, 客員研究員 (10314668)
大西 秀樹  岡山大学, 大学病院, 助教 (30595468)
白羽 英則  岡山大学, 大学病院, 講師 (40379748)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsmiRNA / 肝細胞癌 / シスプラチン感受性 / テロメスキャン
Outline of Final Research Achievements

Cisplatin is widely used for the therapy of hepatocellular carcinoma. However, the response rate of cisplatin is not high. In this study, we tried to enhance the effect of cisplatin by introducing microRNA that had been reported to correlate with cisplatin resistance into cancer cells. The effect of forty-one candidate micro RNA was examined. Among various combinations of micro RNA, cocktail of 7 micro RNA and cisplatin could effectively suppress the growth of hepatocellular carcinoma cels.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] マイクロRNA阻害による肝癌化学療法治療効果増強の試み2016

    • Author(s)
      森元裕貴,能祖一裕,大山淳史,赤穂宗一郎,和田望, 土肥千紘,竹内康人,安中幸,安中哲也,桑木健志,大西秀樹,池田房雄,中村進一郎,白羽英則, 高木章乃夫,岡田裕之
    • Organizer
      肝癌分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-01-16
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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