Analysis of participation of miRNAs to lipid metabolic malfunction by hepatitis C virus
| Project/Area Number |
26461014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
SAITO SATORU 横浜市立大学, 医学部, 准教授 (00275041)
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| Co-Investigator(Kenkyū-buntansha) |
中島 淳 横浜市立大学, 医学研究科, 教授 (30326037)
今城 健人 横浜市立大学, 附属病院, 助教 (30600192)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ウイルス / 肝炎 / microRNA / C型肝炎 / miRNAs / 脂質 |
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| Outline of Final Research Achievements |
There are many reports so far for using host’s lipid metabolism for a hepatitis C virus (below HCV) and making the environment of the replication and infection profitable. It was considered whether the anti-viral effect could be expected by miRNA-33, which participates in lipid metabolism, restraining replication and infection of an HCV, but the effect wasn't indicated. On the other hand, the expression of miRNA-27 was accelerated in the liver of non-alcoholic steatohepatitis hepatitis (NASH) patients. This miRNA-27 can be a marker of improvement for fibrosis in HCV patients after treatment.
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Report
(4 results)
Research Products
(7 results)
