Significance of HBV integration during hepatocarcinogenesis

• Project/Area Number: 26461016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Minami Masahito 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (60326220)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: B型肝炎ウイルス / 肝発癌 / 肝癌 / integration

Outline of Final Research Achievements

We have demonstrated that (1) integrated HBV genomes are often located near host genomes associated with cell growth, (2) integrated HBV genomes are frequently seen in the common fragile sites that are preferentially transcripted and translated during cell cycles, and (3) some HBV-integrated genes like hTERT are found in different cases as common integration sites. These findings suggest that HBV integration is not a random event and that it can give positive effects for affected host cells to survive and proliferate during chronic inflammation state.

Research Products

• [Journal Article] Liver stiffness measurement to platelet ratio index predicts the stage of liver fibrosis in non-alcoholic fatty liver disease. (2017)
  • Author(s): Okajima A, Sumida Y, Taketani H, Hara T, Seko Y, Ishiba H, Nishimura T, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Mitsuyoshi H, Ysui K, Minami M, Itoh Y.
  • Journal Title: Hepatology Research Volume: 47(8) Issue: 8 Pages: 721-730
  • DOI: 10.1111/hepr.12793
  • Peer Reviewed
• [Journal Article] Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of non-alcoholic fatty liver disease. (2017)
  • Author(s): Mitsuyoshi H, Yasui K, Hara T, Taketani H, Ishiba H, Okajima A, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Minami M, Itoh Y.
  • Journal Title: Hepatol Res Volume: - Issue: 13 Pages: 1459-1468
  • DOI: 10.1111/hepr.12883
  • Peer Reviewed
• [Journal Article] Future therapy for hepatitis B virus infection. (2015)
  • Author(s): Minami M
  • Journal Title: Clin J Gastroenterol Volume: 8 Issue: 4 Pages: 167-171
  • DOI: 10.1007/s12328-015-0590-y
  • Peer Reviewed / Open Access
• [Journal Article] HBVゲノムのインテグレーション (2015)
  • Author(s): 南 祐仁
  • Journal Title: 日本臨牀 Volume: 73(9) Pages: 409-413
• [Journal Article] Efficacy and safety of sorafenib in very elderly patients aged 80 years and older with advanced hepatocellular carcinoma (2014)
  • Author(s): Jo M, Yasui K, Kirishima T, Shima T, Niimi T, Katayama T, Mori T, Funaki J, Sumida Y, Fujii H, Takami S, Kimura H, Mitsumoto Y, Minami M, Yamaguchi K, Yoshinami N, Mizuno M, Sendo R, Tanaka S, Shintani H, Kagawa K, Okanoue T, Itoh Y
  • Journal Title: Hepatol Res Volume: (Epub ahead of print) Issue: 13 Pages: 1329-38
  • DOI: 10.1111/hepr.12308
  • Peer Reviewed