Pancreatic congestion in liver cirrhosis correlates with impaired insulin secretion

• Project/Area Number: 26461034
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: Kumagi Teru 愛媛大学, 医学系研究科, 寄附講座准教授 (30594147)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肝硬変 / 門脈圧亢進症 / 膵血流 / 膵内分泌異常 / 膵外分泌異常

Outline of Final Research Achievements

Although impaired glucose tolerance is common in cirrhosis, pathogenesis of this condition remains undefined. This study aimed to clarify pathogenesis related to the pancreas in cirrhotic patients, and to evaluate associations between insulin secretion and pancreatic congestion. Pancreatic perfusion parameters were analyzed by dynamic contrast-enhanced ultrasound (CE-US) in cirrhotic and non-cirrhotic patients and prospectively compared to ΔCPR; a parameter for secretion of insulin. CE-US study showed that pancreatic drainage times were greater in the cirrhotic group, and had a significant negative correlation with ΔCPR. In conclusion, pancreatic congestion was present in cirrhotic patients. Moreover, pancreatic congestion and insulin secretion were significantly correlated. This pathogenesis could be a key factor underlying the development of hepatogenous diabetes in cirrhotic patients.

Research Products

• [Journal Article] Comparison between real-time tissue elastography and vibration-controlled transient elastography for the assessment of liver fibrosis and disease progression in patients with primary biliary cholangitis. (2017)
  • Author(s): Koizumi Y, Hirooka M, Abe M, Tokumoto Y, Yoshida O, Watanabe T, Nakamura Y, Imai Y, Yukimoto A, Kumagi T, Takeshita E, Ikeda Y, Hiasa Y.
  • Journal Title: Hepatol Res Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Efficacy of chemotherapy in elderly patients with unresectable pancreatic cancer: a multicenter review of 895 patients (2017)
  • Author(s): Kuroda T, Kumagi T, Yokota T, Azemoto N, Hasebe A, Seike H, Nishiyama M, Inada N, Shibata N, Miyata H, Kawamura T, Imai Y, Ueno-Toshimori A, Tanaka Y, Terao T, Imamura Y, Koizumi M, Yamanishi H, Ohno Y, Hiasa Y, on behalf of the Ehime Pancreato-Cholangiology (EPOCH) Study Group
  • Journal Title: BMC Gastroenterol Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Differences in the risk of fatty liver for onset of impaired fasting glucose according to baseline plasma glucose levels (2017)
  • Author(s): Miyake T, Hirooka M, Yoshida O, Furukawa S, Kumagi T, Koizumi M, Yamamoto S, Kuroda T, Arimitsu E, Takeshita E, Abe M, Kitai K, Matsuura B, Hiasa Y
  • Journal Title: J Gastroenterol Volume: 52 Issue: 2 Pages: 237-244
  • DOI: 10.1007/s00535-016-1234-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early pancreatic volume reduction on CT predicts relapse in patients with type 1 autoimmune pancreatitis treated with steroids. (2016)
  • Author(s): Ohno Y, Kumagi T, Yokota T, Azemoto N, Tanaka Y, Tange K, Inada N, Miyata H, Imamura Y, Koizumi M, Kuroda T, Hiasa Y; EPOCH Study Group.
  • Journal Title: Orphanet J Rare Dis Volume: 11 Issue: 1 Pages: 103-110
  • DOI: 10.1186/s13023-016-0487-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women. (2016)
  • Author(s): Kawamoto R, Katoh T, Ninomiya D, Kumagi T, Abe M, Kohara K.
  • Journal Title: Endocr Res Volume: 41 Issue: 2 Pages: 116-123
  • DOI: 10.3109/07435800.2015.1094085
  • Peer Reviewed
• [Journal Article] Difficulty in management of intraductal papillary mucinous neoplasm-associated pancreatobiliary fistulas and the role of "pig-nose" appearance and intraductal ultrasonography in diagnosis. (2016)
  • Author(s): Koizumi M, Kumagi T, Kuroda T, Azemoto N, Yamanishi H, Ohno Y, Yokota T, Ochi H, Tange K, Ikeda Y, Hiasa Y.
  • Journal Title: Endosc Int Open Volume: 4 Issue: 04 Pages: E446-E450
  • DOI: 10.1055/s-0042-102956
  • Peer Reviewed / Open Access
• [Journal Article] Low alcohol consumption increases the risk of impaired glucose tolerance in patients with non-alcoholic fatty liver disease. (2016)
  • Author(s): Teruki Miyake
  • Journal Title: Journal of Gastroenterology Volume: 印刷中 Issue: 11 Pages: 1090-1100
  • DOI: 10.1007/s00535-016-1194-0
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study. (2016)
  • Author(s): Trivedi PJ, Lammers WJ, van Buuren HR, Pares A, Floreani A, Janssen HL, Invernizzi P, Battezzati PM, Ponsioen CY, Corpechot C, Poupon R, Mayo MJ, Burroughs AK, Nevens F, Mason AL, Kowdley KV, Lleo A, Caballeria L, Lindor KD, Kumagi T, et al.
  • Journal Title: Gut Volume: 65 Issue: 2 Pages: 321-329
  • DOI: 10.1136/gutjnl-2014-308351
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Utility of contrast-enhanced transabdominal ultrasonography to diagnose early chronic pancreatitis. (2015)
  • Author(s): Azemoto N, Kumagi T, Yokota T, Hirooka M, Kuroda T, Koizumi M, Ohno Y, Yamanishi H, Abe M, Hiasa Y, Onji M.
  • Journal Title: BioMed Res Int 2015; 2015: 393124. Volume: 2015 Pages: 393124-393124
  • DOI: 10.1155/2015/393124
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study. (2015)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Furukawa S, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Nunoi H, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: 50 Issue: 2 Pages: 230-237
  • DOI: 10.1007/s00535-014-0959-6
  • Peer Reviewed / Open Access
• [Journal Article] Quantification of pancreas stiffness on intraoperative ultrasound elastography and evaluation of its relationship with postoperative pancreatic fistula. (2015)
  • Author(s): Hatano M, Watanabe J, Kushihata F, Tohyama T, Kuroda T, Koizumi M, Kumagi T, Hisano Y, Sugita A, Takada Y.
  • Journal Title: Int Surg 2015: 100; 497-502. Volume: 100 Issue: 3 Pages: 497-502
  • DOI: 10.9738/intsurg-d-14-00040.1
  • Peer Reviewed / Open Access
• [Journal Article] An unusual case of abdominal pain. (2015)
  • Author(s): Koizumi M, Kumagi T, Hiasa Y.
  • Journal Title: Gastroenterology. 2015 Apr;148(4):e1-2. Volume: 148 Issue: 4 Pages: e1-e2
  • DOI: 10.1053/j.gastro.2014.10.057
  • Peer Reviewed
• [Journal Article] Development and Validation of a Scoring System to Predict Outcomes of Patients With Primary Biliary Cirrhosis Receiving Ursodeoxycholic Acid Therapy. (2015)
  • Author(s): Lammers WJ, Hirschfield GM, Corpechot C, Nevens F, Lindor KD, Janssen HL, Floreani A, Ponsioen CY, Mayo MJ, Invernizzi P, Battezzati PM, Parés A, Burroughs AK, Mason AL, Kowdley KV, Kumagi T, Harms MH, Trivedi PJ, Poupon R, Cheung A, Lleo A, Caballeria L, Hansen BE, van Buuren HR; Global PBC Study Group.
  • Journal Title: Gastroenterology 2015; 149: 1804-1812. Volume: 149 Issue: 7 Pages: 1804-1812
  • DOI: 10.1053/j.gastro.2015.07.061
  • Peer Reviewed
• [Journal Article] A case of hepatocellular carcinoma treated by radiofrequency ablation confirming the adjacent major bile duct under hybrid contrast mode through a biliary drainage catheter. (2015)
  • Author(s): Imai Y, Hirooka M, Ochi H, Koizumi Y, Ohno Y, Watanabe T, Tokumoto Y, Kumagi T, Abe M, Hiasa Y.
  • Journal Title: Clin J Gastroenterol 2015; 8: 318-322. Volume: 8 Issue: 5 Pages: 318-322
  • DOI: 10.1007/s12328-015-0599-2
  • Peer Reviewed
• [Journal Article] Drug-induced Liver Injury with Serious Multiform Exudative Erythema following the Use of an Over-the-counter Medication Containing Ibuprofen (2015)
  • Author(s): Watanabe T, Abe M, Tada F, Aritomo K, Ochi H, Koizumi Y, Tokumoto Y, Hirooka M, Kumagi T, Ikeda Y, Matsuura B, Hiasa Y.
  • Journal Title: Internal Medicine Volume: 54 Issue: 4 Pages: 395-399
  • DOI: 10.2169/internalmedicine.54.3204
  • NAID: 130004903044
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Brachial-ankle pulse wave velocity is a predictor of walking distance in community-dwelling adults. (2015)
  • Author(s): Kawamoto R, Kohara K, Katoh T, Kusunoki T, Ohtsuka N, Abe M, Kumagi T, Miki T.
  • Journal Title: Aging Clin Exp Res 2015: 27; 187-193. Volume: 27 Issue: 2 Pages: 187-193
  • DOI: 10.1007/s40520-014-0262-7
  • Peer Reviewed
• [Journal Article] Changes in oxidized low-density lipoprotein cholesterol are associated with changes in handgrip strength in Japanese community-dwelling persons. (2015)
  • Author(s): Kawamoto R, Kohara K, Katoh T, Kusunoki T, Ohtsuka N, Abe M, Kumagi T, Miki T.
  • Journal Title: Endocrine 2015: 48; 871-877. Volume: 48 Issue: 3 Pages: 871-877
  • DOI: 10.1007/s12020-014-0360-5
  • Peer Reviewed
• [Journal Article] Characteristics of Japanese medical students associated with their intention for rural practice. (2015)
  • Author(s): Kawamoto R, Uemoto A, Ninomiya D, Hasegawa Y, Ohtsuka N, Kusunoki T, Kumagi T, Abe M.
  • Journal Title: Rural Remote Health. 2015; 15: 3112. Volume: 15 Pages: 3112-3112
  • Peer Reviewed / Open Access
• [Journal Article] Pancreatic congestion in liver cirrhosis correlates with impaired insulin secretion. (2014)
  • Author(s): Kuroda T, Hirooka M, Koizumi M, Ochi H, Hisano Y, Bando K, Matsuura B, Kumagi T, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: Epub Issue: 6 Pages: 583-9
  • DOI: 10.1007/s00535-014-1001-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Short sleep duration reduces the risk of nonalcoholic fatty liver disease onset in men: a community-based longitudinal cohort study. (2014)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: Epub Issue: 5 Pages: 583-9
  • DOI: 10.1007/s00535-014-0989-0
  • Peer Reviewed / Open Access
• [Journal Article] Levels of alkaline phosphatase and bilirubin values are surrogate endpoints of outcome for patients with primary biliary cirrhosis; an international follow-up study. (2014)
  • Author(s): Lammers WJ, van Buuren HR, Hirschfield GM, Janssen HLA, Invernizzi P, Mason AL, Talwalkar J, Ponsioen CY, Floreani A, Corpechot C, Mayo MJ, Battezzati PM, Parés A, Nevens F, Burroughs AK, Kowdley KV, Trivedi PJ, Kumagi T, et al. ; on behalf of the Global PBC Study Group.
  • Journal Title: Gastroenterology Volume: 147 Pages: 1338-1349
  • Peer Reviewed
• [Journal Article] Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study. (2014)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed / Open Access
• [Journal Article] Mildly Elevated Serum Bilirubin Levels Are Negatively Associated with Carotid Atherosclerosis among Elderly Persons. (2014)
  • Author(s): Kawamoto R, Ninomiya D, Hasegawa Y, Kasai Y, Kusunoki T, Ohtsuka N, Kumagi T, Abe M.
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed / Open Access
• [Journal Article] Effect of weight loss on central systolic blood pressure in elderly community-dwelling persons. (2014)
  • Author(s): Kawamoto R, Kohara K, Katoh T, Kusunoki T, Ohtsuka N, Abe M, Kumagi T, Miki T.
  • Journal Title: Hypertens Res Volume: 37 Pages: 933-938
  • Peer Reviewed
• [Journal Article] Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus. (2014)
  • Author(s): Furukawa S, Yamamoto S, Maruyama K, Miyake T, Ueda T, Niiya T, Takatoshi S, Torisu M, Kumagi T, Sakai T, Minami H, Miyaoka H, Matsuura B, Hiasa Y, Onji M, Tanigawa T.
  • Journal Title: Endocrine J Volume: 61 Pages: 1011-1018
  • NAID: 130004677945
  • Peer Reviewed / Open Access
• [Journal Article] An HBV-HIV co-infected patient treated with tenofovir-based therapy who achieved HBs antigen/antibody seroconversion. (2014)
  • Author(s): Watanabe T, Tokumoto Y, Hirooka M, Koizumi Y, Tada F, Ochi H, Abe M, Kumagi T, Ikeda Y, Matsuura B, Takada K, Hiasa Y.
  • Journal Title: Intern Med Volume: 53 Pages: 1343-1346
  • NAID: 130004466367
  • Peer Reviewed / Open Access
• [Journal Article] Signet-ring cell carcinoma of the gallbladder complicated with pulmonary tumor thrombotic microangiopathy. (2014)
  • Author(s): Ohno Y, Kumagi T, Kuroda T, Koizumi M, Azemoto N, Yamanishi H, Oda M, Hirooka M, Abe M, Ikeda Y, Matsuura B, Onji M, Soga Y, Mizuno Y, Sugita A, Hiasa Y.
  • Journal Title: Intern Med Volume: 53 Pages: 1125-1129
  • Peer Reviewed / Open Access
• [Journal Article] Good maternal and fetal outcomes in pregnancy associated with primary biliary cirrhosis. (2014)
  • Author(s): Trivedi P, Kumagi T, Al-Harthy N, Coltescu C, Ward S, Cheung AC, Hirschfield GM.
  • Journal Title: Clin Gastroenterol Hepatol Volume: 12 Pages: 1179-1185
  • Peer Reviewed
• [Journal Article] Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response. (2014)
  • Author(s): Trivedi P, Bruns T, Cheung AC, Li KK, Kumagi T, Shah H, Corbett C, Al-Harthy N, Acarsu U, Coltescu C, Tripathi D, Neuberger J, Janssen H, Hirschfield GM.
  • Journal Title: J Hepatol Volume: 60 Pages: 1249-1258
  • Peer Reviewed
• [Journal Article] Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation. (2014)
  • Author(s): Hirooka M, Ochi H, Koizumi Y, Tokumoto Y, Hiraoka A, Kumagi T, Abe M, Tanaka H, Hiasa Y.
  • Journal Title: Mol Clin Oncol Volume: 2 Pages: 182-186
  • Peer Reviewed / Open Access
• [Journal Article] Association between Serum Bilirubin and Estimated Glomerular Filtration Rate among Elderly Persons. (2014)
  • Author(s): Kawamoto R, Ninomiya D, Hasegawa Y, Kasai Y, Kusunoki T, Ohtsuka N, Kumagi T.
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed / Open Access