Research Project
Grant-in-Aid for Scientific Research (C)
We screened compounds that promote cell proliferation of mouse pancreatic β cells using 3,000 low molecular weight compounds. As a result, Domperidon (DPD) which is an antagonist of dopamine D2 receptor (Drd2) was identified. And it was also revealed that DPD has a strong dedifferentiation suppressing effect and cell death suppressing effect in addition to an increase of self-replicating ability of β cell.Furthermore, the formation of a heterodimer between Drd 2 and the adenosine A 2a receptoris important to control cell differentiation, dedifferentiation, cell division and cell death (Sakano et al., Stem Cell R eports, 2015).
All 2016 2015 2014 2013 Other
All Journal Article (5 results) (of which Peer Reviewed: 5 results, Open Access: 3 results, Acknowledgement Compliant: 4 results) Presentation (6 results) (of which Int'l Joint Research: 1 results, Invited: 1 results) Book (4 results) Remarks (3 results)
Stem Cell Reports
Volume: 7 Issue: 1 Pages: 95-109
10.1016/j.stemcr.2016.05.015
Methods Mol Biol.
Volume: 1341 Pages: 417-423
10.1007/7651_2015_217
Plos one
Volume: 9(4) Issue: 4 Pages: e95451-e95451
10.1371/journal.pone.0095451
Journal of Molecular Cell Biology
Volume: 6 Issue: 5 Pages: 394-408
10.1093/jmcb/mju029
Nat. Chem. Biol.
Volume: 10 Issue: 2 Pages: 141-148
10.1038/nchembio.1410
http://educ.titech.ac.jp/bio/news/2016_07/052422.html
http://kumanichi.com/news/local/main/20131216002.shtml
http://first.lifesciencedb.jp/archives/8151