| Project/Area Number |
26461038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
内田 一茂 関西医科大学, 医学部, 講師 (40411516)
西尾 彰功 関西医科大学, 医学部, 准教授 (50362463)
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| Co-Investigator(Renkei-kenkyūsha) |
UCHIDA Kazusige 関西医科大学, 医学部, 講師 (40411516)
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| Research Collaborator |
IKEURA Tsukasa
MITSUYAMA Toshiyuki
KATO Kota
FUKUHARA Takataro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 自己免疫性膵炎 / IgG4関連疾患 / 自然免疫 / アレルギー / TLR |
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| Outline of Final Research Achievements |
We investigated the role of basophils in type 1 AIP via stimulation of Toll-like receptors (TLR). The ratio of basophils activated with TLR4 stimulation in type1 AIP (9.87 5% ± 1.148) and atopic dermatitis (11.768 % ± 1.899) were significantly higher than in healthy subjects (5.051 % ± 0.730) (p<0.05). Levels of basophils activated with TLR2 stimulation were clearly increased in seven cases of type 1 AIP. In the immunohistochemistry experiments, basophils were detected in the pancreatic tissue of type 1 AIP patients in 10 of 13 cases (76.9 %). Furthermore, basophils expressed the same TLR in peripheral blood and tissue in five cases of type 1 AIP (TLR2 in two cases, TLR4 in 2 cases, and TLR2 and TLR4 in one case). In conclusion,
The basophils activated via TLR signaling may play an important role in the pathophysiology of type 1 AIP.
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