Identification of new nerve-delivered growth factor regarding pancreatic B cells
| Project/Area Number |
26461042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Okayama University of Science (2017)
Tohoku Medical and Pharmaceutical University (2014-2016) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 膵B細胞 / 神経因子 / 再生 / 増殖 / 膵Ｂ細胞 / 膵臓B細胞 / 膵臓Ｂ細胞 |
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| Outline of Final Research Achievements |
We found that vagal hyperactivity produced by ventromedial hypothalamic lesions stimulated cell proliferation of rat pancreatic islet B. Previously, we developed a new technique regarding high-quality RNA extraction from rat pancreas for cDNA microarray analysis. Results of cDNA microarray pick up several genes regarding new nerve-delivered growth factor of pancreatic B cells. Now, we conduct a mammalian vectors carrying the nerve-delivered genes, which are detected by microarray analysis. We believe that these new gene network analysis will lead to Pancreatic cancer and Diabetes Mellitus Treatment.
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Report
(5 results)
Research Products
(6 results)
