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Identification of new nerve-delivered growth factor regarding pancreatic B cells

Research Project

Project/Area Number 26461042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionOkayama University of Science (2017)
Tohoku Medical and Pharmaceutical University (2014-2016)

Principal Investigator

Kiba Takayoshi  岡山理科大学, 理学部, 教授 (80285139)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords膵B細胞 / 神経因子 / 再生 / 増殖 / 膵B細胞 / 膵臓B細胞 / 膵臓B細胞
Outline of Final Research Achievements

We found that vagal hyperactivity produced by ventromedial hypothalamic lesions stimulated cell proliferation of rat pancreatic islet B. Previously, we developed a new technique regarding high-quality RNA extraction from rat pancreas for cDNA microarray analysis. Results of cDNA microarray pick up several genes regarding new nerve-delivered growth factor of pancreatic B cells. Now, we conduct a mammalian vectors carrying the nerve-delivered genes, which are detected by microarray analysis. We believe that these new gene network analysis will lead to Pancreatic cancer and Diabetes Mellitus Treatment.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 5 results)

  • [Journal Article] Gene Expression Analysis in Rat Pancreas Observed with Whole-Transcript Exon Array after Ventromedial Hypothalamic Lesions2017

    • Author(s)
      Kiba Takayoshi
    • Journal Title

      Annals of Neurosciences

      Volume: 24 Issue: 1 Pages: 26-31

    • DOI

      10.1159/000464420

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ventromedial hypothalamic lesions downregulate multiple immune signaling pathways in rat pancreatic islets.2016

    • Author(s)
      Kiba T.
    • Journal Title

      Neurosci Lett.

      Volume: 610 Pages: 177-81

    • DOI

      10.1016/j.neulet.2015.11.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ventromedial Hypothalamic Lesions Down-Regulate the Expression of Adora1 Gene in Rat Pancreatic Islets.2016

    • Author(s)
      Kiba T, Ishigaki Y.
    • Journal Title

      Pancreas.

      Volume: 45

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Changes of the expressions of multiple metabolism genes in rat pancreatic islets after ventromedial hypothalamic lesioning.2015

    • Author(s)
      Kiba T.
    • Journal Title

      Neurosci Lett.

      Volume: 604 Pages: 64-8

    • DOI

      10.1016/j.neulet.2015.08.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ventromedial hypothalamic lesions downregulate the expression of Adora1 gene in rat pancreatic islets.2015

    • Author(s)
      Kiba T, Ishigaki Y.
    • Journal Title

      Pancreas

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ventromedial hypothalamic lesions change the expression of cell proliferation-related genes and morphology-related genes in rat pancreatic islets.2014

    • Author(s)
      Kiba T, Ishigaki Y.
    • Journal Title

      Islets

      Volume: 6 Issue: 5-6 Pages: e1012950-e1012950

    • DOI

      10.1080/19382014.2015.1012950

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant

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Published: 2014-04-04   Modified: 2019-03-29  

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