| Project/Area Number |
26461047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAWADA Kenro 東京医科歯科大学, 医学部付属病院, 講師 (20311219)
TAKUBO Kaiyo 東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究部長 (00154956)
KAWANO Tatsuyuki 東京医科歯科大学, 医歯(薬)総合研究科, 教授 (00186115)
ISHIDA Hideyuki 埼玉医科大学, 医学部, 教授 (00262197)
ISHIGURO Toru 埼玉医科大学, 医学部, 講師 (10383241)
HIGASHI Morihiro 埼玉医科大学, 医学部, 准教授 (00323395)
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| Research Collaborator |
SOBAJIMA Jun 埼玉医科大学, 医学部, 助教 (40406517)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | エンドサイトスコピーシステム / 食道癌 / 食道炎 / 血管新生 / 超拡大内視鏡 / リンパ管新生 / Endocytoscopy system / Optical biopsy / 腫瘍関連マクロファージ |
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| Outline of Final Research Achievements |
the Endocytoscopy system (ECS) is the novel ultrea-high magnifying endoscope that can allow in vivo cell observation. ECS can reduce the need of conventional histological diagnosis using biopsy histology. In terms of medical economics, ECS will cut costs by allowing histological examination to be omitted. In this study period, we determined the adequate magnifying power of ECS for recognition of nuclear abnormality. Referring our results, Olympus developed a latest prototype ECS (GIF-Y0074) that can magnify up to 500 times with high vision view. This ECS achieves a level that makes its commercial release justifiable. We reported the experience of using this latest type ECS. In addition, we reported the endocytoscopic features of esophagitis for differential diagnosis of esophageal squamous cell carcinoma (ESCC). Further, we have made effort to clarify the machanism of the morphological change of the microvasculature in superficial ESCC using immunohistochemical staining.
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