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Photodynamic diagnosis (PDD) of the detection of colitis-associated tumor by AFE (Autofluorecent endoscopy) using oral 5-ALA (5-aminolevulinic acid) during UC (ulcerative colitis) surveillance

Research Project

Project/Area Number 26461048
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionJikei University School of Medicine

Principal Investigator

Kato Tomohiro  東京慈恵会医科大学, 医学部, 教授 (40185856)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsulcerative colitis / colitic cancer / photodynamic diagnosis / 5-aminolevulinic acid / 蛍光内視鏡 / Ulcerative colitis / Photodynamic diagnosis / 5-Aminolevulinic acid / Ulcerative coitis / Colitic neoplasia / colitic neoplasia
Outline of Final Research Achievements

Early diagnosis of colitis-associated cancer and dysplasia (CC/D) through surveillance endoscopy is critical in patients with ulcerative colitis (UC). The objective of this study was to investigate the fluorescence signal localization pattern in autofluorescence endoscopy (AFE) following 5-aminolevulinic acid (5-ALA) administration in tumorous lesions diagnosed histopathologically as CC/D, and to evaluate the sensitivity and specificity of detection of tumorous lesions by white light endoscopy (WLE) observation with and without AFE observation. In conclusion, AFE using 5-ALA can detect CC/D lesions in patients with long-standing UC, including some lesions that are not detected with WLE. The results indicated that Lesions that could not be detected with WLE could be detected with AFE. In addition, distinctive fluorescence patterns in lesions could allow qualitative diagnosis of the CC/D lesions.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 潰瘍性大腸炎関連腫瘍の検出に対する、腫瘍親和性物質を用いた光線力学的診断2015

    • Author(s)
      岩崎哲良, 加藤智弘 他
    • Journal Title

      Prog of Dig Endosc

      Volume: 86 Pages: 83-86

    • NAID

      130005084328

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 潰瘍性大腸炎関連腫瘍の検出に対する, 腫瘍親和性物質を用いた光線力学的診断2015

    • Author(s)
      岩﨑哲良,加藤智弘,他.
    • Journal Title

      Prog Dig Endosc (in press)

      Volume: 86

    • NAID

      130005084328

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 潰瘍性大腸炎関連腫瘍の検出に対する 腫瘍親和性物質を用いた光線力学的診断2016

    • Author(s)
      小川まい子,加藤智弘ら
    • Organizer
      第34回日本大腸検査学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] Visualization of endoscopically undetectable dysplasia in patients with ulcerative colitis following sensitization with oral 5-aminolevulinic acid2015

    • Author(s)
      Tetsuyoshi Iwasaki, Tomohiro Kato, et al.
    • Organizer
      DDW (Digestive Disease Week) 2015
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-05-16 – 2015-05-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Visualization of endoscopically undetectable dysplasia in patients with ulcerative colitis following sensitization with oral 5-aminolevulinic acid2015

    • Author(s)
      Tetsuyoshi Iwasaki, Tomohiro Kato, et al.
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-05-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 潰瘍性大腸炎関連腫瘍の検出に対する, 腫瘍親和性物質を用いた光線力学的診断2014

    • Author(s)
      加藤智弘 他.
    • Organizer
      第99回日本消化器内視鏡学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Research-status Report
  • [Presentation] VISUALISATION OF ENDOSCOPICALLY UNDETECTABLE DYSPLASIA IN PATIENTS WITH ULCERATIVE COLITIS FOLLOWING SENSITIZATION WITH ORAL 5-AMINOLEVULINIC ACID2014

    • Author(s)
      Tetsuyoshi Iwasaki, Tomohiro Kato, et al.
    • Organizer
      UEGW (United European Gastroenterology Week)2014
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Research-status Report
  • [Presentation] VISUALISATION OF ENDOSCOPICALLY UNDETECTABLE DYSPLASIA IN PATIENTS WITH ULCERATIVE COLITIS FOLLOWING SENSITIZATION WITH ORAL 5-AMINOLEVULINIC ACID2014

    • Author(s)
      Tetsuyoshi Iwasaki, Tomohiro Kato, et al.
    • Organizer
      DDW (Digestive Disease Week) 2014
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2014-05-03 – 2014-05-06
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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