| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
BACKGROUND & AIMS: The first aim of this study is to validate the newly developed bioelectrical admittance method (BAM) in-vitro and in-vivo experiment. METHOD: Impedance was measured using a frequency response analyzer with Caco-2 monolayer and 3D tissue. Next, BAM was clinically applied to the evaluation of esophageal mucosal permeability in heartburn patients without esophageal mucosal break. RESULTS: Impedance was highest with monolayer Caco-2 on 8 layers of normal human dermal fibroblasts. In addition, the admittance value varied depending on the treatment course of the patient. CONCLUSION: BAM detected an abnormality of the subepithelial layer of the esophagus. This measurement was also clinically useful in assessing the permeability of the esophageal mucosa under upper gastrointestinal endoscopy.
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