Development of hybrid-conditioning methods to salvage myocardium and elucidation of HSP mediated cardioprotection
Project/Area Number |
26461052
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Asahikawa Medical College |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
蓑島 暁帆 旭川医科大学, 医学部, 特任助教 (90645962)
長谷部 直幸 旭川医科大学, 医学部, 教授 (30192272)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 急性心筋梗塞 / 再灌流障害 / 熱ショック蛋白 / ポストコンディショニング / リモート・コンディショニング / ハイブリッド・コンディショニング / リモートコンディショニング / 経皮的冠動脈インターベンション / 経皮的冠動脈インターベンション |
Outline of Final Research Achievements |
The first acute myocardial infarction patients were randomly assigned to the control group and the hybrid-conditioning group. In the hybrid-conditioning group, three cycles of remote preconditioning were repeated, with the lower limb being pressurized for 5 minutes and depressurized for 5 minutes. After remote preconditioning, postconditioning was performed 4 cycles of 60s balloon inflation and 30s deflation, and finally the appropriate sized stent was placed. In both groups, blood was collected over time with time before and after reperfusion treatment, and the expression level of HSP72 in the separated leukocytes was quantitatively evaluated. Hybrid-conditioning method was shown to increase the expression of HSP 72, resulting in suppression of reperfusion injury.
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Insight into specific pro-arrhythmic triggers in Brugada and early repolarization syndromes: results of long-term follow-up.2016
Author(s)
Talib AK, Sato N, Myojo T, Sugiyama E, Nakagawa N, Sakamoto N, Tanabe Y, Fujino T, Takeuchi T, Akasaka K, Matsuhashi H, Saijo Y, Kawamura Y, Doi A, Hasebe N.
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Journal Title
Heart Vessels
Volume: 31
Issue: 12
Pages: 2035-2044
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Late Gadolinium Enhancement on Cardiac MRI Correlates with QT Dynamicity Represented by QT/RR Relationship in Patients with Ventricular Arrhythmias.2015
Author(s)
Sakamoto N, Sato N, Talib AK, Sugiyama E, Minoshima A, Tanabe Y, Fujino T, Takeuchi T, Akasaka K, Saijo Y, Kawamura Y, Hasebe N.
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Journal Title
Ann Noninvasive Electrocardiol
Volume: 7
Issue: 2
Pages: 24-24
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Late gadolinium enhancement of cardiac magnetic resonance imaging indicates abnormalities of time-domain T-wave alternans in hypertrophic cardiomyopathy with ventricular tachycardia.2015
Author(s)
Sakamoto N, Sato N, Oikawa K, Karim Talib A, Sugiyama E, Minoshima A, Tanabe Y, Takeuchi T, Akasaka K, Saijo Y, Kawamura Y, Hasebe N.
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Journal Title
Heart Rhythm
Volume: 12
Pages: 1747-1755
Related Report
Peer Reviewed
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[Journal Article] Visit-to-visit variability and seasonal variation in blood pressure: Combination of Antihypertensive Therapy in the Elderly, Multicenter Investigation (CAMUI) Trial subanalysis.2015
Author(s)
Sato N, Saijo Y, Sasagawa Y, Morimoto H, Takeuchi T, Sano H, Koyama S, Takehara N, Morita K, Sumitomo K, Maruyama J, Kikuchi K, Hasebe N; CAMUI Investigators.
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Journal Title
Clin Exp Hypertens
Volume: 37
Pages: 411-419
Related Report
Peer Reviewed
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[Journal Article] Late gadolinium enhancement on cardiac magnetic resonance represents the depolarizing and repolarizing electrically damaged foci causing malignant ventricular arrhythmia in hypertrophic cardiomyopathy.2015
Author(s)
Sakamoto N, Kawamura Y, Sato N, Nimura A, Matsuki M, Yamauchi A, Kanno T, Tanabe Y, Takeuchi T, Natori S, Saijo Y, Aburano T, Hasebe N.
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Journal Title
Heart Rhythm.
Volume: 12
Pages: 1276-1284
Related Report
Peer Reviewed
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[Presentation] A Combination of 123I-BMIPP SPECT and Stress 201Tl Myocardial Perfusion SPECT as a Useful Prognostic Marker of Asymptomatic Patients with Non-obstructive Hypertrophic Cardiomyopathy2015
Author(s)
Toshiharu Takeuchi, Masahide Goto, Makoto Aita, Taiki Hayasaka, Ayumi Date, Eitaro Sugiyama, Akiho Minoshima, Naka Sakamoto, Yasuko Tanabe, Nobuyuki Sato, Naoyuki Hasebe
Organizer
American College of Cardiology 64th Scientific Session 2015
Place of Presentation
San Diego, United States
Year and Date
2015-03-14 – 2015-03-16
Related Report
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