| Project/Area Number |
26461060
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
久木山 清貴 山梨大学, 総合研究部, 教授 (00225129)
川端 健一 山梨大学, 総合研究部, 講師 (30345706)
中村 和人 山梨大学, 総合研究部, 助教 (30456488)
尾畑 純栄 山梨大学, 総合研究部, 講師 (60362076)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | Remote conditioning / 心不全 / バイオマーカー / remote conditioning / 内皮機能 / 拡張不全 |
|---|
| Outline of Final Research Achievements |
In this study, we investigated the effects of remote ischemic conditioning for patients with heart failure with preserved ejection fraction (EF>40%). Thirty patients were randomly assigned to receive remote ischemic conditioning (for 3 days) or as control. All patients were followed up for <2 years or until the occurrences of clinical endpoints including death and admission with heart failure. During follow up periods, 13 endpoints were observed. However, there were no significant differences in occurrence of clinical endpoints between 2 groups (5 patients [33%], in remote conditioning, vs. 8patients [53%], in control, p=0.27). Moreover, assessment of biomarkers including BNP and troponin-T at 7-10days after assignment showed that both biomarker levels were more reduced in remote conditioning group compared with control group.
|
