Prediction of reverse remodeling after beta-blocker therapy in patients with newly onset left ventricular dysfunction
| Project/Area Number |
26461061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
KOYAMA Jun 信州大学, 学術研究院医学系, 准教授 (10303463)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 拡張型心筋症 / β遮断薬 / 左室駆出率 / Reverse remodeling / スペックルトラッキング / 心不全 / スペックルトラッキングエコー |
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| Outline of Final Research Achievements |
We prospectively examined 23 consecutive adult patients with dilated cardiomyopathy. LV reverse remodeling (RR) was defined as an absolute increase in LV ejection fraction of >10% at 6 months follow-up. Left ventricular hypertrabeculation (LVHT) area was calculated by subtraction from the outer edge to the inner edge of the LVHT at end-systole.
The mean follow-up period was 61 months. LVRR was observed in 9 patients (39%). The changes in the mean LVHT area showed significant correlation with the changes in LV ejection fraction (r= 0.78, P<0.0001). Cardiac death occurred in 7 patients (50%) without LVRR, but no patients with LVRR died (log-rank, P=0.003). Furthermore, composite of cardiac death and hospitalization of heart failure occurred in 10 patients (71%) without LVRR, whereas there was one patient with LVRR (log-rank, P<0.001).Regression of LVHT is associated with improvement in LV systolic function. LVRR might be associated with a favorable prognosis in patients with LVHT.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Comparison of the standard and speckle tracking echocardiographic features of wild type and mutated transthyretin cardiac amyloidoses.2016
Author(s)
Minamisawa M, Koyama J, Sekijima Y, Ikeda S-I, Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A, Izawa A, Ikeda U.
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Journal Title
Eur Heart J Cardiovasc Imaging
Volume: 17
Issue: 4
Pages: 402-10
DOI
Related Report
Peer Reviewed
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[Journal Article] Left ventricular deformation and torsion assessed by speckle-tracking echocardiography in patients with mutated transthyretin-associated cardiac amyloidosis and the effect of diflunisal on myocardial function.2015
Author(s)
Koyama J, Minamisawa M, Sekijima Y, Ikeda S-I, Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A, Izawa A, Ikeda U.
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Journal Title
IJC Heart & Vasculature
Volume: 9
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 心アミロイドーシス2016
Author(s)
小山 潤
Organizer
第８０回日本循環器学会学術集会
Place of Presentation
仙台国際会議場
Year and Date
2016-03-20
Related Report
Invited
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