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Prediction of reverse remodeling after beta-blocker therapy in patients with newly onset left ventricular dysfunction

Research Project

Project/Area Number 26461061
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionShinshu University

Principal Investigator

KOYAMA Jun  信州大学, 学術研究院医学系, 准教授 (10303463)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords拡張型心筋症 / β遮断薬 / 左室駆出率 / Reverse remodeling / スペックルトラッキング / 心不全 / スペックルトラッキングエコー
Outline of Final Research Achievements

We prospectively examined 23 consecutive adult patients with dilated cardiomyopathy. LV reverse remodeling (RR) was defined as an absolute increase in LV ejection fraction of >10% at 6 months follow-up. Left ventricular hypertrabeculation (LVHT) area was calculated by subtraction from the outer edge to the inner edge of the LVHT at end-systole.
The mean follow-up period was 61 months. LVRR was observed in 9 patients (39%). The changes in the mean LVHT area showed significant correlation with the changes in LV ejection fraction (r= 0.78, P<0.0001). Cardiac death occurred in 7 patients (50%) without LVRR, but no patients with LVRR died (log-rank, P=0.003). Furthermore, composite of cardiac death and hospitalization of heart failure occurred in 10 patients (71%) without LVRR, whereas there was one patient with LVRR (log-rank, P<0.001).Regression of LVHT is associated with improvement in LV systolic function. LVRR might be associated with a favorable prognosis in patients with LVHT.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (6 results) (of which Invited: 2 results)

  • [Journal Article] Regression of left ventricular hypertrabeculation is associated with improvement in systolic function and favorable prognosis in adult patients with non-ischemic cardiomyopathy.2016

    • Author(s)
      Minamisawa M, Koyama J, Kozuka A, Miura T, Ebisawa S, Motoki H, Okada A, Izawa A, Ikeda U.
    • Journal Title

      J Cardiol

      Volume: 68 Issue: 5 Pages: 431-438

    • DOI

      10.1016/j.jjcc.2015.11.008

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Author's reply.2016

    • Author(s)
      Minamisawa M, Koyama J, Ikeda U.
    • Journal Title

      J Cardiol

      Volume: 68 Issue: 4 Pages: 359-360

    • DOI

      10.1016/j.jjcc.2016.03.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the standard and speckle tracking echocardiographic features of wild type and mutated transthyretin cardiac amyloidoses.2016

    • Author(s)
      Minamisawa M, Koyama J, Sekijima Y, Ikeda S-I, Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A, Izawa A, Ikeda U.
    • Journal Title

      Eur Heart J Cardiovasc Imaging

      Volume: 17 Issue: 4 Pages: 402-10

    • DOI

      10.1093/ehjci/jew003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolated left ventricular non-compaction cardiomyopathy in adults2015

    • Author(s)
      Ikeda U, Minamisawa M, Koyama J.
    • Journal Title

      J Cardiol

      Volume: 65 Pages: 91-97

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Left ventricular deformation and torsion assessed by speckle-tracking echocardiography in patients with mutated transthyretin-associated cardiac amyloidosis and the effect of diflunisal on myocardial function.2015

    • Author(s)
      Koyama J, Minamisawa M, Sekijima Y, Ikeda S-I, Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A, Izawa A, Ikeda U.
    • Journal Title

      IJC Heart & Vasculature

      Volume: 9 Pages: 1-10

    • DOI

      10.1016/j.ijcha.2015.07.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of azelnidipine and amlodipine on left ventricular mass and longitudinal function in hypertensive patients with left ventricular hypertrophy.2014

    • Author(s)
      Motoki H, Koyama J, Izawa A, Tomita T, Miyashita Y, Takahashi M, Ikeda U.
    • Journal Title

      Echocardiography

      Volume: 31(10) Issue: 10 Pages: 1230-1238

    • DOI

      10.1111/echo.12548

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 成人の左室緻密化障害の全国調査結果報告2017

    • Author(s)
      南澤匡俊、小山潤、桑原浩一郎、池田宇一
    • Organizer
      第3回日本心筋症研究会
    • Place of Presentation
      岐阜 長良川国際会議場
    • Year and Date
      2017-04-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] 心アミロイドーシス2016

    • Author(s)
      小山 潤
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際会議場
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Long-term prognostic significance of diastolic wall strain, mid-wall shortening, and global longitudinal strain in patients with light-chain amyloidosis.2016

    • Author(s)
      Kozuka A, Koyama J, et al.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際会議場
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 心アミロイドーシスのタイプ別治療介入2016

    • Author(s)
      小山 潤
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台市民会館
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Duration of myocardial early systolic lengthening in left anterior descending coronary artery is correlated with fractional flow reserve.2016

    • Author(s)
      Minamisawa M, Koyama J, et al.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際会議場
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 冠血流予備量比と収縮早期左室心筋伸展(Early systolic lengthening)の関連について2015

    • Author(s)
      南澤匡俊、小山 潤、池田宇一
    • Organizer
      日本超音波医学会第88回学術集会 循環器奨励賞演題
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2015-05-22
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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