Prognostic impact of left atrial strain in patients with heart failure with preserved ejection fraction

• Project/Area Number: 26461063
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Shinshu University
• Principal Investigator: MOTOKI Hirohiko 信州大学, 学術研究院医学系(医学部附属病院), 講師 (50532058)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 心不全 / 左室駆出率保持 / 高齢者 / 心房機能 / 予後予測 / 拡張不全 / 左房機能 / スペックルトラッキング / 予後予測指標

Outline of Final Research Achievements

414 patients were enrolled in this study. Median age was 81 years, and mean left ventricular ejection fraction was 48%. Approximately 50% of patients showed preserved ejection fraction (LVEF>50%). Primary end-point was composite of all cause death, non-fatal myocardial infarction, non-fatal stroke, and unexpected admission for heart failure. Patients are going to be followed up for 3 years.
In this study, more females with preserved ejection fraction were affected heart failure in octogenarians. Anemia, renal insufficiency, and increased arterial stiffness were evident in our population.

Research Products

• [Journal Article] Prognostic Significance of Neuroadrenergic Dysfunction for Cardiovascular Events in Patients With Acute Myocardial Infarction (2015)
  • Author(s): Minamisawa M, Izawa A, Motoki H, Kashima Y, Hioki H, Abe N, Miura T, Ebisawa S, Miyashita Y, Koyama J, Ikeda U.
  • Journal Title: Circulation Journal Volume: 79 Issue: 10 Pages: 2238-2245
  • DOI: 10.1253/circj.CJ-15-0265
  • NAID: 130005099848
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of right ventricular longitudinal strain in patients with ischemic cardiomyopathy: Head to head comparison between two-dimensional sepckle-based strain and velocity vector imaging using volumetric assessment by cardiac magnetic resonance as a "Gold Standard". (2015)
  • Author(s): Park JH, Kusunose K, Motoki H, Kwon DH, Grimm RA, Griffin BP, Marwick TH, Popovic ZB.
  • Journal Title: Echocardiography Volume: 32 Issue: 6 Pages: 956-965
  • DOI: 10.1111/echo.12740
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pericardiectomy is associated with improvement in longitudinal displacement of left ventricular free wall due to increased counterclockwise septal-to-lateral rotational displacement (2015)
  • Author(s): Negishi, Popovic ZB, Negishi T, Motoki H, Alraies MC, Chirakarnjankorn S, Dahiya A, Klein AL.
  • Journal Title: J Am Soc Echocardiogr Volume: 28 Pages: 1204-1213
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Impact of Rapid Reduction of Low-Density Lipoprotein Cholesterol Level on Long-Term Outcome of Acute Myocardial Infarction in the Statin Era: Subanalysis of the ALPS-AMI Study. (2015)
  • Author(s): Miura T, Izawa A, Motoki H, Miyashita Y, Kashima Y, Ebisawa S, Tomita T, Koyama J, Ikeda U.
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0127835-e0127835
  • DOI: 10.1371/journal.pone.0127835
  • Peer Reviewed / Open Access
• [Journal Article] Right ventricular global longitudinal strain provides prognostic value incremental to left ventricular ejection fraction in patients with heart failure. (2014)
  • Author(s): Motoki H, Borowski AG, Shrestha K, Hu B, Kusunose K, Troughton RW, Tang WH, Klein AL.
  • Journal Title: J Am Soc Echocardiogr Volume: 27(7) Issue: 7 Pages: 726-732
  • DOI: 10.1016/j.echo.2014.02.007
  • Peer Reviewed
• [Journal Article] Impact of azelnidipine and amlodipine on left ventricular mass and longitudinal function in hypertensive patients with left ventricular hypertrophy. (2014)
  • Author(s): Motoki H, Koyama J, Izawa A, Tomita T, Miyashita Y, Takahashi M, Ikeda U.
  • Journal Title: Echocardiography Volume: 31(10) Issue: 10 Pages: 1230-1238
  • DOI: 10.1111/echo.12548
  • Peer Reviewed
• [Journal Article] Global left atrial strain in the prediction of sinus rhythm maintenance after catheter ablation for atrial fibrillation. (2014)
  • Author(s): Motoki H, Negishi K, Kusunose K, Popovic ZB, Bhargava M, Wazni OM, Saliba WI, Chung MK, Marwick TH, Klein AL.
  • Journal Title: J Am Soc echocardiogr Volume: 27(11) Issue: 11 Pages: 1184-1192
  • DOI: 10.1016/j.echo.2014.08.017
  • Peer Reviewed
• [Journal Article] 成人先天性心疾患 (2014)
  • Author(s): 元木博彦
  • Journal Title: 信州医誌 Volume: 62(5) Pages: 285-294
  • NAID: 130004707075
• [Presentation] Characteristics of elderly patients with Heart Failure with Preserved Ejection Fraction: From CURE-HF Registry (2017)
  • Author(s): Hirohiko Motoki, Masatoshi Minamisawa, Kazuhiro Kimura, Satoko Higuchi, Saeko Yamazaki, Atsushi Izawa, Koichiro Kuwahara.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市教育プラザ
  • Year and Date: 2017-03-17
• [Presentation] Clinical Profiles of Octogenarians with Heart Failure: From CURE-Heart Failure Registry (2017)
  • Author(s): Hirohiko Motoki, Masatoshi Minamisawa, Kazuhiro Kimura, Satoko Higuchi, Saeko Yamazaki, Atsushi Izawa, Koichiro Kuwahara.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市教育プラザ
  • Year and Date: 2017-03-17
• [Presentation] Characteristics of Elderly Patients with Heart Failure with Preserved Ejection Fraction: From CURE-HF Registry (2016)
  • Author(s): Hirohiko Motoki, Masatoshi Minamisawa, Kazuhiro Kimura, Satoko Higuchi, Saeko Yamazaki, Atsushi Izawa, Uichi Ikeda.
  • Organizer: The 80th Annual Scientific Meeting of Japanese Circulation Society
  • Place of Presentation: 宮城県（仙台国際センター）
  • Year and Date: 2016-03-18
• [Presentation] Clinical Profiles of Octogenarians with Heart Failure: From CURE-Heart Failure Registry (2016)
  • Author(s): Hirohiko Motoki, Masatoshi Minamisawa, Kazuhiro Kimura, Satoko Higuchi, Saeko Yamazaki, Atsushi Izawa, Uichi Ikeda.
  • Organizer: The 80th Annual Scientific Meeting of Japanese Circulation Society
  • Place of Presentation: 宮城県（仙台国際センター）
  • Year and Date: 2016-03-18
• [Presentation] Comparison of usefulness of coronary SYNTAX score in patients with prior heart failure with preserved ejection fraction versus with reduced ejection fraction: a sub-analysis of shinano registry. (2015)
  • Author(s): Minamisawa M, Miura T, Motoki H, Hioki H, Hashizume N, Abe N, Ebisawa S, Izawa A, Koyama J, Ikeda U.
  • Organizer: ESC Congress 2015
  • Place of Presentation: UK（London）
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Risk stratification using the CHADS2 score in patients with coronary heart disease undergoing percutaneous coronary intervention. (2015)
  • Author(s): Hioki H, Miura T, Miyashita Y, Motoki H, Shimada K, Kobayashi M, Kimura H, Mawatari E, Ebisawa S, Ikeda U.
  • Organizer: ESC Congress 2015
  • Place of Presentation: UK（London）
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Radial versus femoral access for primary percutaneous interventions in elderly patients with acute coronary syndrome : A subanalysis of the shinano registry. (2015)
  • Author(s): Miura T, Miyashita Y, Motoki H, Shimada K, Kobayashi M, Nakajima H, Kimura H, Akanuma H, Mawatari E, Sato T, Hotta S, Kamiyoshi Y, Maruyama T, Watanabe N, Eisawa T, Aso S, Uchikawa S, Hashizume N, Sekimura N, Morita T, Ebisawa S, Izawa A, Tomita T, Koyama J, Ikeda U.
  • Organizer: 米国心臓病学会議
  • Place of Presentation: サンディアゴ（アメリカ）
  • Year and Date: 2015-03-14 – 2015-03-16
• [Presentation] Incremental prognostic value of assessing growth differentiation factor-15 in patients with acute myocardial infarction -ALPS AMI Subanalysis -. (2014)
  • Author(s): Minamisawa M, Motoki H, Izawa A, Kashima Y, Yanagisawa T, Hioki H, Abe N, Miura T, Ebisawa S, Tomita T, Miyashita Y, Koyama J, Ikeda U.
  • Organizer: 欧州心臓病学会議
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Low-density lipoprotein cholesterol paradox on long-term outcome of acute myocardial infarction in the statin era: subanalysis of the ALPS-AMI. (2014)
  • Author(s): Miura T, Izawa A, Motoki H, Miyashita Y, Kashima Y, Ebisawa S, Tomita T, Koyama J, Ikeda U.
  • Organizer: 日本心血管インターベンション治療学会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] Renewed Impact of Lidocaine on Refractory Ventricular Arrhythmias in the Amiodarone Era. (2014)
  • Author(s): Yoshie K,Tomita T, Takeuchi T, Okada A, Ebisawa S, Miura T, Motoki H, Shiba Y, Izawa A, Miyashita Y, Koyama J,Ikeda U.
  • Organizer: CARDIOSTIM - EHRA EUROPACE
  • Place of Presentation: ニース（フランス）
  • Year and Date: 2014-06-18 – 2014-06-21