The role of focal discharge and reentry on atrial fibrillation

Research Project

Project/Area Number	26461066
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cardiovascular medicine
Research Institution	Nagoya University
Principal Investigator	Ueda Norihiro 名古屋大学, 環境医学研究所, 助教 (10456709)
Co-Investigator(Renkei-kenkyūsha)	HONJO Haruo 名古屋大学, 環境医学研究所, 准教授 (70262912)
Project Period (FY)	2014-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	心房細動 / 急性心不全
Outline of Final Research Achievements	Inducibility of atrial fibrillation (AF) was increased by an acute stretch of atrium with the heterogeneous conduction pattern and the shortening of effective refractory period. The elevation of atrial pressure caused the shortening of effective refractory period of atrium. Conduction of atrium spread throughout all pulmonary veins. The pulmonary vein may be the key factor for AF occurrence and maintenance. Stretch activated channel and calmodulin kinase might be the targets for the therapy for AF.