Epidemiological study for Japanese patients with venous thromboembolism

• Project/Area Number: 26461067
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Mie University
• Principal Investigator: Nakamura Mashio 三重大学, 医学系研究科, リサーチアソシエイト (40293774)
• Co-Investigator(Kenkyū-buntansha): 伊藤 正明 三重大学, 医学系研究科, 教授 (00223181) ; 山田 典一 三重大学, 医学系研究科, 准教授 (60303731)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 静脈血栓塞栓症 / 抗凝固療法 / ワルファリン / 新規経口抗凝固薬 / 静脈血栓症 / 肺塞栓症 / 深部静脈血栓症 / 再発 / 出血

Outline of Final Research Achievements

We conducted the observational study evaluating the efficacy and the bleeding risk of novel anticoagulants and conventional agents in Japanese patients with venous thromboembolism (VTE) in a variety of situations. Four observational studies have been started and in the period of registration and follow-up. In these study, a lot of VTE patients have been prescribed novel anticoagulants. Furthermore, we reviewed current status of anticoagulation for VTE patients in Japan. It showed the problem of treatment in Japan and the expected benefit of novel anticoagulants.

Research Products

• [Journal Article] Direct Oral Anticoagulants for the Treatment of Venous Thromboembolism in Japan. (2017)
  • Author(s): Nakamura M, Yamada N, Ito M
  • Journal Title: J Atheroscler Thromb Volume: in press
  • NAID: 130005687825
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Novel Anticoagulant Therapy of Venous (2017)
  • Author(s): Nakamura M, Yamada N, Ito M
  • Journal Title: Ann Vasc Dis Volume: in press
  • Peer Reviewed / Open Access
• [Journal Article] Mechanical prophylaxis is a heparin-independent risk for anti-platelet factor 4/heparin antibody formation after orthopedic surgery (2016)
  • Author(s): Bito S, Miyata S, Migita K, Nakamura M, Shinohara K, Sato T, Tonai T, Shimizu M, Shibata Y, Kishi K, Kubota C, Nakahara S, Mori T, Ikeda K, Ota S, Minamizaki T, Yamada S, Shiota N, Kamei M, Motokawa S
  • Journal Title: Blood Volume: 127(8) Issue: 8 Pages: 1036-1043
  • DOI: 10.1182/blood-2015-06-651620
• [Journal Article] Efficacy and safety of edoxaban versus enoxaparin for the prevention of venous thromboembolism following total hip arthroplasty: STARS J-V. (2015)
  • Author(s): Yamada N, Hanzawa K, Ota S, Nakamura M, Sato K, Ikura M, Suzuki T, Kaise T, Nakajima H, Ito M
  • Journal Title: Thromb J Volume: 12 Issue: 1 Pages: 13-27
  • DOI: 10.1186/s12959-015-0057-x
• [Journal Article] Apixaban for the Treatment of Japanese Subjects With Acute Venous Thromboembolism (AMPLIFY-J Study) (2015)
  • Author(s): Nakamura M, Nishikawa M, Komuro I, Kitajima I, Uetsuka Y, Yamagami T, Minamiguchi H, Yoshimatsu R, Tanabe K, Matsuoka N, Kanmuri K, Ogawa H
  • Journal Title: Circulation Journal Volume: 79 Issue: 6 Pages: 1230-1236
  • DOI: 10.1253/circj.CJ-15-0195
  • NAID: 130005073151
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Current management of venous thromboembolism in Japan: Current epidemiology and advances in anticoagulant therapy (2015)
  • Author(s): Nakamura M, Yamada N, Ito M
  • Journal Title: J Cardiol Volume: 66(6) Issue: 6 Pages: 451-459
  • DOI: 10.1016/j.jjcc.2015.03.012
• [Journal Article] Risk of venous thromboembolism after total knee arthroplasty in patients with rheumatoid (2015)
  • Author(s): Izumi M, Migita K, Nakamura M, Jiuchi Y, Sakai T, Yamaguchi T, Asahara T,
  • Journal Title: J Rheumatol Volume: 42(6) Issue: 6 Pages: 928-934
  • DOI: 10.3899/jrheum.140768
• [Journal Article] Changes in the incidence, case fatality rate, and characteristics of symptomatic (2015)
  • Author(s): Kuroiwa M, Morimatsu H, Tsuzaki K, Irita K, Sanuki M, Nakatsuka H, Nakamura M
  • Journal Title: J Anesth Volume: 29(3) Issue: 3 Pages: 433-441
  • DOI: 10.1007/s00540-014-1939-y
• [Journal Article] Changes in the incidence, case fatality rate, and characteristics of symptomatic perioperative pulmonary thromboembolism in Japan: Results of the 2002-2011 Japanese Society of Anesthesiologists Perioperative Pulmonary Thromboembolism (JSA-PTE) Study. (2014)
  • Author(s): Kuroiwa M, Morimatsu H, Tsuzaki K, Irita K, Sanuki M, Nakatsuka H, Nakamura M.
  • Journal Title: J Anesth Volume: Epub
  • Peer Reviewed
• [Journal Article] Venous thromboembolism after total joint arthroplasty: results from a Japanese multicenter cohort study (2014)
  • Author(s): Migita K, Bito S, Nakamura M, Miyata S, Saito M, Kakizaki H, Nakayama Y, Matsusita T, Furuichi I, Sasazaki Y, Tanaka T, Yoshida M, Kaneko H, Abe I, Mine T, Ihara K, Kuratsu S, Saisho K, Miyahara H, Segata T, Nakagawa Y, Kamei M, Torigoshi T, Motokawa S.
  • Journal Title: Arthritis Res Ther Volume: 16 Issue: 4
  • DOI: 10.1186/ar4616
  • Peer Reviewed
• [Journal Article] Current venous thromboembolism management and outcomes in Japan (2014)
  • Author(s): Nakamura M, Miyata T, Ozeki Y, Takayama M, Komori K, Yamada N, Origasa H, Satokawa H, Maeda H, Tanabe N, Unno N, Shibuya T, Tanemoto K, Kondo K, Kojima T
  • Journal Title: Circ J Volume: 78 Pages: 708-717