The establishment of nutrition therapy and the pathophysiological assessment for cardiac cachexia and aspiration pneumonia with targeting sarcopenia.

• Project/Area Number: 26461068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: YAMAMOTO TAKASHI 滋賀医科大学, 医学部, 講師 (80378447)
• Co-Investigator(Kenkyū-buntansha): 三木 誓雄 三重大学, 医学系研究科, 客員教授 (50242962) ; 堀江 稔 滋賀医科大学, 医学部, 教授 (90183938)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 心不全 / 栄養障害 / サルコペニア / 心臓悪液室 / 心臓悪液質

Outline of Final Research Achievements

We evaluated the nutritional status of patients with chronic heart failure (CHF) by body composition analysis and indirect calorimetry. 34 patients with chronic heart failure and 19 control subjects were recruited in this study. In results, the patients with severe CHF have malnutrition characterized by the reduction of body fat and skeletal muscle mass of lower limbs compared to control subjects. Furthermore, in patients with severe CHF, the energy consumption tends to exceed the energy intake, resulting in the negative energy balance. The reason of the negative energy balance in patients with CHF is due to both the reduction of energy intake and the acceleration of the energy consumption. The negative energy balance is likely to be deteriorated as the severity of CHF is worsened.

Research Products

• [Journal Article] Contribution of a KCNH2 variant in genotyped long QT syndrome: Romano-Ward syndrome under double mutations and acquired long QT syndrome under heterozygote. (2017)
  • Author(s): Fujii Y, Horie M, et al.
  • Journal Title: J Cardiol Volume: 印刷中 Issue: 1 Pages: 74-79
  • DOI: 10.1016/j.jjcc.2016.09.010
  • Peer Reviewed / Open Access
• [Journal Article] Significance of integrated in silico 2-dimensional transmural ventricular wedge preparation models of human non-failing and failing hearts for evaluation of drug candidates cardiac safety. (2017)
  • Author(s): Kubo T, Horie M, et al.
  • Journal Title: Journal of Pharmacological and Toxicological Methods Volume: 83 Pages: 30-41
  • DOI: 10.1016/j.vascn.2016.08.007
  • Peer Reviewed / Open Access
• [Journal Article] Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population. (2016)
  • Author(s): Hisamatsu T, Fujiyoshi A, Miura K, Ohkubo T, Sekikawa A, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, et ai.
  • Journal Title: Atherosclerosis. Volume: 246 Pages: 141-147
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inter-Facility Transfer vs. Direct Admission of Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (2016)
  • Author(s): Nakatsuma K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Yamamoto T, Suwa S, Horie M, Kimura T; CREDO-Kyoto AMI investigators.
  • Journal Title: Circulation Journal Volume: 80 Issue: 8 Pages: 1764-1772
  • DOI: 10.1253/circj.CJ-16-0204
  • NAID: 130005166115
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men. (2016)
  • Author(s): Hisamatsu T, Miura K, Arima H, Kadota A, Kadowaki S, Torii S, Suzuki S, Miyagawa N, Sato A, Yamazoe M, Fujiyoshi A, Ohkubo T, Yamamoto T, Murata K, Abbott RD, Sekikawa A, Horie M, Ueshima H; Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group
  • Journal Title: J Am Heart Assoc. Volume: 29 Issue: 9
  • DOI: 10.1161/jaha.116.003738
  • NAID: 120006334825
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial. (2016)
  • Author(s): Kaitani K, Inoue k, Kobori A, Nakazawa Y, Ozawa T, et al.
  • Journal Title: European Heart Journal. Volume: 7 Issue: 7 Pages: 610-618
  • DOI: 10.1093/eurheartj/ehv501
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Culprit Vessel-Only vs. Staged Multivessel Percutaneous Coronary Intervention Strategies in Patients With Multivessel Coronary Artery Disease Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction (2016)
  • Author(s): Toyota T, Shiomi H, Taniguchi T, Morimoto T, Furukawa Y, Nakagawa Y, Horie M, Kimura T.
  • Journal Title: Circulation Journal Volume: 80 Issue: 2 Pages: 371-378
  • DOI: 10.1253/circj.CJ-15-0493
  • NAID: 130005120893
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components: Shiga Epidemiological Study of Subclinical Atherosclerosis. (2016)
  • Author(s): Yamazoe M, Hisamatsu T, Miura K, Kadowaki S, Zaid M, Kadota A, Torii S, Miyazawa I, Fujiyoshi A, Arima H, Sekikawa A, Maegawa H, Horie M, Ueshima H; SESSA Research Group.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 8 Pages: 1703-1708
  • DOI: 10.1161/atvbaha.116.307612
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lipoprotein-associated phospholipase A2 related to the risk of subclinical atherosclerosis independent of small low density lipoprotein particles in a general Japanese population. (2016)
  • Author(s): Ueshima H, Kadowaki T, Fujiyoshi A, Miura K, Ohkubo T, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, et ai.
  • Journal Title: Athelosclerosis Volume: 246 Pages: 141-147
  • DOI: 10.1016/j.atherosclerosis.2015.12.027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intravascular Ultrasound Guidance vs. Angiographic Guidance in Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction – Long-Term Clinical Outcomes From the CREDO-Kyoto AMI Registry – (2016)
  • Author(s): Nakatsuma K1, Shiomi H, Morimoto T, Ando K, Kadota K, Watanabe H, Taniguchi T, Yamamoto T, Furukawa Y, Nakagawa Y, Horie M, Kimura T.
  • Journal Title: Circulation Journal Volume: 80 Issue: 2 Pages: 477-484
  • DOI: 10.1253/circj.CJ-15-0870
  • NAID: 130005120921
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multigenerational Inheritance of Long QT Syndrome Type 2 in a Japanese Family (2016)
  • Author(s): Ichikawa M, Ohno S, Fujii Y, Ozawa J, Sonoda K, Fukuyama M, Kato K, Kimura H, Itoh H, Hayashi H, Horie M.
  • Journal Title: Internal Medicine Volume: 55 Issue: 3 Pages: 259-262
  • DOI: 10.2169/internalmedicine.55.6014
  • NAID: 130005122603
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction. (2016)
  • Author(s): Chen J, Makiyama T, Wuriyanghai Y, Ohno S, Sasaki K, Hayano M, Harita T, Nishiuchi S, Yamamoto Y, Ueyama T, Shimizu A, Horie M, Kimura T.
  • Journal Title: Heart Rhythm Volume: 13(1) Issue: 1 Pages: 289-298
  • DOI: 10.1016/j.hrthm.2015.08.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Practical applicability of landiolol, an ultra-short-acting β1-selective blocker, for rapid atrial and ventricular tachyarrhythmias with left ventricular dysfunction. (2016)
  • Author(s): Wada Y, Aiba T, Tsujita Y, Itoh H, Wada M, Nakajima I, Ishibashi K, Okamura H, Miyamoto K, Noda T, Sugano Y, Kanzaki, Toshihisa Anzai, Kengo Kusano H, Yasuda S, Horie M, Ogawa H
  • Journal Title: Journal of Arrhythmia Volume: (32) Issue: 2 Pages: 82-88
  • DOI: 10.1016/j.joa.2015.09.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pediatric Cohort With Long QT Syndrome – <i>KCNH2</i> Mutation Carriers Present Late Onset But Severe Symptoms – (2016)
  • Author(s): Ozawa, J. Ohno, S. Horie M, et al.
  • Journal Title: Circulation Journal Volume: 80 Issue: 3 Pages: 696-702
  • DOI: 10.1253/circj.CJ-15-0933
  • NAID: 130005128459
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term outcomes associated with prolonged PR interval in the general Japanese population. (2015)
  • Author(s): Hisamatsu T, Miura K, Fujiyoshi A, Okamura T, Ohkubo T, Nagasawa SY, Horie M, Okayama A, Ueshima H,
  • Journal Title: International Journal of Cardiology. Volume: 184 Pages: 291-293
  • DOI: 10.1016/j.ijcard.2015.02.028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and safety of flecainide for ventricular arrhythmias in patients with Andersen-Tawil syndrome with KCNJ2 mutations. (2015)
  • Author(s): Miyamoto K, Aiba T, Kimura H, Hayashi H, Ohno S, Yasuoka C, Tanioka Y, Tsuchiya T, Yoshida Y, Hayashi H, Tsuboi I, Nakajima I, Ishibashi K, Okamura H, Noda T, Ishihara M, Anzai T, Yasuda S, Miyamoto Y, Kamakura S, Kusano K, Ogawa H, Horie M, Shimizu W.
  • Journal Title: Heart Rhythm Volume: 12 Issue: 3 Pages: 596-603
  • DOI: 10.1016/j.hrthm.2014.12.009
  • Peer Reviewed / Open Access
• [Journal Article] Mosaic KCNJ2 mutation in Andersen-Tawil syndrome: targeted deep sequencing is useful for the detection of mosaicism. (2015)
  • Author(s): Hasegawa K, Ohno S, Kimura H, Itoh H, Makiyama T, Yoshida Y, Horie M.
  • Journal Title: Clin Genet Volume: 87 Issue: 3 Pages: 279-83
  • DOI: 10.1111/cge.12357
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and Pathological Impact of Tissue Fibrosis on Lethal Arrhythmic Events in Hypertrophic Cardiomyopathy Patients With Impaired Systolic Function (2015)
  • Author(s): Wada Y, Aiba T, T Matsuyama, I Nakajima, Ishibashi K, Miyamoto K, Yamada Y, Okamura H, Noda T, Satomi K, Morita Y, Kanzaki H, Kusano K, Anzai T, Kamakura S, Ishibashi-Ueda H, Shimizu Wataru, Horie M, Yasuda S, Ogawa H.
  • Journal Title: Circulation Journal Volume: 79 Issue: 8 Pages: 1733-1741
  • DOI: 10.1253/circj.CJ-15-0104
  • NAID: 130005089375
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Common Mutation of Long QT Syndrome Type 1 in Japan (2015)
  • Author(s): Itoh H, Dochi K, Shimizu W, Denjoy I, Ohno S, Aiba T, Kimura H, Kato K, Fukuyama M, Hasagawa K, Schulze-Bahr E, Guicheney P, Horie M.
  • Journal Title: Circulation Journal Volume: 79 Issue: 9 Pages: 2026-2030
  • DOI: 10.1253/circj.CJ-15-0342
  • NAID: 130005095315
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] L&ouml;ffler Endocarditis and Lacking Heart (2015)
  • Author(s): Sawayama Y, Itoh H, Sakai H, Horie M.
  • Journal Title: Internal Medicine Volume: 54 Issue: 23 Pages: 3093-3093
  • DOI: 10.2169/internalmedicine.54.5622
  • NAID: 130005112846
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between Pulse Wave Velocity and Coronary Artery Calcification in Japanese men (2015)
  • Author(s): Torii S, Arima H, Ohkubo T, Fujiyoshi A, Kadota A, Takashima N, Kadowaki S, Hisamatsu T, Saito Y, Miyagawa N, Zaid M, Murakami Y, Abbott R, Horie M, Miura K, Ueshima H.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 12 Pages: 1266-1277
  • DOI: 10.5551/jat.30247
  • NAID: 130005112368
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antiplatelet therapy discontinuation and the risk of serious cardiovascular events after coronary stenting: observations from the CREDO-Kyoto Registry Cohort-2. (2015)
  • Author(s): Watanabe H, Morimoto T, Natsuaki M, Furukawa Y, Nakagawa Y, Kadota K, Yamaji K, Ando K, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Horie M, et ai.
  • Journal Title: PLoS One Volume: 10(4) Issue: 4 Pages: e0124314-e0124314
  • DOI: 10.1371/journal.pone.0124314
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adenosine triphosphate-guided pulmonary vein isolation for atrial fibrillation: the UNmasking Dormant Electrical Reconduction by Adenosine TriPhosphate (UNDER-ATP) trial. (2015)
  • Author(s): Kobori A, Shizuta S, Inoue K, Kaitani K, Morimoto T, Nakazawa Y, Ozawa T, et al.
  • Journal Title: European Heart Journal. Volume: 7 Pages: 3276-3287
  • DOI: 10.1093/eurheartj/ehv457
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population (2014)
  • Author(s): Takashi Hisamatsu、Akira Fujiyoshi、Katsuyuki Miura、Takayoshi Ohkubo、Aya Kadota、 Sayaka Kadowaki、Takashi Kadowaki、Takashi Yamamoto、Naoko Miyagawa、Maryam Zaid、Sayuki Torii、Naoyuki Takashima、Yoshitaka Murakami、Tomonori Okamura、Minoru Horie、Hirotsugu Ueshima; for the SESSA Research Group
  • Journal Title: Atherosclerosis Volume: 236 Issue: 2 Pages: 237-243
  • DOI: 10.1016/j.atherosclerosis.2014.07.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population. (2014)
  • Author(s): Hisamatsu T, Miura K, Ohkubo T, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Okuda N, Yoshita K, Kita Y, Murakami Y, Nakamura Y, Okamura T, Horie M, Okayama A, Ueshima H, NIPPON DATA80 Research Group.
  • Journal Title: Journal of Cardiology. Volume: 64(3) Issue: 3 Pages: 218-224
  • DOI: 10.1016/j.jjcc.2014.01.005
  • Peer Reviewed
• [Journal Article] Long-term Pharmacological Therapy of Brugada Syndrome : Is Attenuation of J waves a Marker of Drug Efficacy? (2014)
  • Author(s): Hasegawa K, Ashihara T, Kimura H, Jo H, Itoh H, Yamamoto T, Aizawa Y, Horie M.
  • Journal Title: Internal Med Volume: 53(14) Pages: 1523-6
  • Peer Reviewed
• [Presentation] 意識消失発作を主訴とした成人型筋緊張性ジストロフィーの一例. 第28回滋賀不整脈研究会. (2017)
  • Author(s): 冨岡大資, 小澤友哉, 大野聖子, 伊藤英樹, 芦原貴司, 山本 孝, 堀江 稔
  • Organizer: 第28回滋賀不整脈研究会.
  • Place of Presentation: 滋賀
• [Presentation] 成人型筋強直性ジストロフィーに合併した心房粗動を治療し得た一症例. (2017)
  • Author(s): 冨岡大資、小澤友哉、大野聖子、伊藤英樹、芦原貴司、山本孝、堀江稔
  • Organizer: 第28回滋賀不整脈研究会.
  • Place of Presentation: 滋賀
• [Presentation] 経カテーテル的大動脈弁置換術(TAVI)を施行した2例. (2016)
  • Author(s): 山本孝, 八木典章, 松本祐一, 木村紘美, 酒井宏, , 森本政憲, 寺田真也, 板倉玲欧, 木村 武, 鈴木友彰, 水野隆芳, 北川裕利, 浅井 徹, 堀江稔.
  • Organizer: 第79回滋賀県循環器疾患研究会
  • Place of Presentation: 滋賀
• [Presentation] 精巣腫瘍に対するBEP療法中に認めた急性心筋梗塞の１例. (2016)
  • Author(s): 中島健太, 岡本寛樹, 冨田行則, 八木典章, 木村紘美, 松本佑一, 酒井宏, 山本孝, 堀江稔.
  • Organizer: 第122回日本循環器学会近畿地方会
  • Place of Presentation: 大阪
• [Presentation] 本当は怖い塞性動脈硬化症 (2015)
  • Author(s): 山本 孝
  • Organizer: 第32回滋賀医学総会
  • Place of Presentation: 滋賀
  • Year and Date: 2015-11-14
  • Invited
• [Presentation] 薬剤負荷による遺伝子型の予測が困難であった QT 延長症候群の一例 (2015)
  • Author(s): 中村恵理子、伊藤英樹、藤居祐介、加藤浩一、澤山裕一、八木典章、松本祐一、福山 恵、服部哲久、木村紘美、小澤友哉、芦原貴司、酒井 宏、山本 孝、林 秀樹、福原武久、堀江 稔
  • Organizer: 第119回日本循環器学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2015-06-20
• [Presentation] アミオダロンによる間質性肺炎が示唆され、異なる経過を辿った3症例についての検討 (2014)
  • Author(s): 肥後洋祐、小澤友哉、澤山裕一、冨田行則、八木典章、加藤浩一、福山 恵、服部哲久、松本祐一、木村紘美、酒井 宏、伊藤英樹、芦原貴司、山本 孝、林 秀樹、堀江 稔
  • Organizer: 第77回滋賀県循環器疾患研究会
  • Place of Presentation: 滋賀
  • Year and Date: 2014-12-06
• [Presentation] 産褥期に発症したAT3欠乏症による致死的肺塞栓症の一例 (2014)
  • Author(s): 田中智基、八木典章、酒井 宏、伊藤英樹、山本 孝、堀江 稔、江口 豊
  • Organizer: 第118回日本循環器学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-29
• [Presentation] 好酸球増多症に伴う心筋障害から右心不全を呈した1例 (2014)
  • Author(s): 澤山裕一、酒井 宏、八木典章、木村紘美、松本祐一、伊藤英樹、山本 孝、堀江 稔
  • Organizer: 第118回日本循環器学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-29
• [Presentation] 心肥大の進行が契機となり発見された心AL アミロイドーシスの1例 (2014)
  • Author(s): 八木典章、酒井 宏、冨田行則、伊藤英樹、山本 孝、堀江 稔
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] Ａ型大動脈解離術後遠隔期に心不全を発症し、診断に苦慮した一症例 (2014)
  • Author(s): 澤山裕一、木村紘美、西川絢子、冨田行則、八木典章、内貴乃生、松本祐一、酒井 宏、小澤友哉、伊藤英樹、山本 孝、堀江 稔、浅井 徹
  • Organizer: 第117回日本循環器学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-12
• [Presentation] 難治性心不全の診断にMDCTが有用であった一症例 (2014)
  • Author(s): 西川絢子、木村紘美、澤山裕一、児玉健二、冨田行則、八木典章、内貴乃生、松本祐一、酒井 宏、小澤友哉、伊藤英樹、山本 孝、堀江 稔、浅井 徹
  • Organizer: 第5回滋賀循環器画像研究会
  • Place of Presentation: 滋賀
  • Year and Date: 2014-06-21